Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9S2JW)

Drug Name
Aldosterone Drug Info
Synonyms
ALDOSTERONE; 52-39-1; Electrocortin; Aldocortin; Aldocortene; Aldocorten; (+)-Aldosterone; Elektrocortin; d-Aldosterone; Reichstein X; 18-Oxocorticosterone; Aldosteronum; Aldosterona; Aldosteronum [INN-Latin]; Aldosterona [INN-Spanish]; [3H]aldosterone; 18-Aldocorticosterone; Aldosterone [INN:BAN:DCF]; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; NSC 73856; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; UNII-4964P6T9RB; Aldocorten; D-Aldosterone; Aldosterone, (11 beta,17 alpha)-Isomer; Aldosterone, (+-)-Isomer; (11BETA)-11,21-DIHYDROXY-3,20-DIOXOPREGN-4-EN-18-AL; (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 18,11-halbacetal; 11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al; 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5839
ChEBI ID
CHEMBL273453
CAS Number
CAS 52-39-1
TTD Drug ID
DM9S2JW
VARIDT Drug ID
DR00629
INTEDE Drug ID
DR0057

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Mineralocorticoid receptor (MR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [15]
Fludrocortisone DMUDIR8 Addison disease 5A74.0 Approved [16]
Desoxycorticosterone Acetate DMS0AFE Discovery agent N.A. Approved [15]
Desoxycorticosterone Pivalate DMSA4B3 Addison disease 5A74.0 Approved [17]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [18]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [15]
Finerenone DMM4FJ3 Chronic kidney disease GB61 Approved [19]
ZK-91587 DMJ94L0 Cardiovascular disease BA00-BE2Z Phase 2 [20]
Nerenone DMBJ3GL Diabetic nephropathy GB61.Z Phase 2 [21]
LY-2623091 DMFGNB4 Chronic kidney disease GB61 Phase 2 [22]
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Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [15]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [23]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [24]
Ethacrynic acid DM60QMR Edema MG29 Approved [25]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [26]
Bendroflumethiazide DM7EVLC High blood pressure BA00 Approved [27]
Trichlormethiazide DMHAQCO Hypertension BA00-BA04 Approved [28]
Hydroflumethiazide DMVPUQI Congestive heart failure BD10 Approved [27]
Methyclothiazide DMN7SDE Edema MG29 Approved [27]
Chlorthalidone DM4DMBT Edema MG29 Approved [29]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Folic Acid DMEMBJC Colorectal carcinoma Approved [33]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [44]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [47]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [51]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [49]
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Drug(s) Metabolized By Steroid 11-beta-hydroxylase (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [55]
deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [56]
Drug(s) Metabolized By Aldosterone synthase (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [55]
deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [57]
Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [61]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [45]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [66]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [67]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [68]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [69]
Cepharanthine DM9Y5JB N. A. N. A. Approved [70]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [71]
Clozapine DMFC71L Schizophrenia 6A20 Approved [72]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [73]
Trifluoperazine DMKBYWI Anxiety Approved [74]
Olanzapine DMPFN6Y Bipolar depression Approved [72]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [81]
Leflunomide DMR8ONJ Arthritis FA20 Approved [82]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [83]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [84]
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Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [91]
Testosterone DM7HUNW Hot flushes GA30 Approved [92]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Panobinostat DM58WKG Chronic graft versus host disease Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Testosterone enanthate DMB6871 N. A. N. A. Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [110]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [111]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [112]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [114]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [115]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [119]
Panobinostat DM58WKG Chronic graft versus host disease Approved [106]
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Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [123]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [124]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [125]
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Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [127]
Panobinostat DM58WKG Chronic graft versus host disease Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Leflunomide DMR8ONJ Arthritis FA20 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ethanol DMDRQZU Chronic pain MG30 Approved [130]
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Drug(s) Affected By Amiloride-sensitive sodium channel subunit beta (SCNN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Testosterone DM7HUNW Hot flushes GA30 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [133]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [134]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [136]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [137]
Milchsaure DM462BT Pruritus EC90 Investigative [138]
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Drug(s) Affected By Amiloride-sensitive sodium channel subunit gamma (SCNN1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Panobinostat DM58WKG Chronic graft versus host disease Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [133]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [134]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Arsenic DMTL2Y1 N. A. N. A. Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [136]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [142]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [146]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [147]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [149]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [150]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [149]
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Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [113]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [113]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [155]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [156]
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Drug(s) Affected By Transient receptor potential cation channel subfamily M member 4 (TRPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [158]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [159]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [132]
Leflunomide DMR8ONJ Arthritis FA20 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [110]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [162]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
Quercetin DM3NC4M Obesity 5B81 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [169]
Ethacrynic acid DM60QMR Edema MG29 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [172]
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Drug(s) Affected By G protein-activated inward rectifier potassium channel 4 (KCNJ5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [173]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [174]
Arsenic DMTL2Y1 N. A. N. A. Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [175]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [176]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [177]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [178]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [174]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [179]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [180]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [87]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [183]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [184]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [185]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [187]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [188]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [193]
Ethanol DMDRQZU Chronic pain MG30 Approved [194]
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Drug(s) Affected By Pro-opiomelanocortin (POMC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [195]
Prednisone DM2HG4X Acute asthma CA23 Approved [196]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [197]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [198]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [199]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [200]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [201]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [202]
Ethanol DMDRQZU Chronic pain MG30 Approved [203]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [204]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mineralocorticoid receptor (MR) TT26PHO MCR_HUMAN Agonist [2]
Solute carrier family 12 member 1 (SLC12A1) TTS087L S12A1_HUMAN Blocker [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [6]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [7]
Steroid 11-beta-hydroxylase (CYP11B1) DEPE0RD C11B1_HUMAN Substrate [8]
Aldosterone synthase (CYP11B2) DE6TYUK C11B2_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [10]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Gene/Protein Processing [11]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Gene/Protein Processing [11]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G) OTSJYQVQ SCNNG_HUMAN Gene/Protein Processing [11]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [12]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [10]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Gene/Protein Processing [13]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Gene/Protein Processing [13]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Gene/Protein Processing [13]
G protein-activated inward rectifier potassium channel 4 (KCNJ5) OTA2MBIE KCNJ5_HUMAN Regulation of Drug Effects [14]

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