Details of Disease

General Information of Disease (ID: DISKLMN7)

Disease Name Rhinitis
Synonyms runny nose; nasal cavity mucosa inflammation; inflammation of nasal cavity mucosa
Disease Class FA20: Rheumatoid arthritis
Definition An inflammation of the mucous membrane lining the nose, usually associated with nasal discharge.
Disease Hierarchy
DISWD40R: Disease
DISC0DZ3: Nasal cavity disorder
DIS3FXDI: Mucositis
DISKLMN7: Rhinitis
ICD Code
ICD-11
ICD-11: FA20
ICD-10
ICD-10: J31.0
Expand ICD-11
'CA09.0
Expand ICD-10
'J31.0
Expand ICD-9
472.0,477
Disease Identifiers
MONDO ID
MONDO_0003014
MESH ID
D012220
UMLS CUI
C0035455
MedGen ID
19782
HPO ID
HP:0012384
SNOMED CT ID
70076002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 14 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Chlophedianol DMXGJEI Approved Small molecular drug [1]
Codeine DMJX6ZG Approved Small molecular drug [2]
Cyproheptadine DM92AH3 Approved Small molecular drug [3]
Dexchlorpheniramine Maleate DMA8DPN Approved Small molecular drug [3]
Dextromethorphan DMUDJZM Approved Small molecular drug [4]
Ephedrine DMMV0KW Approved Small molecular drug [5]
Epoprostenol DMUTYR2 Approved Small molecular drug [6]
Glycine DMIOZ29 Approved Small molecular drug [7]
Hydrocodone DMQ2JO5 Approved Small molecular drug [8]
Phenylephrine DMZHUO5 Approved Small molecular drug [9]
Pseudoephedrine DMIVJ0D Approved Small molecular drug [5]
Simvastatin DM30SGU Approved Small molecular drug [10]
Beclomethasone dipropionate DM5NW1E Phase 4 NA [11]
Dihydrocodeine DMB0FWL Phase 4 Small molecular drug [12]
------------------------------------------------------------------------------------
⏷ Show the Full List of 14 Drug(s)
This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Andolast DMX36BH Phase 3 Small molecular drug [13]
AWD-12-281 DMVADGZ Phase 2 Small molecular drug [14]
ETIPREDNOL DICLOACETATE DM68K39 Phase 2 Small molecular drug [15]
SB-705498 DMRYHWI Phase 2 Small molecular drug [16]
UCB-35440 DM5Z34K Phase 2 NA [17]
AVP-13358 DM8CYJ1 Phase 1 Small molecular drug [18]
Synthetic neutrophil inhibitor peptide DM83E5B Phase 1 Small molecular drug [19]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 7 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Phenylpropanolamine DMTFK3O Withdrawn from market Small molecular drug [20]
EFLETIRIZINE DM2BT1H Discontinued in Phase 2 Small molecular drug [21]
GW-215864 DMI0OS7 Discontinued in Phase 2 Small molecular drug [22]
HSR-609 DM1PJ0V Discontinued in Phase 2 Small molecular drug [23]
Linetastine DMF8B62 Discontinued in Phase 2 Small molecular drug [24]
NPC-567 DMAVZ1F Discontinued in Phase 2 Small molecular drug [25]
S-5751 DM2X6ME Discontinued in Phase 2 Small molecular drug [26]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
RT-401 DMVQ3UH Investigative NA [27]
SODIUM CITRATE DMHPD2Y Investigative Small molecular drug [28]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 24 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
HNMT TT2B6EV Limited Genetic Variation [29]
HRH1 TTTIBOJ Limited Biomarker [30]
NRG1 TTEH395 Limited Biomarker [31]
SCGB1A1 TTONPVW Limited Altered Expression [32]
TBXA2R TT2O84V Limited Genetic Variation [33]
CFTR TTRLZHP moderate Biomarker [34]
IL13 TT0GVCH moderate Genetic Variation [35]
NPY TT64REZ moderate Biomarker [36]
VIP TTGTWLF moderate Biomarker [36]
ADAM33 TTQICM2 Strong Genetic Variation [37]
AOC1 TTM3B5R Strong Genetic Variation [29]
BDKRB1 TTG5QIA Strong Altered Expression [38]
BDNF TTSMLOH Strong Biomarker [39]
C3 TTJGY7A Strong Biomarker [40]
CCL11 TTCF05Y Strong Biomarker [41]
CCR3 TTD3XFU Strong Biomarker [42]
HDC TTV9GOF Strong Genetic Variation [43]
IL4 TTLGTKB Strong Altered Expression [44]
IL4R TTDWHC3 Strong Genetic Variation [35]
IL5 TTPREZD Strong Altered Expression [45]
MUC5AC TTEL90S Strong Biomarker [42]
OPA1 TTTU49Q Strong Biomarker [46]
PTGDR2 TTQDMX5 Strong Biomarker [47]
SCGB2A2 TT1W3RE Strong Biomarker [48]
------------------------------------------------------------------------------------
⏷ Show the Full List of 24 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC5A8 DTE3TAW Strong Biomarker [49]
------------------------------------------------------------------------------------
