Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDN12L)

• Drug Name: 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Drug Info
• Synonyms: Anthra[1,9-cd]pyrazol-6(2H)-one; 129-56-6; 1,9-Pyrazoloanthrone; SP600125; Pyrazolanthrone; Dibenzo[cd,g]indazol-6(2H)-one; Pyrazoleanthrone; SP 600125; Anthra-1,9-pyrazol-6-none; SP-600125; CI 70300; 2H-Dibenzo[cd,g]indazol-6-one; JNK Inhibitor II; SAPK Inhibitor II; NSC 75890; UNII-1TW30Y2766; ANTHRA(1,9-cd)PYRAZOL-6(2H)-ONE; EINECS 204-955-6; 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE; BRN 0746890; CHEMBL7064; MLS002693964; CHEBI:90695; ACPOUJIDANTYHO-UHFFFAOYSA-N; 1TW30Y2766

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 8515
  ChEBI ID: CHEBI:90695
  CAS Number: CAS 129-56-6
  TTD Drug ID: DMDN12L

Molecule-Related Drug Atlas

Drug(s) Targeting Stress-activated protein kinase JNK3 (JNK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[11]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[11]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[11]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[11]

Drug(s) Targeting Stress-activated protein kinase JNK1 (JNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NKP-1339	DM5AWK1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[11]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[11]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[11]

Drug(s) Targeting Stress-activated protein kinase JNK2 (JNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[11]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[11]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[11]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[11]

Drug(s) Targeting Dual specificity protein kinase TTK (MPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BOS172722	DMU790L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
BAY1161909	DMUK6YM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]
CFI-402257	DMH701Q	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
Tricyclic isoxazoloquinazoline derivative 2	DMH4TY1	N. A.	N. A.	Patented	[16]
Tricyclic isoxazoloquinazoline derivative 4	DM8VIM4	N. A.	N. A.	Patented	[16]
Tricyclic isoxazoloquinazoline derivative 3	DML2PWF	N. A.	N. A.	Patented	[16]
GNE-7915	DMYWM56	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Jun N terminal kinase (JNK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AM-111	DM4E9PK	Neurological disorder	6B60	Phase 3	[18]
BGP-15	DMYDM68	Type-2 diabetes	5A11	Phase 2	[19]
CC-401	DMPMO6G	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]
CC-930	DMHVEGJ	Discoid lupus erythematosus	EB51.0	Phase 2	[21]
PMID25991433-Compound-Q1	DMEMSB2	N. A.	N. A.	Patented	[11]
PMID25991433-Compound-O1	DMH073T	N. A.	N. A.	Patented	[11]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[22]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[27]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[28]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[28]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[29]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[30]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[31]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[37]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[38]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[39]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[40]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[40]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[40]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[41]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[42]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[43]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[44]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[45]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[46]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[47]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[50]
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[57]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[64]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[68]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[69]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[70]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[82]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[89]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[90]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[98]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[105]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[106]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[113]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[105]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[118]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[116]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[121]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[122]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[126]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[131]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[135]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[142]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[143]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[144]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[163]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[64]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[171]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[61]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[176]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[183]
Fructose	DM43AN2	Vomiting	MD90	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[188]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[189]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[190]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[191]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[194]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[89]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[195]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[197]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[200]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[208]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[219]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[221]

Drug(s) Affected By Casein kinase I isoform delta (CSNK1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[225]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[228]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[208]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[162]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[233]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[235]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[236]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[200]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[237]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[231]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[238]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[240]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[241]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[242]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[243]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[244]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Selenium	DM25CGV	N. A.	N. A.	Approved	[245]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[250]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[251]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[262]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[228]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[265]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[106]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[270]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]

Drug(s) Affected By Cytochrome P450 4F11 (CYP4F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[273]

Drug(s) Affected By C-type lectin domain family 4 member K (CD207)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[276]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dual specificity protein kinase TTK (MPS1)	TTP7EGM	TTK_HUMAN	Inhibitor	[1]
Jun N terminal kinase (JNK)	TTR2TXZ	MK08_HUMAN; MK09_HUMAN; MK10_HUMAN	Inhibitor	[2]
Stress-activated protein kinase JNK1 (JNK1)	TT0K6EO	MK08_HUMAN	Inhibitor	[1]
Stress-activated protein kinase JNK2 (JNK2)	TTHS0U8	MK09_HUMAN	Inhibitor	[3]
Stress-activated protein kinase JNK3 (JNK3)	TT056SO	MK10_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
C-type lectin domain family 4 member K (CD207)	OTI9RUDN	CLC4K_HUMAN	Gene/Protein Processing	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[5]
Casein kinase I isoform delta (CSNK1D)	OTNF4S77	KC1D_HUMAN	Gene/Protein Processing	[6]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[8]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[4]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[9]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Post-Translational Modifications	[10]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Gene/Protein Processing	[6]

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