Details of Disease

General Information of Disease (ID: DISIMBN2)

• Disease Name: Varicose veins
• Synonyms: varicose veins; varices; Venous ectasia; varix; Venous varices
• Disease Class: BD74-BD75: Varicose veins
• Definition: A vascular disease characterized by the presence of enlarged and tortuous veins.
• Disease Hierarchy:
  DISJQJNZ: Vein disorder
  DISWD40R: Disease
  DISIMBN2: Varicose veins
• ICD Code:
  ICD-11: ICD-11: BD74-BD75
  ICD-10: ICD-10: I83.10
• Disease Identifiers:
  MONDO ID: MONDO_0008638
  MESH ID: D014648
  UMLS CUI: C0042345
  OMIM ID: 192200
  MedGen ID: 21827
  HPO ID: HP:0002619
  SNOMED CT ID: 128060009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Polidocanol	DMH1KMT	Approved	Small molecular drug	[1]
Polidocanol - BioForm Medical/Chemische Fabrik Kreussler & Co	DMUCWEX	Approved	Small molecular drug	[2]
Sodium Tetradecyl Sulfate	DM4QFXJ	Approved	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 16 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KCNN3	TT9JH25	Limited	Biomarker	[4]
TNC	TTUCPMY	Limited	Biomarker	[5]
CNGB3	TT0LJCG	moderate	Genetic Variation	[6]
FOXC2	TTLBAP1	moderate	Altered Expression	[7]
HDAC7	TTMUEK1	moderate	Genetic Variation	[8]
HLA-A	TTHONFT	moderate	Genetic Variation	[6]
BACE2	TT69DB8	Strong	Biomarker	[9]
DBH	TTYIP79	Strong	Biomarker	[10]
DCLK3	TTMYK4Z	Strong	Biomarker	[11]
F13B	TTAXGIP	Strong	Altered Expression	[12]
GJA8	TTJ7ATH	Strong	Biomarker	[13]
PEPD	TTLZXI0	Strong	Altered Expression	[14]
PORCN	TTNFBTO	Strong	Biomarker	[15]
SNCA	TT08OSU	Strong	Altered Expression	[16]
USH2A	TTVCLLA	Strong	Genetic Variation	[17]
VHL	TTEMWSD	Strong	Biomarker	[18]

This Disease Is Related to 5 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC12A2	DTHKL3Q	moderate	Genetic Variation	[8]
SLC17A6	DT5LHCR	Strong	Biomarker	[19]
SLC17A7	DTNK0FR	Strong	Biomarker	[20]
SLC17A8	DTAGDH7	Strong	Biomarker	[21]
SLC32A1	DTXQYLR	Strong	Biomarker	[22]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP4A11	DE2XQGW	Strong	Altered Expression	[23]
CYP4F2	DE3GT9C	Strong	Biomarker	[23]

This Disease Is Related to 36 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DPT	OTINRFC7	Limited	Biomarker	[5]
MGP	OTZWU3FU	Limited	Altered Expression	[5]
TIMP1	OTOXC51H	Limited	Biomarker	[5]
ADI1	OT8IOD03	moderate	Biomarker	[24]
EBF1	OTZ61YYH	moderate	Genetic Variation	[8]
GLG1	OT7X0W3N	moderate	Genetic Variation	[6]
LBH	OT87AT1X	moderate	Genetic Variation	[6]
NFATC2	OTK5T6HZ	moderate	Genetic Variation	[8]
PIEZO1	OTBG1FU4	moderate	Genetic Variation	[8]
PRKAR1B	OT777OHS	moderate	Genetic Variation	[6]
BLOC1S2	OTUR3E76	Strong	Biomarker	[25]
CACYBP	OTJMZD2T	Strong	Biomarker	[26]
CALB1	OTM7IXDG	Strong	Biomarker	[19]
CASZ1	OTWJ2OR8	Strong	Genetic Variation	[8]
CBLN4	OTO7QW6Y	Strong	Biomarker	[27]
DOCK3	OTF3YS2W	Strong	Biomarker	[13]
ERC1	OTYBGGNO	Strong	Biomarker	[28]
EXOC7	OT4YA137	Strong	Biomarker	[29]
EXOSC3	OTNCF906	Strong	Biomarker	[30]
GNG13	OTFOFWEU	Strong	Biomarker	[31]
HEY2	OTU4J3ZI	Strong	Altered Expression	[32]
HOMER1	OTWFD3SI	Strong	Biomarker	[33]
KANK2	OT3SZIWM	Strong	Biomarker	[26]
LAD1	OT6YGTVX	Strong	Genetic Variation	[34]
MCF2L2	OTOGFMIH	Strong	Biomarker	[35]
MFAP5	OT46VXSG	Strong	Biomarker	[36]
MYOCD	OTSJNHTH	Strong	Biomarker	[37]
PACSIN1	OT07Z2RQ	Strong	Biomarker	[38]
PAPLN	OTCJD85N	Strong	Biomarker	[15]
PGP	OT6QQ7OR	Strong	Biomarker	[39]
PRLH	OTJBP360	Strong	Biomarker	[40]
RBM14	OTO9GMBD	Strong	Biomarker	[26]
SYNM	OTOI8TRJ	Strong	Altered Expression	[41]
SYP	OTFJKMO4	Strong	Biomarker	[42]
TP53INP1	OT2363Z9	Strong	Biomarker	[26]
TSACC	OT3QW6PH	Strong	Biomarker	[26]

References

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