This Disease Is Related to 20 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ECSCR OT9L72MD Limited Biomarker [31]
ANKHD1 OTVYQ7ZL Strong Biomarker [50]
CCL13 OTNX0JD0 Strong Altered Expression [51]
DBNL OTT2OQOV Strong Genetic Variation [29]
FCER1A OTIRUOHF Strong Biomarker [52]
FEV OTYEC4IR Strong Genetic Variation [53]
FIS1 OT2HL10J Strong Biomarker [46]
FLG OTE9QDV6 Strong Genetic Variation [54]
FOXJ1 OT7LLBZ7 Strong Genetic Variation [55]
IFNLR1 OTWWWK45 Strong Genetic Variation [56]
KLK11 OT5PKX7Y Strong Biomarker [57]
MFN1 OTCBXQZF Strong Biomarker [46]
NFIA OTDHQ9CG Strong Genetic Variation [58]
ORMDL3 OTAB7MZF Strong Genetic Variation [59]
PGP OT6QQ7OR Strong Genetic Variation [60]
RNASE1 OTKZ7CO9 Strong Biomarker [61]
RSPH4A OTNDPGEE Strong Biomarker [62]
SERPINF2 OTZGAF8B Strong Biomarker [63]
SIT1 OT7MDF09 Strong Biomarker [64]
STK26 OTW4QE0D Strong Biomarker [50]
------------------------------------------------------------------------------------
⏷ Show the Full List of 20 DOT(s)

References

1 Chlophedianol FDA Label
2 Codeine FDA Label
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Dextromethorphan FDA Label
5 Ephedrine FDA Label
6 Epoprostenol FDA Label
7 Glycine FDA Label
8 Hydrocodone FDA Label
9 Isoproterenol FDA Label
10 Simvastatin FDA Label
11 Beclomethasone dipropionate FDA Label
12 Caffeine FDA Label
13 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002324)
14 ClinicalTrials.gov (NCT00354510) Topical GW842470X In Adults Patients With Moderate Atopic Dermatitis. U.S. National Institutes of Health.
15 ClinicalTrials.gov (NCT00035503) Multicenter Trial For Patients With Acute Crohn's Disease. U.S. National Institutes of Health.
16 ClinicalTrials.gov (NCT01424514) SB705498 Proof of Concept Chamber Challenge in Subjects With Non Allergic Rhinitis. U.S. National Institutes of Health.
17 Clinical pipeline report, company report or official report of UCB.
18 AVANIR Reports Positive Interim Phase I Safety Data on Asthma/Allergy Drug Candidate; Potential Asthma/Allergy Product Modulates IgE and Th2 Cytokines Orally
19 Attenuation of interleukin 8-induced nasal inflammation by an inhibitor peptide. Am J Respir Crit Care Med. 2001 Apr;163(5):1198-205.
20 Phenylpropanolamine FDA Label
21 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005395)
22 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010130)
23 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005369)
24 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002311)
25 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 676).
26 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1898).
27 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
28 SODIUM CITRATE FDA Label
29 Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis.Clin Exp Allergy. 2007 Aug;37(8):1175-82. doi: 10.1111/j.1365-2222.2007.02769.x.
30 Localization and upregulation of the nasal histamine H1 receptor in perennial allergic rhinitis.Mediators Inflamm. 2012;2012:951316. doi: 10.1155/2012/951316. Epub 2012 Oct 23.
31 Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma.Clin Transl Allergy. 2019 Mar 11;9:16. doi: 10.1186/s13601-019-0252-0. eCollection 2019.
32 The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis.Clin Exp Allergy. 2011 Jun;41(6):794-800. doi: 10.1111/j.1365-2222.2010.03679.x. Epub 2011 Jan 24.
33 Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma.Int J Immunogenet. 2012 Feb;39(1):20-5. doi: 10.1111/j.1744-313X.2011.01051.x. Epub 2011 Oct 21.
34 Cystic fibrosis gene mutations and chronic rhinosinusitis.J Allergy Clin Immunol. 2005 Aug;116(2):463. doi: 10.1016/j.jaci.2005.03.032.
35 Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms.Rev Port Pneumol (2006). 2017 Jan-Feb;23(1):10-16. doi: 10.1016/j.rppnen.2016.06.009. Epub 2016 Aug 22.
36 Toxic rhinitis-induced changes of human nasal mucosa innervation.Toxicol Pathol. 2003 May-Jun;31(3):326-31. doi: 10.1080/01926230390204379.
37 Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.BMC Med Genet. 2008 Sep 9;9:82. doi: 10.1186/1471-2350-9-82.
38 Up-regulation of functional kinin B1 receptors in allergic airway inflammation.J Immunol. 2002 Aug 15;169(4):2054-60. doi: 10.4049/jimmunol.169.4.2054.
