Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6I5GR)

Drug Name
Promethazine Drug Info
Synonyms
Antiallersin; Aprobit; Avomine; Camergan; Dimapp; Diphergan; Diprazin; Diprazine; Diprozin; Fargan; Fenazil; Fenetazina; Fenetazine; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Metaryl; Pelpica; Phargan; Phenargan; Phenerzine; Phensedyl; Pilothia; Pilpophen; Pipolphene; Proazaimine; Proazamine; Procit; Promacot; Promazinamide; Promergan; Promesan; Prometasin; Prometazin; Prometazina; Prometazine; Prometh; Promethacon; Promethaine; Promethazin; PromethazineHcl; Promethazinum; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; Remsed; Romergan; Rumergan; Tanidil; Thiergan; Valergine; Vallergine; Lilly 01516; Lilly 1516; RP 3277; SKF 1498; WY 509; A-91033; Atosil (TN); Avomine (TN); Fargan (TN); Farganesse (TN); Lergigan (TN); Phenergan (TN); Phenoject-50; Pro-50; Prometazina [INN-Spanish]; Promethazine [INN:BAN]; Promethazinum [INN-Latin]; Promethegan (TN); Prothiazine (TN); Receptozine (TN); Romergan (TN); Zipan-25; Dimethylamino-isopropyl-phenthiazin; Dimethylamino-isopropyl-phenthiazin [German]; Promethazine (JAN/INN)
Indication
Disease Entry ICD 11 Status REF
Hyperemesis gravidarum Approved [1]
Nausea MD90 Approved [2]
Seasonal allergic rhinitis CA08.01 Approved [1]
Urticaria EB00-EB05 Approved [1]
Vasomotor/allergic rhinitis CA08 Approved [1]
Vomiting MD90 Approved [1]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [3]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [4]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
4927
ChEBI ID
CHEBI:8461
CAS Number
CAS 60-87-7
TTD Drug ID
DM6I5GR
VARIDT Drug ID
DR00674
INTEDE Drug ID
DR1353
ACDINA Drug ID
D00561

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HUMAN clathrin-mediated endocytosis (RME)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triflupromazine DMKFQJP Nausea MD90 Approved [3]
Thiethylperazine DMU3IET Nausea MD90 Approved [3]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [3]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [13]
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [14]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [15]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [16]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [17]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [5]
Doxepin DMPI98T Anxiety Approved [18]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [5]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [19]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [20]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [26]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [27]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [28]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [29]
Propranolol DM79NTF Angina pectoris BA40 Approved [30]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [33]
Estrone DM5T6US Acne vulgaris ED80 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [36]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [39]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [40]
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Drug(s) Affected By Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [41]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [42]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [43]
Rivastigmine DMG629M Alzheimer disease 8A20 Approved [44]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [45]
Succinylcholine DM2ET1M Plasma cell myeloma 2A83.1 Approved [46]
Ethopropazine DM0N3L7 Parkinson disease 8A00.0 Approved [42]
Dimenhydrinate DM264B3 Meniere disease AB31.0 Approved [9]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [47]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [9]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [48]
Diazepam DM08E9O Alcohol withdrawal Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [50]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [48]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [48]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [48]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [48]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [11]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [65]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [66]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [68]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [69]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [70]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [72]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [10]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [10]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [10]
Ethacrynic acid DM60QMR Edema MG29 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [10]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [83]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [89]
Ethacrynic acid DM60QMR Edema MG29 Approved [90]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
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Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [106]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [114]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [115]
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Drug(s) Affected By Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [12]
Testosterone DM7HUNW Hot flushes GA30 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [118]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [119]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [120]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [121]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [122]
Urethane DM7NSI0 N. A. N. A. Phase 4 [123]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [11]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [11]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [11]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [11]
Amikacin DM5PDRB Bacteremia 1A73 Approved [11]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [11]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [11]
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Drug(s) Affected By Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [125]
Arsenic DMTL2Y1 N. A. N. A. Approved [126]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [127]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [50]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [129]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [130]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [131]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [132]
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Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [134]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [135]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [5]
HUMAN clathrin-mediated endocytosis (RME) TTAIY2U . Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [6]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) OTY0YGT9 AMRA1_HUMAN Gene/Protein Processing [8]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Gene/Protein Processing [8]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [8]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [8]
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Gene/Protein Processing [9]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [10]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [8]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [11]
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) OT15YWU7 NR3L1_HUMAN Gene/Protein Processing [12]

References

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6 Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Letter
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