Details of the Drug

General Information of Drug (ID: DM7SWIA)

Drug Name

Triprolidine

Synonyms

Actidil; Actidilat; Entra; Histafed; Myidyl; Tripolidina; Triprolidin; Triprolidinum; Venen; Triprolidine HCL; Triprolidine Monohydrochloride; Triprolidine hydrochloride; Triprolidine hydrochloride anhydrous; T 6764; Actidil (TN); Myidil (TN); Pro-Actidil; Pro-Entra; Tripolidina [INN-Spanish]; Triprolidine (INN); Triprolidine Hydrochloride (anhydrous); Triprolidine Monohydrochloride, Monohydrate; Triprolidine [INN:BAN]; Triprolidinum [INN-Latin]; Venen (TN); Trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine; Trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride; Trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene; Trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene; Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, monohydrate, stereoisomer; Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride; Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1); (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine; (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride; 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine chloride; 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine; 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Common cold	CA00	Approved	[1]
Hay fever	CA08.00	Approved	[2]
Seasonal allergic rhinitis	CA08.01	Approved	[1]
Urticaria	EB00-EB05	Approved	[1]
Vasomotor/allergic rhinitis	CA08	Approved	[1]
Pruritus	EC90	Investigative	[1]
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Therapeutic Class

Antiallergic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

278.4

Logarithm of the Partition Coefficient (xlogp)

3.9

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption: The drug is rapidly absorbed in the intestinal tract []
Half-life: The concentration or amount of drug in body reduced by one-half in 4 - 6 hours [3]

Chemical Identifiers

Formula: C19H22N2
IUPAC Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Canonical SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3
InChI: InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
InChIKey: CBEQULMOCCWAQT-WOJGMQOQSA-N

Cross-matching ID

PubChem CID: 5282443
ChEBI ID: CHEBI:84116
CAS Number: 486-12-4
DrugBank ID: DB00427
TTD ID: D0E8CI
VARIDT ID: DR01395
ACDINA ID: D00709

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[4]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

The Studied Disease

Allergic rhinitis

ICD Disease Classification

CA08.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43
P-glycoprotein 1 (ABCB1)	DTP	P-GP	6.54E-01	1.95E-01	4.04E-01

Molecular Expression Atlas (MEA)

MEA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Triprolidine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[6]
Methdilazine	DMAUHQX	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[6]
Carbinoxamine	DMCT31R	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Carbinoxamine.	Vasomotor/allergic rhinitis [CA08]	[6]
Trimeprazine	DMEMV9D	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[7]
Brompheniramine	DMFOVSD	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Brompheniramine.	Vasomotor/allergic rhinitis [CA08]	[6]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[6]
Azatadine	DMZ80SB	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Azatadine.	Vasomotor/allergic rhinitis [CA08]	[6]
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⏷ Show the Full List of 7 DDI Information of This Drug

