Details of Disease

General Information of Disease (ID: DISHSTQ0)

Disease Name	Vasomotor/allergic rhinitis
Disease Class	CA08: Vasomotor/allergic rhinitis
Definition	Inflammation in the nasal cavity mucosa that results from the abnormal regulation of the blood flow in the nose. It may be caused by temperature fluctuations, air pollution, strong odors, and tobacco smoke. It results in chronic nasal congestion, sneezing, and running nose.
Disease Hierarchy	DISKLMN7: Rhinitis DIS3U9HN: Allergic rhinitis DISHSTQ0: Vasomotor/allergic rhinitis
ICD Code	ICD-11 ICD-11: CA08 ICD-10 ICD-10: J30-J39, J30
Disease Identifiers	MONDO ID MONDO_0006004 MESH ID D012223 UMLS CUI C0035460 MedGen ID 11229 SNOMED CT ID 8229003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 30 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acrivastine	DMTIGA0	Approved	Small molecular drug	[1]
Antazoline	DMA04JS	Approved	Small molecular drug	[2]
Azatadine	DMZ80SB	Approved	Small molecular drug	[3]
Azelastine	DMXTMBJ	Approved	Small molecular drug	[4]
Brompheniramine	DMFOVSD	Approved	Small molecular drug	[5]
Carbinoxamine	DMCT31R	Approved	Small molecular drug	[6]
Cetirizine	DMOMP9U	Approved	Small molecular drug	[7]
Chlophedianol	DMXGJEI	Approved	Small molecular drug	[8]
Clemastine	DMBZWQL	Approved	Small molecular drug	[9]
Cyclizine	DM9G7BS	Approved	Small molecular drug	[10]
Desloratadine	DM56YN7	Approved	Small molecular drug	[11]
Dexbrompheniramine	DMKVWGE	Approved	Small molecular drug	[12]
Dexchlorpheniramine Maleate	DMA8DPN	Approved	Small molecular drug	[13]
Dextromethorphan	DMUDJZM	Approved	Small molecular drug	[14]
Diphenhydramine	DMKQTBA	Approved	Small molecular drug	[15]
Diphenylpyraline	DMW4X37	Approved	Small molecular drug	[16]
Doxylamine	DMKOXFE	Approved	Small molecular drug	[17]
Ephedrine	DMMV0KW	Approved	Small molecular drug	[18]
Loratadine	DMF3AN7	Approved	Small molecular drug	[19]
Mepyramine	DMB4SFH	Approved	Small molecular drug	[20]
Phenindamine	DMDTC7R	Approved	Small molecular drug	[20]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[21]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[22]
Promethazine	DM6I5GR	Approved	Small molecular drug	[23]
Pseudoephedrine	DMIVJ0D	Approved	Small molecular drug	[18]
Scopolamine	DMOM8AL	Approved	Small molecular drug	[24]
Tripelennamine	DMZBU15	Approved	Small molecular drug	[25]
Triprolidine	DM7SWIA	Approved	Small molecular drug	[18]
Beclomethasone dipropionate	DM5NW1E	Phase 4	NA	[26]
Chlorphenamine	DM6C4YJ	Phase 4	NA	[20]
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⏷ Show the Full List of 30 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chlorcyclizine	DM3L52Q	Phase 1	Small molecular drug	[27]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Phenylpropanolamine	DMTFK3O	Withdrawn from market	Small molecular drug	[28]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MUC7	OTSTMP0X	Strong	Altered Expression	[29]
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References

1	Acrivastine FDA Label
2	Antazoline FDA Label
3	Azatadine FDA Label
4	Azelastine FDA Label
5	Brompheniramine FDA Label
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7	Cetirizine FDA Label
8	Chlophedianol FDA Label
9	Clemastine FDA Label
10	Cyclizine FDA Label
11	Desloratadine FDA Label
12	Dexbrompheniramine FDA Label
13	Dexchlorpheniramine maleate FDA Label
14	Dextromethorphan FDA Label
15	Diphenhydramine FDA Label
16	Diphenylpyraline FDA Label
17	Doxylamine FDA Label
18	Ephedrine FDA Label
19	Loratadine FDA Label
20	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
21	Pheniramine FDA Label
22	Isoproterenol FDA Label
23	Promethazine FDA Label
24	Scopolamine FDA Label
25	Tripelennamine FDA Label
26	Beclomethasone dipropionate FDA Label
27	Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1. Cell Chem Biol. 2020 Jul 16;27(7):780-792.e5.
28	Phenylpropanolamine FDA Label
29	Mucin mRNA expression in normal and vasomotor inferior turbinates.Am J Rhinol. 1997 Jul-Aug;11(4):293-302. doi: 10.2500/105065897781446685.