Details of Disease

General Information of Disease (ID: DISIBXJ3)

• Disease Name: Ventricular tachycardia
• Disease Class: BC71: Ventricular tachyarrhythmia
• Definition: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)
• Disease Hierarchy:
  DIS1W8PP: Tachyarrhythmias
  DISIBXJ3: Ventricular tachycardia
• ICD Code:
  ICD-11: ICD-11: BC71
  ICD-10: ICD-10: I47
  Expand ICD-11: BC71.0; BC65.5
  Expand ICD-10: I47
• Disease Identifiers:
  MONDO ID: MONDO_0005477
  MESH ID: D017180
  UMLS CUI: C0042514
  MedGen ID: 12068
  HPO ID: HP:0004756
  SNOMED CT ID: 25569003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amiodarone	DMUTEX3	Approved	Small molecular drug	[1]
Mexiletine	DMCTE9R	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 15 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCC9	TTEF5MJ	Limited	Biomarker	[3]
EPO	TTQG4NR	Limited	Therapeutic	[4]
KCNJ2	TTH7UO3	Limited	Biomarker	[5]
NOS3	TTCM4B3	Limited	Therapeutic	[6]
NPPB	TTY63XT	Limited	Biomarker	[7]
SCN4A	TT84DRB	Limited	Biomarker	[8]
TNNT2	TTWAS18	Limited	Biomarker	[9]
HCN4	TTQP04A	moderate	Genetic Variation	[10]
CALCR	TTLWS2O	Strong	Genetic Variation	[11]
CALR	TTUZ7OA	Strong	Genetic Variation	[11]
GNAQ	TTL1SRG	Strong	Genetic Variation	[12]
KCNH2	TTQ6VDM	Strong	Genetic Variation	[13]
PLN	TTMCVJF	Strong	Genetic Variation	[14]
SCN5A	TTZOVE0	Strong	Genetic Variation	[15]
SLC6A8	TTYUHB5	Strong	Genetic Variation	[11]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
KCNK2	DTENHUP	Limited	Genetic Variation	[16]

