General Information of Disease (ID: DISVO82H)

Disease Name Vascular dementia
Synonyms multifocal dementia; multi infarct dementia; vascular dementia
Disease Class 6D80-6D8Z: Dementia
Definition A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Disease Hierarchy
DISAB237: Cerebrovascular disease
DISXL1WY: Dementia
DISVO82H: Vascular dementia
ICD Code
ICD-11
ICD-11: 6D81
Disease Identifiers
MONDO ID
MONDO_0004648
MESH ID
D015140
UMLS CUI
C0011269
MedGen ID
41447
SNOMED CT ID
429998004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Salvianolic acid B DMQVC3E Phase 2 Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 32 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ANK1 TTKFPMH Limited Posttranslational Modification [2]
F11 TTDM4ZU Limited Biomarker [3]
LPA TTU9LGY Limited Genetic Variation [4]
PSEN1 TTZ3S8C Disputed Genetic Variation [5]
BDNF TTSMLOH moderate Altered Expression [6]
SYK TT2HUPM moderate Genetic Variation [7]
ADRB1 TTR6W5O Strong Biomarker [8]
AVP TTJ8EWH Strong Biomarker [9]
CDK5 TTL4Q97 Strong Therapeutic [10]
CETP TTFQAYR Strong Genetic Variation [11]
CHAT TTKYFSB Strong Altered Expression [12]
CHRNA7 TTLA931 Strong Biomarker [13]
COASY TT4YO0Z Strong Biomarker [14]
DLG4 TT9PB26 Strong Altered Expression [15]
EIF4E TTZGCP6 Strong Biomarker [16]
EPHA4 TTG84D3 Strong Altered Expression [17]
EPO TTQG4NR Strong Genetic Variation [18]
FGFR1 TTRLW2X Strong Therapeutic [19]
FLT1 TT1VAUK Strong Therapeutic [19]
GPX1 TTYAHBP Strong Therapeutic [20]
GRIN1 TTLD29N Strong Altered Expression [21]
GSK3B TTRSMW9 Strong Biomarker [22]
GSTO1 TTWO3SH Strong Genetic Variation [23]
HTR6 TTJS8PY Strong Biomarker [24]
IGF1 TTT6LOU Strong Biomarker [25]
KRT6A TT2FX8W Strong Biomarker [26]
MAPT TTS87KH Strong Biomarker [27]
MCHR2 TTS17MG Strong Biomarker [28]
MTOR TTCJG29 Strong Biomarker [16]
NOTCH3 TTVX7IA Strong Genetic Variation [29]
PDE9A TTZOEBC Strong Biomarker [30]
SST TTWF7UG Strong Biomarker [31]
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⏷ Show the Full List of 32 DTT(s)
This Disease Is Related to 28 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PTCRA OTQTO5QZ Limited Biomarker [3]
SDHAF1 OTDG5VW7 Disputed Biomarker [32]
ADGRA2 OTBT4W36 Strong Biomarker [33]
ANGPT4 OT881M3K Strong Genetic Variation [34]
CD2AP OTC76KQM Strong Biomarker [35]
CFL2 OTE2W0DH Strong Biomarker [36]
CNTNAP2 OT48T2ZP Strong Genetic Variation [37]
CRLS1 OT7XNL0K Strong Altered Expression [38]
GFRA1 OT3WBVYB Strong Biomarker [39]
MASP1 OTWWCNZP Strong Biomarker [40]
MCIDAS OTK1JVAH Strong Biomarker [41]
MOAP1 OTVF3LUG Strong Biomarker [40]
NUBP1 OTE8RAKZ Strong Biomarker [14]
PLEK OTB73XXA Strong Biomarker [42]
RETREG1 OTYOSLZX Strong Biomarker [43]
RGN OTD04KB1 Strong Biomarker [44]
RIN3 OT5Z6F8O Strong Biomarker [35]
RPGRIP1 OTABESO9 Strong Genetic Variation [45]
RPGRIP1L OT6Z069I Strong Biomarker [45]
RPS6 OTT4D1LN Strong Therapeutic [46]
SPAG16 OTIFUPYD Strong Biomarker [47]
SUCLA2 OTMZD4PW Strong Altered Expression [48]
SYN1 OTMNPWC1 Strong Biomarker [49]
SYNM OTOI8TRJ Strong Biomarker [21]
SYP OTFJKMO4 Strong Altered Expression [15]
TNFRSF19 OTTVT4MB Strong Biomarker [43]
NMB OT4NLN6H Definitive Biomarker [50]
RASGRF2 OT67DAGF Definitive Genetic Variation [51]
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⏷ Show the Full List of 28 DOT(s)

References

1 ClinicalTrials.gov (NCT01761227) Efficacy and Safety of Fufangdanshen Tablets in Mild to Moderate Vascular Dementia. U.S. National Institutes of Health.
2 A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases.Neurobiol Aging. 2019 Feb;74:70-76. doi: 10.1016/j.neurobiolaging.2018.09.024. Epub 2018 Oct 13.
