Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUI0CH)

Drug Name
Tobramycin Drug Info
Synonyms
Aktob; Brulamycin; Distobram; Gotabiotic; NEBRAMYCIN; Nebcin; Nebicin; Obracin; Obramycin; Sybryx; TOY; Tenebrimycin;Tenemycin; Tobacin; Tobi; Tobracin; Tobradex; Tobradistin; Tobralex; Tobramaxin; Tobramicin; Tobramicina; Tobramitsetin; Tobramycetin; Tobramycine; Tobramycinum; Tobrased; Tobrasone; Tobrex; Deoxykanamycin B; Nebramycin VI; TOBRAMYCIN SULFATE; Tobramycin for Inhalation; Tobramycin solution for inhalation; A 12253A; Lilly 47663; NF 6; Nebramycin 6; Nebramycin factir 6; Nebramycin factor 6; Nebcin (Sulfate); SPRC-AB01; TobraDex (TN); Tobracin (TN); Tobramicina [INN-Spanish]; Tobramycin, Free Base; Tobramycine [INN-French]; Tobramycinum [INN-Latin]; Tobrex (TN); Tobramycin (JP15/USP); Tobramycin[USAN:BAN:INN:JAN]; TOA-(1-6)2TB-(4-1)TOC; TOA-(1-6)TOB-(4-1)TOC; 1-Epitobramycin; 3'-Deoxykanamycin B
Indication
Disease Entry ICD 11 Status REF
Bacteremia 1A73 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Blepharoconjunctivitis Approved [1]
Corneal abrasion NA06.4 Approved [1]
Dacryocystitis Approved [1]
Demodex blepharitis 1G07 Approved [1]
Neonatal sepsis Approved [1]
Peritonitis Approved [1]
Rosacea ED90.0 Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
36294
ChEBI ID
CHEBI:28864
CAS Number
CAS 32986-56-4
TTD Drug ID
DMUI0CH
INTEDE Drug ID
DR1606

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [11]
Gentamicin DMKINJO Bacteremia 1A73 Approved [12]
TP-434 DM5A31S Intra-abdominal infection 1A40 Approved [13]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [12]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [14]
Sarecycline DMLZNIQ Acne vulgaris ED80 Approved [15]
ME1100 DM39PSZ Bacterial pneumonia CA40.0 Phase 1 [16]
TP-6076 DM5RIT8 Enterobacteriaceae infection MG50.C Phase 1 [17]
TP-271 DM3PJSE Pneumonia CA40 Phase 1 [18]
TP 6076 DMD0NA1 Multidrug resistant infection MG51 Phase 1 [17]
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Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [19]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [20]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [21]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [22]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [23]
Mesalazine DMOL5IU Diverticulitis Approved [24]
Allopurinol DMLPAOB Gout FA25 Approved [25]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [26]
Clonazepam DMTO13J Absence epilepsy Approved [27]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [28]
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Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [6]
Framycetin DMF8DNE Acute liver failure DB91 Approved [6]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [6]
Amikacin DM5PDRB Bacteremia 1A73 Approved [6]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [6]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [6]
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Drug(s) Metabolized By Aminoglycoside phosphotransferase (aph-Ib)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [5]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [5]
Sisomicin DM92P0F N. A. N. A. Approved [29]
Dibekacin DMTX0PZ N. A. N. A. Phase 4 [29]
Drug(s) Metabolized By Kanamycin/gentamycin-resistance enzyme (aacA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [5]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [5]
Drug(s) Metabolized By Aminoglycoside N-acetyltransferase (aacC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Framycetin DMF8DNE Acute liver failure DB91 Approved [6]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [6]
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
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Drug(s) Affected By Beta-2-microglobulin (B2M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Pamidronate DMB4AVP Bone Paget disease Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Folic Acid DMEMBJC Colorectal carcinoma Approved [58]
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Drug(s) Affected By Survival motor neuron protein (SMN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amikacin DM5PDRB Bacteremia 1A73 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [60]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Arsenic DMTL2Y1 N. A. N. A. Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [64]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [65]
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Drug(s) Affected By Phospholipase A2 (PLA2G1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [67]
Amikacin DM5PDRB Bacteremia 1A73 Approved [7]
Gentamicin DMKINJO Bacteremia 1A73 Approved [7]
Dibekacin DMTX0PZ N. A. N. A. Phase 4 [7]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [68]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [69]
Rutin DMEHRAJ Discovery agent N.A. Investigative [70]
EGTA DMW9MRO Discovery agent N.A. Investigative [71]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [74]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [75]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [76]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [60]
Methamphetamine DMPM4SK Anxiety Approved [77]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [78]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [79]
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Drug(s) Affected By Lysozyme C (LYZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [86]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [87]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [92]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA) TTOVFH2 NOUNIPROTAC Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Substrate [4]
Aminoglycoside phosphotransferase (aph-Ib) DE5WGIM A0A075C7U3_CAMJU Substrate [5]
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Substrate [6]
Aminoglycoside N-acetyltransferase (aacC2) DEJADS9 AAC6_ACIBA Substrate [6]
Kanamycin/gentamycin-resistance enzyme (aacA) DECXWN8 J3S7E2_CAMCO Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Drug Response [7]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Gene/Protein Processing [8]
Beta-hexosaminidase (nag1) OTQCIZOD P87258_TRIHA Drug Response [7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Gene/Protein Processing [9]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [9]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Drug Response [7]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Drug Response [7]
mRNA decay activator protein ZFP36 OTJYLJ02 TTP_HUMAN Gene/Protein Processing [9]
Phospholipase A2 (PLA2G1B) OT1GG9FK PA21B_HUMAN Drug Response [7]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Gene/Protein Processing [10]

References

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57 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
58 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
59 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
60 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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64 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
65 Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum Genet. 2008 Jan;122(6):635-43. doi: 10.1007/s00439-007-0441-0. Epub 2007 Oct 26.
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67 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
68 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
69 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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