This Disease Is Related to 27 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KCNIP2	OTY4BLOJ	Limited	Biomarker	[17]
KCNJ8	OTZ8G8FE	Limited	Biomarker	[18]
SCN4B	OT3JSUWO	Limited	Genetic Variation	[19]
PKP2	OTJOVF68	Disputed	Genetic Variation	[20]
LUC7L3	OTKDED8A	moderate	Genetic Variation	[21]
MTMR11	OTHL2O08	moderate	Genetic Variation	[21]
RYR2	OT0PF19E	moderate	Biomarker	[22]
ACTN2	OT9FOLD7	Strong	Genetic Variation	[23]
ANK2	OTWB4R1Y	Strong	Genetic Variation	[24]
CASQ2	OT09MNQ8	Strong	Altered Expression	[25]
DSG2	OTJPB2TO	Strong	Genetic Variation	[26]
DSP	OTB2MOP8	Strong	Genetic Variation	[27]
ELOA	OTOQTF5K	Strong	Biomarker	[28]
ELOB	OTZ3X84T	Strong	Biomarker	[28]
ELOC	OT0XHHWP	Strong	Biomarker	[28]
FGF12	OTBM9QIO	Strong	Altered Expression	[29]
FKBP1B	OT8CMPB2	Strong	Biomarker	[30]
FKRP	OTMUZ7GH	Strong	Biomarker	[31]
FXR1	OTEMQ1SR	Strong	Biomarker	[32]
IRX3	OTLJ48FG	Strong	Genetic Variation	[33]
KCNE1	OTZNQUW9	Strong	Genetic Variation	[34]
LMNA	OT3SG7ZR	Strong	Genetic Variation	[35]
NOS1AP	OTDFOBRU	Strong	Genetic Variation	[36]
POU2F3	OTIOOJWD	Strong	Genetic Variation	[37]
RLN2	OTY3OG71	Strong	Biomarker	[38]
SKP1	OT5BPAZ4	Strong	Biomarker	[28]
TMEM43	OTM9RS9G	Strong	Genetic Variation	[39]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 204742.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Short QT syndrome.CMAJ. 2005 Nov 22;173(11):1349-54. doi: 10.1503/cmaj.050596.
• [4] Erythropoietin pretreatment protects against acute chemotherapy toxicity in isolated rat hearts.Exp Biol Med (Maywood). 2008 Jan;233(1):76-83. doi: 10.3181/0706-RM-152.
• [5] Transgenic upregulation of IK1 in the mouse heart is proarrhythmic.Basic Res Cardiol. 2007 Sep;102(5):416-28. doi: 10.1007/s00395-007-0659-y. Epub 2007 Jun 5.
• [6] In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice.J Cardiovasc Electrophysiol. 2001 Nov;12(11):1295-301. doi: 10.1046/j.1540-8167.2001.01295.x.
• [7] Low-dose nesiritide improves renal function in heart failure patients following acute myocardial infarction.Heart Vessels. 2010 Mar;25(2):97-103. doi: 10.1007/s00380-009-1171-0. Epub 2010 Mar 26.
• [8] Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):831-40. doi: 10.1161/CIRCEP.111.969907. Epub 2012 Jun 21.
• [9] Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.Circ Res. 2003 Mar 7;92(4):428-36. doi: 10.1161/01.RES.0000059562.91384.1A. Epub 2003 Feb 6.
• [10] Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 2009 Feb;54(2):115-21. doi: 10.1038/jhg.2008.16. Epub 2009 Jan 23.
• [11] Impact of ventricular tachycardia ablation on health care utilization.Heart Rhythm. 2018 Mar;15(3):355-362. doi: 10.1016/j.hrthm.2017.10.009. Epub 2017 Oct 10.
• [12] Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.J Am Heart Assoc. 2016 Nov 28;5(12):e003905. doi: 10.1161/JAHA.116.003905.
• [13] Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.Circ Res. 2014 Nov 7;115(11):919-28. doi: 10.1161/CIRCRESAHA.115.305146. Epub 2014 Sep 23.
• [14] Outcome in phospholamban R14del carriers: results of a large multicentre cohort study.Circ Cardiovasc Genet. 2014 Aug;7(4):455-65. doi: 10.1161/CIRCGENETICS.113.000374. Epub 2014 Jun 8.
• [15] Genetic Variants on SCN5A, KCNQ1, and KCNH2 in Patients with Ventricular Arrhythmias during Acute Myocardial Infarction in a Chinese Population.Cardiology. 2020;145(1):38-45. doi: 10.1159/000502833. Epub 2019 Nov 21.
• [16] Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.EMBO Mol Med. 2017 Apr;9(4):403-414. doi: 10.15252/emmm.201606690.
• [17] A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.Cell. 2001 Dec 14;107(6):801-13. doi: 10.1016/s0092-8674(01)00588-8.
• [18] Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.J Cardiovasc Electrophysiol. 2016 Oct;27(10):1214-1219. doi: 10.1111/jce.13029. Epub 2016 Jul 13.
• [19] Identification of rare variants in cardiac sodium channel 4-subunit gene SCN4B associated with ventricular tachycardia.Mol Genet Genomics. 2019 Aug;294(4):1059-1071. doi: 10.1007/s00438-019-01567-7. Epub 2019 Apr 17.
• [20] Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents.J Am Coll Cardiol. 2019 Jul 23;74(3):346-358. doi: 10.1016/j.jacc.2019.05.022.
• [21] Postanoxic alpha, theta or alpha-theta coma: Clinical setting and neurological outcome.Resuscitation. 2018 Mar;124:118-125. doi: 10.1016/j.resuscitation.2017.12.022. Epub 2017 Dec 22.
• [22] Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts.Heart Rhythm. 2019 Apr;16(4):615-623. doi: 10.1016/j.hrthm.2018.10.033. Epub 2018 Nov 13.
• [23] Whole-Exome Sequencing Identifies a Novel Mutation (p.L320R) of Alpha-Actinin 2 in a Chinese Family with Dilated Cardiomyopathy and Ventricular Tachycardia.Cytogenet Genome Res. 2019;157(3):148-152. doi: 10.1159/000496077. Epub 2019 Jan 11.
• [24] Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.Circulation. 2018 Dec 4;138(23):2682-2697. doi: 10.1161/CIRCULATIONAHA.118.034541.
• [25] Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.Heart Rhythm. 2017 Jul;14(7):1053-1060. doi: 10.1016/j.hrthm.2017.03.025. Epub 2017 Mar 20.
• [26] Compound and heterozygous mutations of DSG2 identified by Whole Exome Sequencing in arrhythmogenic right ventricular cardiomyopathy/dysplasia with ventricular tachycardia.J Electrocardiol. 2018 Sep-Oct;51(5):837-843. doi: 10.1016/j.jelectrocard.2018.06.012. Epub 2018 Jun 20.
• [27] Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy.Heart Rhythm. 2011 Aug;8(8):1214-21. doi: 10.1016/j.hrthm.2011.03.015. Epub 2011 Mar 10.
• [28] Prediction of ventricular tachyarrhythmia in Brugada syndrome by right ventricular outflow tract conduction delay signs.J Cardiovasc Electrophysiol. 2018 Jul;29(7):998-1003. doi: 10.1111/jce.13496. Epub 2018 Apr 20.
• [29] De Novo FGF12 (Fibroblast Growth Factor 12) Functional Variation Is Potentially Associated With Idiopathic Ventricular Tachycardia.J Am Heart Assoc. 2017 Aug 3;6(8):e006130. doi: 10.1161/JAHA.117.006130.
• [30] Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.Proc Natl Acad Sci U S A. 2006 May 16;103(20):7906-10. doi: 10.1073/pnas.0602133103. Epub 2006 May 3.
• [31] Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy.Circ Genom Precis Med. 2018 Mar;11(3):e001893. doi: 10.1161/CIRCGEN.117.001893.
• [32] Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.Circulation. 2018 Feb 6;137(6):605-618. doi: 10.1161/CIRCULATIONAHA.117.028976. Epub 2017 Nov 3.
• [33] A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.BMC Med Genet. 2013 Mar 20;14:36. doi: 10.1186/1471-2350-14-36.
• [34] Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes.BMC Evol Biol. 2009 Aug 6;9:188. doi: 10.1186/1471-2148-9-188.
• [35] Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies.Circulation. 2019 Jul 23;140(4):293-302. doi: 10.1161/CIRCULATIONAHA.118.039410. Epub 2019 Jun 3.
• [36] The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations.Sci Rep. 2017 Aug 21;7(1):8356. doi: 10.1038/s41598-017-08548-z.
• [37] Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease.Cardiovasc Ther. 2017 Oct;35(5). doi: 10.1111/1755-5922.12288.
• [38] Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties.Int J Cardiol. 2018 Jan 1;250:21-28. doi: 10.1016/j.ijcard.2017.09.017.
• [39] Ventricular tachycardia ablation in arrhythmogenic right ventricular cardiomyopathy patients with TMEM43 gene mutations.J Cardiovasc Electrophysiol. 2018 Jan;29(1):90-97. doi: 10.1111/jce.13353. Epub 2017 Oct 26.