3 Midregional Proenkephalin A and N-terminal Protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation.J Neuroimmunol. 2010 Apr 15;221(1-2):62-7. doi: 10.1016/j.jneuroim.2010.02.004. Epub 2010 Mar 5.
4 Lipid metabolism in cognitive decline and dementia.Brain Res Rev. 2006 Aug;51(2):275-92. doi: 10.1016/j.brainresrev.2005.11.007. Epub 2006 Jan 10.
5 Presenilin gene predisposes to late-onset degenerative but not vascular dementia: a comparative study of PS1 and ApoE genes in a North Indian Cohort.Dement Geriatr Cogn Disord. 2007;24(3):151-61. doi: 10.1159/000105483. Epub 2007 Jul 10.
6 Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia.Physiol Behav. 2019 Mar 15;201:198-207. doi: 10.1016/j.physbeh.2018.12.012. Epub 2018 Dec 12.
7 Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia.World J Biol Psychiatry. 2013 Apr;14(3):220-6. doi: 10.3109/15622975.2011.559272. Epub 2011 Feb 28.
8 Acupuncture Prevents the Impairment of Hippocampal LTP Through 1-AR in Vascular Dementia Rats.Mol Neurobiol. 2018 Oct;55(10):7677-7690. doi: 10.1007/s12035-018-0943-x. Epub 2018 Feb 13.
9 Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats.Biomed Res Int. 2017;2017:3214918. doi: 10.1155/2017/3214918. Epub 2017 Nov 28.
10 The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):437-46. doi: 10.1093/abbs/gmw024.
11 Frequency of Cardiovascular Genetic Risk Factors in a Calabrian Population and Their Effects on Dementia.J Alzheimers Dis. 2018;61(3):1179-1187. doi: 10.3233/JAD-170687.
12 Genetic associations of autopsy-confirmed vascular dementia subtypes.Dement Geriatr Cogn Disord. 2011;31(4):247-53. doi: 10.1159/000327171. Epub 2011 Apr 7.
13 CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein 4 and Cigarette Smoking.Sci Rep. 2016 Jun 2;6:27231. doi: 10.1038/srep27231.
14 L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway.Eur Rev Med Pharmacol Sci. 2018 Aug;22(16):5377-5384. doi: 10.26355/eurrev_201808_15740.
15 Effects of autophagy on synaptic-plasticity-related protein expression in the hippocampus CA1 of a rat model of vascular dementia.Neurosci Lett. 2019 Aug 10;707:134312. doi: 10.1016/j.neulet.2019.134312. Epub 2019 Jun 1.
16 Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia.Neurol Sci. 2013 Jul;34(7):1093-7. doi: 10.1007/s10072-012-1209-4. Epub 2012 Oct 9.
17 Activation of EphA4 induced by EphrinA1 exacerbates disruption of the blood-brain barrier following cerebral ischemia-reperfusion via the Rho/ROCK signaling pathway.Exp Ther Med. 2018 Sep;16(3):2651-2658. doi: 10.3892/etm.2018.6460. Epub 2018 Jul 17.
18 Erythropoietin prevents dementia in hemodialysis patients: a nationwide population-based study.Aging (Albany NY). 2019 Sep 5;11(17):6941-6950. doi: 10.18632/aging.102227. Epub 2019 Sep 5.
19 [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats].Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Jan;32(1):97-101.
20 Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion.Mol Med Rep. 2014 Sep;10(3):1635-41. doi: 10.3892/mmr.2014.2355. Epub 2014 Jun 26.
21 The restoration after repetitive transcranial magnetic stimulation treatment on cognitive ability of vascular dementia rats and its impacts on synaptic plasticity in hippocampal CA1 area.J Mol Neurosci. 2010 May;41(1):145-55. doi: 10.1007/s12031-009-9311-7. Epub 2009 Dec 2.
22 Erythropoietin Rescues Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via the EPO-R/JAK2/STAT5/PI3K/Akt/GSK-3 Pathway.Mol Neurobiol. 2018 Apr;55(4):3290-3299. doi: 10.1007/s12035-017-0568-5. Epub 2017 May 9.
23 Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.Stroke. 2007 Oct;38(10):2847-50. doi: 10.1161/STROKEAHA.107.484162. Epub 2007 Aug 23.
24 Effect of Selective 5-HT6R Agonist on Expression of 5-HT Receptor and Neurotransmitter in Vascular Dementia Rats.Med Sci Monit. 2017 Feb 15;23:818-825. doi: 10.12659/msm.899067.
25 Salvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia.Cell Physiol Biochem. 2017;43(4):1381-1391. doi: 10.1159/000481849. Epub 2017 Oct 9.
26 Effect of glycosides of Cistanche on the expression of mitochondrial precursor protein and keratin type II cytoskeletal 6A in a rat model of vascular dementia.Neural Regen Res. 2017 Jul;12(7):1152-1158. doi: 10.4103/1673-5374.211196.
