Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHO29Y)

• Drug Name: T83193 Drug Info
• Synonyms: vanillin; 4-Hydroxy-3-methoxybenzaldehyde; 121-33-5; Vanillaldehyde; Vanillic aldehyde; Vanilla; p-Vanillin; 2-Methoxy-4-formylphenol; Vanilline; Lioxin; 4-Hydroxy-m-anisaldehyde; 3-Methoxy-4-hydroxybenzaldehyde; Zimco; Benzaldehyde, 4-hydroxy-3-methoxy-; 4-Hydroxy-3-methoxy-benzaldehyde; Vanilin; p-Hydroxy-m-methoxybenzaldehyde; 4-Formyl-2-methoxyphenol; Methylprotocatechuic aldehyde; Vanillin (natural); 4-Hydroxy-5-methoxybenzaldehyde; m-Anisaldehyde, 4-hydroxy-; Protocatechualdehyde, methyl-; Vanillin [USAN]; Vanillin (NF)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1183
  ChEBI ID: CHEBI:18346
  CAS Number: CAS 121-33-5
  TTD Drug ID: DMHO29Y

Molecule-Related Drug Atlas

Drug(s) Targeting Succinate-semialdehyde dehydrogenase (ALDH5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlormerodrin	DMSF4PR	Diagnostic imaging	N.A.	Approved	[8]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[9]
1-(4-hydroxyphenyl)prop-2-en-1-one	DM145QS	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[10]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[10]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[10]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[11]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[10]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[12]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[13]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[12]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[14]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[16]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[17]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[18]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[19]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[20]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[21]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[22]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[23]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[24]
Budipine	DMODHQI	Migraine	8A80	Approved	[25]

Drug(s) Affected By Carbonic anhydrase 1 (CA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[26]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[27]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[5]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[29]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[27]
Indomethacin	DMSC4A7	Bursitis		Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[32]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[5]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[30]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[36]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[37]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[50]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[51]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[52]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[53]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[58]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[59]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[60]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[61]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[63]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[68]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[66]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[69]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[69]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[50]

Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[93]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Fructose	DM43AN2	Vomiting	MD90	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[107]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[108]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]

Drug(s) Affected By Glycogen phosphorylase, liver form (PYGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[115]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[125]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[63]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[130]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[131]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[140]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[144]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[146]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[147]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[47]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[153]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[157]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[163]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[167]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[76]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[170]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[178]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[47]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[188]

Drug(s) Affected By Dual specificity protein kinase CLK2 (CLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[173]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[191]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[192]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[115]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]

Drug(s) Affected By Nucleotide sugar transporter SLC35D2 (SLC35D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[205]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[206]

Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[210]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[211]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[222]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[223]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[66]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[163]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[225]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[2]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[3]
Succinate-semialdehyde dehydrogenase (ALDH5A1)	TTJUWVB	SSDH_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[4]
Carbonic anhydrase 1 (CA1)	OTNFBVVQ	CAH1_HUMAN	Gene/Protein Processing	[5]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Gene/Protein Processing	[5]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Gene/Protein Processing	[6]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[6]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Gene/Protein Processing	[7]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Gene/Protein Processing	[6]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Gene/Protein Processing	[6]

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