Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDBWHY)

Drug Name
Heroin diacetylmorphine Drug Info
Synonyms Diamorphine (TN)
Indication
Disease Entry ICD 11 Status REF
Neurological disorder 6B60 Approved [1]
Cross-matching ID
PubChem CID
5462328
ChEBI ID
CHEMBL27808
CAS Number
CAS 561-27-3
TTD Drug ID
DMDBWHY
INTEDE Drug ID
DR0807

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [6]
Drug(s) Affected By Integrin beta-1-binding protein 1 (ITGB1BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [9]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [10]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [13]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [14]
Paclitaxel DMLB81S Breast carcinoma Approved [14]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [15]
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Drug(s) Affected By Septin-4 (SEPTIN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [19]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [25]
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Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Testosterone enanthate DMB6871 N. A. N. A. Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Ethanol DMDRQZU Chronic pain MG30 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
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Drug(s) Affected By Synaptogyrin-3 (SYNGR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
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Drug(s) Affected By Deformed epidermal autoregulatory factor 1 homolog (DEAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Bortezomib DMNO38U Leukemia Approved [40]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [41]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [42]
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Drug(s) Affected By Proenkephalin-B (PDYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ethanol DMDRQZU Chronic pain MG30 Approved [44]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [45]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [55]
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Drug(s) Affected By D(2) dopamine receptor (DRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Droperidol DM0DXA8 Nausea MD90 Approved [56]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [56]
Zuclopenthixol DMKYD5N Schizophrenia 6A20 Approved [56]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [57]
Sulpiride DMF54ZG Schizophrenia 6A20 Approved [58]
Risperidone DMN6DXL Bipolar I disorder Approved [59]
Olanzapine DMPFN6Y Bipolar depression Approved [60]
Methamphetamine DMPM4SK Anxiety Approved [61]
Bromocriptine DMVE3TK Acromegaly 5A60.0 Approved [62]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [63]
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Drug(s) Affected By Synaptotagmin-1 (SYT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [66]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Epinephrine DM3KJBC Acute asthma CA23 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Fructose DM43AN2 Vomiting MD90 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [77]
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Drug(s) Affected By Alpha-actinin-2 (ACTN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [81]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [41]
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Drug(s) Affected By Amphiphysin (AMPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Ethanol DMDRQZU Chronic pain MG30 Approved [86]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [87]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
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Drug(s) Affected By Syntaxin-binding protein 1 (STXBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [25]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [41]
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Drug(s) Affected By Myomegalin (PDE4DIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Panobinostat DM58WKG Chronic graft versus host disease Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Testosterone enanthate DMB6871 N. A. N. A. Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [94]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [3]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [95]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
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Drug(s) Affected By Adropin (ENHO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [3]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [97]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [98]
ORG2058 DMH1M6N Discovery agent N.A. Investigative [99]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [100]
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Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [103]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [82]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [104]
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Drug(s) Affected By Protein Churchill (CHURC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Urethane DM7NSI0 N. A. N. A. Phase 4 [105]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [41]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [106]
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Drug(s) Affected By Protein TMEPAI (PMEPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [109]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [109]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [87]
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Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [112]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [113]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [114]
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Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Selenium DM25CGV N. A. N. A. Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [115]
Bortezomib DMNO38U Leukemia Approved [40]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [116]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
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Drug(s) Affected By Mitoferrin-1 (SLC25A37)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [118]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [119]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [120]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [43]
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Drug(s) Affected By Protein FAM153A (FAM153A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [45]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [3]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [121]
Urethane DM7NSI0 N. A. N. A. Phase 4 [105]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [122]
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Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [13]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [123]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [38]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [124]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [125]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [127]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Testosterone enanthate DMB6871 N. A. N. A. Approved [27]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [129]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Acetylcholinesterase (ACHE) Main DME DEQ2BAJ ACES_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) OTEZVTI1 DNPH1_HUMAN Gene/Protein Processing [3]
Adropin (ENHO) OT91QASK ENHO_HUMAN Gene/Protein Processing [3]
Alpha-actinin-2 (ACTN2) OT9FOLD7 ACTN2_HUMAN Gene/Protein Processing [3]
Amphiphysin (AMPH) OTWPGWZX AMPH_HUMAN Gene/Protein Processing [3]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [3]
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) OT96NE03 BL1S6_HUMAN Gene/Protein Processing [3]
Ceramide glucosyltransferase OTRT5P5I CEGT_HUMAN Gene/Protein Processing [3]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Biotransformations [4]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Gene/Protein Processing [5]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Gene/Protein Processing [3]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine. Chem Biol Interact. 2018 Sep 25;293:107-114.
3 Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
4 Contribution of human esterases to the metabolism of selected drugs of abuse. Toxicol Lett. 2015 Jan 5;232(1):159-66. doi: 10.1016/j.toxlet.2014.10.026. Epub 2014 Oct 24.
5 Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Mol Psychiatry. 2000 Nov;5(6):664-72. doi: 10.1038/sj.mp.4000760.
6 How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
8 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
9 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
10 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
11 Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
12 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
13 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
14 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
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