Details of the Drug

General Information of Drug (ID: DMFOVSD)

Drug Name

Brompheniramine

Synonyms

Bromfed; Bromfenex; Bromfeniramina; Brotane; Parabromdylamine; BROMFED-DM; Bromfeniramina [INN-Spanish]; Brompheniramine (INN); Brompheniramine [INN:BAN]; Brompheniraminum [INN-Latin]; Brotane (TN); DIMETANE-DX; P-Bromdylamine; Para-Bromdylamine; Brompheniramine Maleate (1:1); [3-(4-Bromophenyl)-3-(2-pyridyl)propyl]dimethylamine; Gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine; 1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine; 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; 3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1], [2]

Therapeutic Class

Antiallergic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

319.24

Topological Polar Surface Area (xlogp)

3.5

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption: The drug is well absorbed from the gastrointestinal tract [3]
Bioavailability: 89% of drug becomes completely available to its intended biological destination(s) [4]
Metabolism: The drug is metabolized via the hepatic [3]

Chemical Identifiers

Formula: C16H19BrN2
IUPAC Name: 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Canonical SMILES: CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChI: InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InChIKey: ZDIGNSYAACHWNL-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 6834
ChEBI ID: CHEBI:3183
CAS Number: 86-22-6
DrugBank ID: DB00835
TTD ID: D08VXO

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Allergic rhinitis

ICD Disease Classification

CA08.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Brompheniramine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[14]
Methdilazine	DMAUHQX	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[14]
Trimeprazine	DMEMV9D	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[15]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[14]
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Coadministration of a Drug Treating the Disease Different from Brompheniramine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[15]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[15]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Memantine.	Alzheimer disease [8A20]	[14]
Rivastigmine	DMG629M	Moderate	Antagonize the effect of Brompheniramine when combined with Rivastigmine.	Alzheimer disease [8A20]	[16]
Donepezil	DMIYG7Z	Moderate	Antagonize the effect of Brompheniramine when combined with Donepezil.	Alzheimer disease [8A20]	[16]
Desipramine	DMT2FDC	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[14]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Cariprazine.	Bipolar disorder [6A60]	[14]
Loperamide	DMOJZQ9	Moderate	Additive antimotility effects by the combination of Brompheniramine and Loperamide.	Bowel habit change [ME05]	[17]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Brompheniramine when combined with Acetylcholine.	Cataract [9B10]	[18]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[19]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[19]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[19]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Ethanol.	Cystitis [GC00]	[20]
Cyclobenzaprine	DM1YBRM	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[14]
Isocarboxazid	DMAF1NB	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Isocarboxazid.	Depression [6A70-6A7Z]	[21]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and OPC-34712.	Depression [6A70-6A7Z]	[14]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Clomipramine.	Depression [6A70-6A7Z]	[14]
Doxepin	DMPI98T	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Doxepin.	Depression [6A70-6A7Z]	[15]
Maprotiline	DMPWB7T	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Maprotiline.	Depression [6A70-6A7Z]	[14]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Esketamine.	Depression [6A70-6A7Z]	[22]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Mepenzolate.	Digestive system disease [DE2Z]	[14]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Oxybutynine.	Discovery agent [N.A.]	[14]
Zonisamide	DM0DTF7	Major	Additive CNS depression effects by the combination of Brompheniramine and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[23]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[14]
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Solifenacin.	Functional bladder disorder [GC50]	[14]
Tolterodine	DMSHPW8	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Tolterodine.	Functional bladder disorder [GC50]	[14]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Brompheniramine when combined with Pilocarpine.	Glaucoma [9C61]	[18]
Procarbazine	DMIK367	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Procarbazine.	Hodgkin lymphoma [2B30]	[21]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[14]
Amantadine	DMS3YE9	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Amantadine.	Influenza [1E30-1E32]	[24]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and ITI-007.	Insomnia [7A00-7A0Z]	[14]
Physostigmine	DM2N0TO	Moderate	Antagonize the effect of Brompheniramine when combined with Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[16]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[25]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Lasmiditan.	Migraine [8A80]	[26]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Flibanserin.	Mood disorder [6A60-6E23]	[27]
Thalidomide	DM70BU5	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Thalidomide.	Multiple myeloma [2A83]	[28]
Ozanimod	DMT6AM2	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Ozanimod.	Multiple sclerosis [8A40]	[21]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Phenindamine.	Nasopharyngitis [CA00]	[14]
Dimenhydrinate	DM264B3	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Dimenhydrinate.	Nausea/vomiting [MD90]	[14]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Promethazine.	Nausea/vomiting [MD90]	[14]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Cyclizine.	Nausea/vomiting [MD90]	[14]
Apraclonidine	DMO4PVE	Moderate	Additive CNS depression effects by the combination of Brompheniramine and Apraclonidine.	Optic nerve disorder [9C40]	[29]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Flavoxate.	Pain [MG30-MG3Z]	[14]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Orphenadrine.	Parkinsonism [8A00]	[14]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Methylscopolamine.	Peptic ulcer [DA61]	[14]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Levomepromazine.	Psychotic disorder [6A20-6A25]	[14]
Quetiapine	DM1N62C	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Quetiapine.	Schizophrenia [6A20]	[14]
Mesoridazine	DM2ZGAN	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Mesoridazine.	Schizophrenia [6A20]	[14]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Aripiprazole.	Schizophrenia [6A20]	[14]
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Iloperidone.	Schizophrenia [6A20]	[14]
Paliperidone	DM7NPJS	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Paliperidone.	Schizophrenia [6A20]	[14]
Perphenazine	DMA4MRX	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Perphenazine.	Schizophrenia [6A20]	[14]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Molindone.	Schizophrenia [6A20]	[14]
Thiothixene	DMDINC4	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Thiothixene.	Schizophrenia [6A20]	[14]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Asenapine.	Schizophrenia [6A20]	[14]
Pimozide	DMW83TP	Moderate	Additive anticholinergic effects by the combination of Brompheniramine and Pimozide.	Schizophrenia [6A20]	[14]
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⏷ Show the Full List of 56 DDI Information of This Drug

References

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