Coadministration of a Drug Treating the Disease Different from Triprolidine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Scopolamine	DMOM8AL	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Scopolamine.	Addictive disorder [6C50-6C5Z]	[6]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[7]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[7]
Tripelennamine	DMZBU15	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Tripelennamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[6]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Memantine.	Alzheimer disease [8A20]	[6]
Galantamine	DMEO794	Moderate	Antagonize the effect of Triprolidine when combined with Galantamine.	Alzheimer disease [8A20]	[8]
Rivastigmine	DMG629M	Moderate	Antagonize the effect of Triprolidine when combined with Rivastigmine.	Alzheimer disease [8A20]	[8]
Donepezil	DMIYG7Z	Moderate	Antagonize the effect of Triprolidine when combined with Donepezil.	Alzheimer disease [8A20]	[8]
Hydroxyzine	DMF8Y74	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Hydroxyzine.	Anxiety disorder [6B00-6B0Z]	[6]
Desipramine	DMT2FDC	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[6]
Linezolid	DMGFPU2	Moderate	Additive CNS depression effects by the combination of Triprolidine and Linezolid.	Bacterial infection [1A00-1C4Z]	[9]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Cariprazine.	Bipolar disorder [6A60]	[6]
Loperamide	DMOJZQ9	Moderate	Additive antimotility effects by the combination of Triprolidine and Loperamide.	Bowel habit change [ME05]	[10]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Triprolidine when combined with Acetylcholine.	Cataract [9B10]	[11]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[12]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[12]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[12]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Triprolidine and Olopatadine.	Conjunctiva disorder [9A60]	[13]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Triprolidine and Ethanol.	Cystitis [GC00]	[13]
Cyclobenzaprine	DM1YBRM	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[6]
Imipramine	DM2NUH3	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Imipramine.	Depression [6A70-6A7Z]	[6]
Nortriptyline	DM4KDYJ	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Nortriptyline.	Depression [6A70-6A7Z]	[6]
Isocarboxazid	DMAF1NB	Moderate	Additive CNS depression effects by the combination of Triprolidine and Isocarboxazid.	Depression [6A70-6A7Z]	[9]
Tranylcypromine	DMGB5RE	Moderate	Additive CNS depression effects by the combination of Triprolidine and Tranylcypromine.	Depression [6A70-6A7Z]	[9]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Triprolidine and OPC-34712.	Depression [6A70-6A7Z]	[6]
Phenelzine	DMHIDUE	Moderate	Additive CNS depression effects by the combination of Triprolidine and Phenelzine.	Depression [6A70-6A7Z]	[9]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Clomipramine.	Depression [6A70-6A7Z]	[6]
Amoxapine	DMKITQE	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Amoxapine.	Depression [6A70-6A7Z]	[6]
Doxepin	DMPI98T	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Doxepin.	Depression [6A70-6A7Z]	[6]
Maprotiline	DMPWB7T	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Maprotiline.	Depression [6A70-6A7Z]	[6]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Triprolidine and Esketamine.	Depression [6A70-6A7Z]	[14]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Mepenzolate.	Digestive system disease [DE2Z]	[6]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Oxybutynine.	Discovery agent [N.A.]	[6]
Meclizine	DMS7T13	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Meclizine.	Dizziness and giddiness [MB48]	[6]
Zonisamide	DM0DTF7	Major	Increased risk of hyperpyrexia by the combination of Triprolidine and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[15]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[6]
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Solifenacin.	Functional bladder disorder [GC50]	[6]
Tolterodine	DMSHPW8	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Tolterodine.	Functional bladder disorder [GC50]	[6]
Darifenacin	DMWXLYZ	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Darifenacin.	Functional bladder disorder [GC50]	[6]
Propantheline	DM2EN6G	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Propantheline.	Gastric ulcer [DA60]	[6]
Isoflurophate	DMBSK7X	Moderate	Antagonize the effect of Triprolidine when combined with Isoflurophate.	Glaucoma [9C61]	[11]
Brimonidine	DMQLT4N	Moderate	Additive CNS depression effects by the combination of Triprolidine and Brimonidine.	Glaucoma [9C61]	[16]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Triprolidine when combined with Pilocarpine.	Glaucoma [9C61]	[11]
Procarbazine	DMIK367	Moderate	Additive CNS depression effects by the combination of Triprolidine and Procarbazine.	Hodgkin lymphoma [2B30]	[9]
Potassium chloride	DMMTAJC	Major	Increased risk of GI mucosal injury/bleeding risk by the combination of Triprolidine and Potassium chloride.	Hypo-kalaemia [5C77]	[17]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[6]
Amantadine	DMS3YE9	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Amantadine.	Influenza [1E30-1E32]	[18]
Propiomazine	DMKY8V1	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Propiomazine.	Insomnia [7A00-7A0Z]	[6]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Triprolidine and ITI-007.	Insomnia [7A00-7A0Z]	[6]
