Details of Disease

General Information of Disease (ID: DISG6BLX)

• Disease Name: Adult acute monocytic leukemia
• Synonyms: acute monocytic leukemia; acute monocytic leukaemia; adult acute monocytic leukemia; adult acute differentiated monocytic leukemia (M5b); adult acute differentiated monocytic leukaemia (M5b); acute monocytic leukemia of adults; acute monocytic leukaemia of adults; M5b adult acute leukemia; M5b adult acute leukaemia; M5b adult acute differentiated monocytic leukemia; M5b adult acute differentiated monocytic leukaemia
• Definition: A acute monocytic leukemia that occurs in an adult.
• Disease Hierarchy:
  DIS28NEL: Acute monocytic leukemia
  DISG6BLX: Adult acute monocytic leukemia
• Disease Identifiers:
  MONDO ID: MONDO_0000875
  UMLS CUI: C0280634
  MedGen ID: 128856

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 10 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bevacizumab	DMSD1UN	Approved	Monoclonal antibody	[1]
Cholecalciferol	DMGU74E	Approved	Small molecular drug	[2]
Cytarabine	DMZD5QR	Approved	Small molecular drug	[3]
Decitabine	DMQL8XJ	Approved	Small molecular drug	[4]
Etoposide	DMNH3PG	Approved	Small molecular drug	[5]
Idarubicin	DMM0XGL	Approved	Small molecular drug	[6]
Mitoxantrone	DMM39BF	Approved	Small molecular drug	[7]
Omacetaxine mepesuccinate	DMPU2WX	Approved	Small molecular drug	[8]
Pravastatin	DM6A0X7	Approved	Small molecular drug	[9]
Vorinostat	DMWMPD4	Approved	Small molecular drug	[10]

This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cyclosporin A	DMUYKBZ	Phase 2 Trial	Small molecular drug	[11]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FLT3	TTGJCWZ	Strong	Genetic Variation	[12]
KAT6A	TT6O1J0	Strong	Genetic Variation	[13]
KMT2A	TT1GNDM	Strong	Biomarker	[14]
SEPTIN6	TTAGE7U	Strong	Altered Expression	[15]
SIRPA	TTBRJS9	Strong	Altered Expression	[16]
SYVN1	TT8XKYM	Strong	Biomarker	[17]

This Disease Is Related to 14 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABI1	OT5H4M62	Strong	Genetic Variation	[18]
AMFR	OTQRX7LC	Strong	Biomarker	[19]
ARHGAP26	OTNGQU7A	Strong	Genetic Variation	[20]
CAB39L	OTQEBL0W	Strong	Genetic Variation	[21]
CIRBP	OTXWTPBL	Strong	Altered Expression	[22]
DERL3	OTRZRT6Q	Strong	Biomarker	[17]
ELL	OTCBN5LF	Strong	Genetic Variation	[23]
FANCB	OTMZTXB5	Strong	Genetic Variation	[24]
JARID2	OT14UM8H	Strong	Biomarker	[25]
MLLT3	OTXH4DDG	Strong	Genetic Variation	[26]
MLLT6	OTOC9OGX	Strong	Genetic Variation	[27]
MYO1F	OTOAV4AR	Strong	Biomarker	[28]
NONO	OTN36Q6U	Strong	Biomarker	[29]
PHF6	OT8DXI40	Strong	Genetic Variation	[30]

References

• [1] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [2] Cholecalciferol FDA Label
• [3] Cytarabine FDA Label
• [4] Decitabine FDA Label
• [5] Etoposide FDA Label
• [6] Idarubicin FDA Label
• [7] Mitoxantrone FDA Label
• [8] Omacetaxine mepesuccinate FDA Label
• [9] Pravastatin FDA Label
• [10] Vorinostat FDA Label
• [11] Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia. Haematologica. 2023 Jan 1;108(1):61-68.
• [12] Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.BMC Cancer. 2018 May 29;18(1):604. doi: 10.1186/s12885-018-4534-z.
• [13] Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation.Leukemia. 2001 Jan;15(1):89-94. doi: 10.1038/sj.leu.2401983.
• [14] Ets1 Plays a Critical Role in MLL/EB1-Mediated Leukemic Transformation in a Mouse Bone Marrow Transplantation Model.Neoplasia. 2019 May;21(5):469-481. doi: 10.1016/j.neo.2019.03.006. Epub 2019 Apr 8.
• [15] MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature.Genes Chromosomes Cancer. 2003 Sep;38(1):8-12. doi: 10.1002/gcc.10235.
• [16] Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP- in peritoneal macrophages.J Obstet Gynaecol Res. 2019 May;45(5):1045-1057. doi: 10.1111/jog.13938. Epub 2019 Mar 6.
• [17] A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia.Cancer Genet Cytogenet. 2010 Jun;199(2):134-8. doi: 10.1016/j.cancergencyto.2010.02.006.
• [18] Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?.Cancer Genet Cytogenet. 2002 Nov;139(1):57-9. doi: 10.1016/s0165-4608(02)00616-7.
• [19] Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells.Int J Mol Med. 2015 Sep;36(3):627-32. doi: 10.3892/ijmm.2015.2267. Epub 2015 Jun 30.
• [20] MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23).Genes Chromosomes Cancer. 2004 Dec;41(4):400-4. doi: 10.1002/gcc.20097.
• [21] Leukemia-associated gene MLAA-34 reduces arsenic trioxide-induced apoptosis in HeLa cells via activation of the Wnt/-catenin signaling pathway.PLoS One. 2017 Oct 23;12(10):e0186868. doi: 10.1371/journal.pone.0186868. eCollection 2017.
• [22] Effect of moderate hypothermia on gene expression by THP-1 cells: a DNA microarray study.Physiol Genomics. 2006 Jun 16;26(1):91-8. doi: 10.1152/physiolgenomics.00296.2005. Epub 2006 Apr 4.
• [23] Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero.Pediatr Blood Cancer. 2009 Aug;53(2):220-2. doi: 10.1002/pbc.22040.
• [24] Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b).Int J Hematol. 2001 Jul;74(1):53-7. doi: 10.1007/BF02982549.
• [25] JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.Int J Hematol. 2015 Jul;102(1):76-85. doi: 10.1007/s12185-015-1797-x. Epub 2015 May 5.
• [26] MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.Oncogene. 1993 Nov;8(11):3085-92.
• [27] Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21).Int J Hematol. 2005 Jul;82(1):38-41. doi: 10.1532/IJH97.05025.
• [28] The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.Oncogene. 2005 Aug 4;24(33):5191-7. doi: 10.1038/sj.onc.1208711.
• [29] Knockdown of p54nrb inhibits migration, invasion and TNF- release of human acute monocytic leukemia THP1 cells.Oncol Rep. 2016 Jun;35(6):3742-8. doi: 10.3892/or.2016.4756. Epub 2016 Apr 20.
• [30] Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma.Acta Oncol. 2012 Jan;51(1):107-11. doi: 10.3109/0284186X.2011.592148. Epub 2011 Jul 8.