27 Evaluation of cerebrospinal fluid phosphorylated tau(231) as a biomarker in the differential diagnosis of Alzheimer's disease and vascular dementia.CNS Neurosci Ther. 2018 Aug;24(8):734-740. doi: 10.1111/cns.12814. Epub 2018 Feb 17.
28 Efficacy and safety of the compound Chinese medicine SaiLuoTong invascular dementia: A randomized clinical trial.Alzheimers Dement (N Y). 2018 Mar 22;4:108-117. doi: 10.1016/j.trci.2018.02.004. eCollection 2018.
29 Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease.J Psychiatr Res. 2019 Jun;113:141-147. doi: 10.1016/j.jpsychires.2019.03.026. Epub 2019 Mar 30.
30 Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.J Med Chem. 2019 Apr 25;62(8):4218-4224. doi: 10.1021/acs.jmedchem.8b01041. Epub 2019 Apr 3.
31 N-Terminal Prosomatostatin and Risk of Vascular Dementia.Cerebrovasc Dis. 2017;44(5-6):259-265. doi: 10.1159/000479940. Epub 2017 Aug 31.
32 SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat Genet. 2009 Jun;41(6):654-6. doi: 10.1038/ng.378. Epub 2009 May 24.
33 A Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia.Drug Des Devel Ther. 2019 Oct 23;13:3669-3682. doi: 10.2147/DDDT.S226473. eCollection 2019.
34 Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia.J Hum Genet. 2010 Oct;55(10):649-55. doi: 10.1038/jhg.2010.79. Epub 2010 Jul 1.
35 Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals.Eur J Epidemiol. 2019 Jun;34(6):579-590. doi: 10.1007/s10654-019-00498-2. Epub 2019 Mar 4.
36 Cofilin 2 in Serum as a Novel Biomarker for Alzheimer's Disease in Han Chinese.Front Aging Neurosci. 2019 Aug 9;11:214. doi: 10.3389/fnagi.2019.00214. eCollection 2019.
37 Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.Alzheimers Dement. 2019 Oct;15(10):1333-1347. doi: 10.1016/j.jalz.2019.06.4950. Epub 2019 Aug 28.
38 Involvement of Endothelin-1, H(2)S and Nrf2 in Beneficial Effects of Remote Ischemic Preconditioning in Global Cerebral Ischemia-Induced Vascular Dementia in Mice.Cell Mol Neurobiol. 2019 Jul;39(5):671-686. doi: 10.1007/s10571-019-00670-y. Epub 2019 Apr 25.
39 Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFR1/Ret Signaling Preventing Hippocampal Neuron Apoptosis.Front Cell Neurosci. 2019 Aug 13;13:351. doi: 10.3389/fncel.2019.00351. eCollection 2019.
40 N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia.J Pathol. 2019 Jul;248(3):291-303. doi: 10.1002/path.5254. Epub 2019 Mar 19.
41 Biomarker-Based Prediction of Progression to Dementia: F-18 FDG-PET in Amnestic MCI.Neurol India. 2019 Sep-Oct;67(5):1310-1317. doi: 10.4103/0028-3886.271245.
42 Functions of intronic nucleotide variants in the gene encoding pleckstrin homology like domain beta 2 (PHLDB2) on susceptibility to vascular dementia.World J Biol Psychiatry. 2013 Apr;14(3):227-32. doi: 10.3109/15622975.2011.630407. Epub 2011 Nov 23.
43 A strong synergistic epistasis between FAM134B and TNFRSF19 on the susceptibility to vascular dementia.Psychiatr Genet. 2011 Feb;21(1):37-41. doi: 10.1097/YPG.0b013e3283413496.
44 Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.Physiol Int. 2018 Mar 1;105(1):38-52. doi: 10.1556/2060.105.2018.1.1.
45 Genetic association of the gene encoding RPGRIP1L with susceptibility to vascular dementia.Gene. 2012 May 10;499(1):160-2. doi: 10.1016/j.gene.2012.03.010. Epub 2012 Mar 8.
46 Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia.Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009.
47 Paeoniflorin improves regional cerebral blood flow and suppresses inflammatory factors in the hippocampus of rats with vascular dementia.Chin J Integr Med. 2017 Sep;23(9):696-702. doi: 10.1007/s11655-015-2124-3. Epub 2015 Nov 17.
48 Protective Effect of 17-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia.Sci Rep. 2017 Feb 16;7:42660. doi: 10.1038/srep42660.
49 miR?34?p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model.Int J Mol Med. 2019 Nov;44(5):1729-1740. doi: 10.3892/ijmm.2019.4331. Epub 2019 Sep 5.
50 Gastrin-releasing peptide facilitates glutamatergic transmission in the hippocampus and effectively prevents vascular dementia induced cognitive and synaptic plasticity deficits.Exp Neurol. 2017 Jan;287(Pt 1):75-83. doi: 10.1016/j.expneurol.2016.08.008. Epub 2016 Aug 15.
51 Genome-wide association study of vascular dementia.Stroke. 2012 Feb;43(2):315-9. doi: 10.1161/STROKEAHA.111.628768. Epub 2011 Nov 23.