Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLPAOB)

Drug Name
Allopurinol Drug Info
Synonyms
Adenock; Ailural; Ailurial; Allohexal; Allohexan; Alloprin; Allopur; Allopurin; Allopurinolum; Allorin; Allozym; Allpargin; Allural; Aloprim; Alopurinol; Aloral; Alositol; Aluline; Anoprolin; Anzief; Apulonga; Apurin; Apurol; Atisuril; Bleminol; Bloxanth; Caplenal; Capurate; Cellidrin; Cosuric; Dabrosin; Dabroson; Embarin; Epidropal; Epuric; Foligan; Geapur; Gichtex; Gotax; Hamarin; Hexanuret; Jenapurinol; Ketanrift; Ledopur; Lopurin; Lysuron; Milurit; Milurite; Miniplanor; Monarch; Nektrohan; Novopurol; Progout; Pureduct; Purinol; Remid; Riball; Rimapurinol; Roucol; Sigapurol; Suspendol; Takanarumin; Tipuric; Urbol; Uribenz; Uricemil; Uridocid; Uriprim; Uripurinol; Uritas; Urobenyl; Urolit; Urosin; Urtias; Xanthomax; Xanturat; Xanturic; Zygout; Zyloprim; Zyloric; Dura Al; Pan Quimica; A 8003; BW 56158; Urtias 100; AL-100; Allo-Puren; Allohexal (TN); Allopurinol(I); Allosig (TN); Apo-Allopurinol; BW 56-158; Ketobun-A; Progout (TN); Puricos (TN); Quimica, Pan; Zyloprim (TN); Zyloric (TN); BW-56-158; B. W. 56-158; 4-HPP
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Approved [1]
Hyperuricaemia 5C55.Y Approved [2]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Therapeutic Class
Antimetabolites
Cross-matching ID
PubChem CID
135401907
ChEBI ID
CHEMBL1467
CAS Number
CAS 315-30-0
TTD Drug ID
DMLPAOB
VARIDT Drug ID
DR00074
INTEDE Drug ID
DR0066
ACDINA Drug ID
D00020

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [14]
Fosdenopterin DMR0TYK Molybdenum cofactor deficiency 5B5K.A Approved [15]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [16]
Oxypurinol DMURH4X Heart failure BD10-BD13 Phase 2/3 [17]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [18]
Topiroxostat DMA04DE Gout FA25 Phase 2 [19]
TMX-049 DME8PFQ Diabetic nephropathy GB61.Z Phase 2 [20]
LC-350189 DMHT3CB Gout FA25 Phase 1 [21]
Azaindole derivative 5 DMD2BL3 N. A. N. A. Patented [22]
Fused heterocyclic compound 3 DM2QVHY N. A. N. A. Patented [22]
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Drug(s) Transported By Organic anion transporter 2 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [27]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [28]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [29]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [30]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [31]
Theophylline DMRJFN9 Bronchitis CA20 Approved [27]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [33]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [34]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [35]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [36]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [37]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [38]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [39]
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Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [41]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [42]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [43]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [44]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [45]
Mesalazine DMOL5IU Diverticulitis Approved [46]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [47]
Clonazepam DMTO13J Absence epilepsy Approved [48]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [49]
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Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [24]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [24]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [24]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [30]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [50]
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Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [53]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [63]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [64]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [66]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [64]
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Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [72]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [73]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [68]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
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Drug(s) Affected By Protein disulfide-isomerase (P4HB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [8]
Etretinate DM2CZFA Keratosis ED56 Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [86]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [89]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [94]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [92]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [99]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [100]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [72]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [107]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [110]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [111]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [114]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [117]
Gefitinib DM15F0X Colon adenocarcinoma Approved [118]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [121]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [112]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [122]
Paclitaxel DMLB81S Breast carcinoma Approved [123]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [111]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [10]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [114]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [127]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [68]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [128]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [130]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [134]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [137]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [138]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [139]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [139]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [140]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [139]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [139]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [139]
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Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [142]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [143]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [144]
Ciprofibrate DMGC5DB Hyperlipoproteinemia 5C80 Approved [145]
Capsaicin DMGMF6V Back pain ME84.Z Approved [146]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [147]
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Drug(s) Affected By Glycophorin-A (GYPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [149]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [150]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [151]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [152]
Arsenic DMTL2Y1 N. A. N. A. Approved [153]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [154]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [155]
APIGENIN DMI3491 Discovery agent N.A. Investigative [156]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [157]
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Drug(s) Affected By HLA class I histocompatibility antigen protein P5 (HCP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [158]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [159]
Pazopanib DMF57DM N. A. N. A. Approved [160]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [4]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
RNA cytidine acetyltransferase (hALP) Main DME DEZV4AP NAT10_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Gene/Protein Processing [8]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Gene/Protein Processing [9]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [8]
Glycophorin-A (GYPA) OTABU4YV GLPA_HUMAN Drug Response [10]
HLA class I histocompatibility antigen protein P5 (HCP5) OTV0YRI8 HCP5_HUMAN Drug Response [11]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Drug Response [12]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Drug Response [12]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [13]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Gene/Protein Processing [8]

References

1 Allopurinol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6795).
3 Allopurinol: xanthine oxidase inhibitor. Tex Med. 1966 Jan;62(1):100-1.
4 Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14.
5 Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83.
6 Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol. 1999 Jan;54(11):869-76.
7 Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells. J Appl Toxicol. 2016 Sep;36(9):1120-8. doi: 10.1002/jat.3272. Epub 2015 Dec 7.
8 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
9 Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid. Toxicol Sci. 2021 May 27;181(2):295-305. doi: 10.1093/toxsci/kfab034.
10 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
11 Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. Clin Pharmacol Ther. 2013 Feb;93(2):153-8. doi: 10.1038/clpt.2012.209. Epub 2012 Oct 17.
12 A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. Int J Immunogenet. 2011 Aug;38(4):303-9. doi: 10.1111/j.1744-313X.2011.01011.x. Epub 2011 May 4.
13 Systemic drugs inducing non-immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells. J Appl Toxicol. 2015 Apr;35(4):398-406. doi: 10.1002/jat.3033. Epub 2014 Aug 4.
14 Clinical pipeline report, company report or official report of Takeda (2009).
15 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
16 Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. J Nat Prod. 2009 Apr;72(4):725-31.
17 Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52.
18 Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8.
19 QT/QTc study conducted in Japanese adult healthy subjects: a novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation. J Clin Pharmacol. 2014 Apr;54(4):446-52.
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