39 [Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Mar;24(5):224-6.
40 [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Dec;41(12):928-31.
41 Effects of cryptoporus polysaccharide on rat allergic rhinitis associated with inhibiting eotaxin mRNA expression.J Ethnopharmacol. 2006 Oct 11;107(3):424-30. doi: 10.1016/j.jep.2006.03.040. Epub 2006 Apr 18.
42 Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.Cytokine. 2010 Dec;52(3):194-202. doi: 10.1016/j.cyto.2010.07.005. Epub 2010 Aug 8.
43 Variability of the L-Histidine decarboxylase gene in allergic rhinitis.Allergy. 2010 Dec;65(12):1576-84. doi: 10.1111/j.1398-9995.2010.02425.x.
44 Pro and Anti-inflammatory Cytokine Production in CD4+ T Lymphocytes in Children with Asthma and Allergic Rhinitis Exposed to the Monocyte Locomotion Inhibitory Factor (MLIF).Iran J Allergy Asthma Immunol. 2018 Aug 12;17(4):388-392. doi: 10.18502/ijaai.v17i4.98.
45 Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils.Clin Exp Allergy. 2000 Dec;30(12):1709-16. doi: 10.1046/j.1365-2222.2000.00998.x.
46 PM(2.5)-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats.Int J Environ Res Public Health. 2017 Jan 29;14(2):134. doi: 10.3390/ijerph14020134.
47 Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma.Comb Chem High Throughput Screen. 2019;22(8):521-533. doi: 10.2174/1386207322666190919113006.
48 Nasal mucosal gene expression in patients with allergic rhinitis with and without nasal polyps.J Allergy Clin Immunol. 2003 Dec;112(6):1057-63. doi: 10.1016/j.jaci.2003.09.042.
49 Decision-making for pediatric allergy immunotherapy for aeroallergens: a narrative review.Eur J Pediatr. 2019 Dec;178(12):1801-1812. doi: 10.1007/s00431-019-03444-2. Epub 2019 Aug 14.
50 Interactions Between Air Pollution and Pollen Season for Rhinitis Using Mobile Technology: A MASK-POLLAR Study.J Allergy Clin Immunol Pract. 2020 Mar;8(3):1063-1073.e4. doi: 10.1016/j.jaip.2019.11.022. Epub 2019 Nov 28.
51 Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids.J Allergy Clin Immunol. 1999 Jun;103(6):1036-44. doi: 10.1016/s0091-6749(99)70176-4.
52 Enhanced expression of high-affinity IgE receptor (Fc epsilon RI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells.J Allergy Clin Immunol. 1997 Jul;100(1):78-86. doi: 10.1016/s0091-6749(97)70198-2.
53 Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes.Immunogenetics. 2005 Apr;57(1-2):25-32. doi: 10.1007/s00251-005-0778-2. Epub 2005 Mar 3.
54 Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clin Exp Allergy. 2019 Nov;49(11):1475-1486. doi: 10.1111/cea.13485. Epub 2019 Oct 15.
55 Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.J Hum Genet. 2006;51(4):292-297. doi: 10.1007/s10038-006-0359-8. Epub 2006 Mar 4.
56 Analysis of the variations in IL-28RA gene and their association with allergic rhinitis.Exp Mol Med. 2006 Jun 30;38(3):302-9. doi: 10.1038/emm.2006.36.
57 The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis.Immunotherapy. 2017 Mar;9(4):331-337. doi: 10.2217/imt-2016-0131.
58 The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype.J Allergy Clin Immunol. 2014 Sep;134(3):576-582.e1. doi: 10.1016/j.jaci.2013.12.1074. Epub 2014 Feb 20.
59 A polymorphism in ORMDL3 is associated not only with asthma without rhinitis but also with chronic obstructive pulmonary disease.J Investig Allergol Clin Immunol. 2013;23(4):256-61.
60 Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.Laryngoscope. 2007 Sep;117(9):1519-27. doi: 10.1097/MLG.0b013e3180ca7846.
61 Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.PLoS Pathog. 2017 Feb 6;13(2):e1006197. doi: 10.1371/journal.ppat.1006197. eCollection 2017 Feb.
62 RSPH3 Mutations Cause Primary Ciliary Dyskinesia with Central-Complex Defects and a Near Absence of Radial Spokes. Am J Hum Genet. 2015 Jul 2;97(1):153-62. doi: 10.1016/j.ajhg.2015.05.004. Epub 2015 Jun 11.
63 Differences between preschoolers with asthma and allergies in urban and rural environments.J Asthma. 2018 May;55(5):470-476. doi: 10.1080/02770903.2017.1339800. Epub 2017 Jul 21.
64 Specific immunotherapy in allergic rhinitis.Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Sep;134(4):253-258. doi: 10.1016/j.anorl.2017.06.005. Epub 2017 Jul 3.