Clidinium	DMUMQZ0	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Clidinium.	Irritable bowel syndrome [DD91]	[6]
Dicyclomine	DMZSDGX	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Dicyclomine.	Irritable bowel syndrome [DD91]	[6]
Physostigmine	DM2N0TO	Moderate	Antagonize the effect of Triprolidine when combined with Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[8]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Triprolidine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[19]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Triprolidine and Lasmiditan.	Migraine [8A80]	[20]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Triprolidine and Flibanserin.	Mood disorder [6A60-6E23]	[21]
Thalidomide	DM70BU5	Moderate	Additive CNS depression effects by the combination of Triprolidine and Thalidomide.	Multiple myeloma [2A83]	[22]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Phenindamine.	Nasopharyngitis [CA00]	[6]
Dimenhydrinate	DM264B3	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Dimenhydrinate.	Nausea/vomiting [MD90]	[6]
Prochlorperazine	DM53SRA	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Prochlorperazine.	Nausea/vomiting [MD90]	[6]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Promethazine.	Nausea/vomiting [MD90]	[6]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Cyclizine.	Nausea/vomiting [MD90]	[6]
Apraclonidine	DMO4PVE	Moderate	Additive CNS depression effects by the combination of Triprolidine and Apraclonidine.	Optic nerve disorder [9C40]	[16]
Dextropropoxyphene	DM23HCX	Major	Decreased metabolism of Triprolidine caused by Dextropropoxyphene mediated inhibition of CYP450 enzyme.	Pain [MG30-MG3Z]	[23]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Flavoxate.	Pain [MG30-MG3Z]	[6]
Biperiden	DME78OA	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Biperiden.	Parkinsonism [8A00]	[6]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Orphenadrine.	Parkinsonism [8A00]	[6]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Methylscopolamine.	Peptic ulcer [DA61]	[6]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Levomepromazine.	Psychotic disorder [6A20-6A25]	[6]
Fluphenazine	DMIT8LX	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Fluphenazine.	Psychotic disorder [6A20-6A25]	[6]
Triflupromazine	DMKFQJP	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Triflupromazine.	Psychotic disorder [6A20-6A25]	[6]
Cyproheptadine	DM92AH3	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Cyproheptadine.	Rheumatoid arthritis [FA20]	[6]
Quetiapine	DM1N62C	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Quetiapine.	Schizophrenia [6A20]	[6]
Mesoridazine	DM2ZGAN	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Mesoridazine.	Schizophrenia [6A20]	[6]
Thioridazine	DM35M8J	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Thioridazine.	Schizophrenia [6A20]	[6]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Aripiprazole.	Schizophrenia [6A20]	[6]
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Iloperidone.	Schizophrenia [6A20]	[6]
Paliperidone	DM7NPJS	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Paliperidone.	Schizophrenia [6A20]	[6]
Haloperidol	DM96SE0	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Haloperidol.	Schizophrenia [6A20]	[6]
Perphenazine	DMA4MRX	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Perphenazine.	Schizophrenia [6A20]	[6]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Molindone.	Schizophrenia [6A20]	[6]
Chlorpromazine	DMBGZI3	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Chlorpromazine.	Schizophrenia [6A20]	[6]
Trifluoperazine	DMKBYWI	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Trifluoperazine.	Schizophrenia [6A20]	[6]
Risperidone	DMN6DXL	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Risperidone.	Schizophrenia [6A20]	[6]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Asenapine.	Schizophrenia [6A20]	[6]
Pimozide	DMW83TP	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Pimozide.	Schizophrenia [6A20]	[6]
Tizanidine	DMR2IQ4	Moderate	Additive CNS depression effects by the combination of Triprolidine and Tizanidine.	Tonus and reflex abnormality [MB47]	[24]
Atropine	DMEN6X7	Moderate	Additive anticholinergic effects by the combination of Triprolidine and Atropine.	Unspecific substance harmful effect [NE6Z]	[6]
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Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Sucralose	E00370	71485	Flavoring agent
Magnesium stearate	E00208	11177	lubricant
Xylitol	E00136	6912	Coating agent; Diluent; Emollient; Flavoring agent; Humectant
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Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Triprolidine 1.25 mg tablet	1.25 mg	Chewable Tablet	Oral

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References

1	Ephedrine FDA Label
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15	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
16	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
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19	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
20	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
21	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
22	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
23	Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
24	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.