Details of Disease

Disease Name

Clear cell adenocarcinoma

mesonephroma, malignant (morphologic abnormality); mesonephroid clear cell adenocarcinoma; Wolffian duct neoplasm; water-clear cell carcinoma; mesonephroma, malignant; mesonephroid clear cell carcinoma; clear cell carcinoma; malignant mesonephroma; clear cell adenocarcinoma NOS (morphologic abnormality); water-clear cell adenocarcinoma (morphologic abnormality); adenocarcinoma, clear cell, malignant; water-clear cell adenocarcinoma; mesonephroma NOS (morphologic abnormality); clear cell adenocarcinoma; clear cell adenocarcinoma (morphologic abnormality)

Definition

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Disease Hierarchy

DIS3IHTY: Adenocarcinoma

DISYUGHZ: Clear cell adenocarcinoma

Disease Identifiers

MONDO ID

MONDO_0005004

MESH ID

D018262

UMLS CUI

C0206681

MedGen ID

64629

SNOMED CT ID

30546008

General Information of Disease (ID: DISYUGHZ)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
INHBA	TTVB30D	Limited	Biomarker	[1]
KDM5C	TT94UCF	Limited	Biomarker	[2]
NRG4	TTWAGKJ	Limited	Biomarker	[3]
CTH	TTLQUZS	moderate	Biomarker	[4]
SLC22A16	TTITAVR	moderate	Altered Expression	[5]
GPC3	TTJTSX4	Strong	Biomarker	[6]
MMP16	TTNP4CU	Strong	Altered Expression	[7]
MUC17	TTVO0JU	Strong	Altered Expression	[8]
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⏷ Show the Full List of 8 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A11	DTEOAND	Definitive	Biomarker	[9]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
HAGH	DE05IKP	moderate	Altered Expression	[10]
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This Disease Is Related to 25 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABCF2	OTXIBZ3N	Limited	Biomarker	[11]
ANXA4	OTUCRYXL	Limited	Altered Expression	[12]
APPBP2	OTLNFV4J	Limited	Altered Expression	[13]
ARID1A	OTRWDV3P	Limited	Altered Expression	[14]
BARD1	OTTC0Z9Y	Limited	Altered Expression	[15]
C12orf75	OTFVI3EY	Limited	Biomarker	[16]
CCNB2	OTIEXTDK	Limited	Altered Expression	[17]
CCNY	OTK1KG5W	Limited	Biomarker	[3]
EMG1	OTFDX7HY	Limited	Biomarker	[18]
GNAI2	OTTLGRGH	Limited	Biomarker	[19]
KIF20A	OTXOQHE0	Limited	Altered Expression	[20]
LIMS1	OT729S0T	Limited	Altered Expression	[21]
MAML2	OT1TSVAR	Limited	Biomarker	[22]
NEU3	OTQ5PQOW	Limited	Altered Expression	[23]
ATF1	OT251CI0	moderate	Biomarker	[24]
CCDC54	OTW5WCX9	Strong	Altered Expression	[25]
EWSR1	OT7SRHV3	Strong	Genetic Variation	[26]
FLCN	OTVM78XM	Strong	Biomarker	[27]
MUC3A	OTI4XUDY	Strong	Altered Expression	[8]
NAPSA	OT6F8IAL	Strong	Biomarker	[28]
POU6F1	OTGSP4XJ	Strong	Altered Expression	[29]
REXO1	OTZT6RAW	Strong	Altered Expression	[30]
SPA17	OT8J7T7U	Strong	Altered Expression	[25]
SERPINA7	OTUYVTSU	Definitive	Biomarker	[9]
SLC25A45	OTP7EAUM	Definitive	Biomarker	[9]
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⏷ Show the Full List of 25 DOT(s)

References

1	The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells.Oncol Rep. 2006 Aug;16(2):373-9.
2	Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.Nature. 2011 Jan 27;469(7331):539-42. doi: 10.1038/nature09639. Epub 2011 Jan 19.
3	Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas.Int J Cancer. 2018 Sep 15;143(6):1379-1387. doi: 10.1002/ijc.31418. Epub 2018 Apr 25.
4	Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?.J Pathol. 2017 Sep;243(1):26-36. doi: 10.1002/path.4934. Epub 2017 Aug 7.
5	Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.Int J Gynecol Pathol. 2007 Jul;26(3):334-40. doi: 10.1097/01.pgp.0000236951.33914.1b.
6	Comparative Use of Napsin A and Glypican 3 to Distinguish Endometrial Clear Cell from Serous and Endometrioid Carcinomas.Int J Gynecol Cancer. 2018 Sep;28(7):1318-1324. doi: 10.1097/IGC.0000000000001303.
7	Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomas.J Urol. 1999 Sep;162(3 Pt 1):905-9. doi: 10.1097/00005392-199909010-00088.
8	Expression of human mucin genes in normal kidney and renal cell carcinoma.Histopathology. 2002 May;40(5):450-7. doi: 10.1046/j.1365-2559.2002.01408.x.
9	Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.PLoS One. 2015 Jun 19;10(6):e0128106. doi: 10.1371/journal.pone.0128106. eCollection 2015.
10	Overexpression of glyoxalase system enzymes in human kidney tumor.Cancer J. 2006 May-Jun;12(3):222-8. doi: 10.1097/00130404-200605000-00011.
11	Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs.Hum Pathol. 2007 Jan;38(1):134-9. doi: 10.1016/j.humpath.2006.06.026. Epub 2006 Sep 25.
12	Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin.Int J Cancer. 2009 Nov 15;125(10):2316-22. doi: 10.1002/ijc.24587.
13	Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.Clin Cancer Res. 2003 Jun;9(6):1995-2004.
14	CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis.Mod Pathol. 2017 Feb;30(2):297-303. doi: 10.1038/modpathol.2016.160. Epub 2016 Oct 21.
15	Oncogenic BARD1 isoforms expressed in gynecological cancers.Cancer Res. 2007 Dec 15;67(24):11876-85. doi: 10.1158/0008-5472.CAN-07-2370.
16	Establishment and characterization of a new human cell line derived from ovarian clear cell carcinoma.Gynecol Oncol. 1990 Jul;38(1):37-45. doi: 10.1016/0090-8258(90)90008-9.
17	Transcriptomic Characterization of Endometrioid, Clear Cell, and High-Grade Serous Epithelial Ovarian Carcinoma.Cancer Epidemiol Biomarkers Prev. 2018 Sep;27(9):1101-1109. doi: 10.1158/1055-9965.EPI-17-0728. Epub 2018 Jul 2.
18	Correlation between pre-operative and final histological diagnosis on endometrial cancer.Int J Gynecol Cancer. 2019 Jun;29(5):886-889. doi: 10.1136/ijgc-2018-000041. Epub 2019 Jan 4.
19	Suppression of GNAI2 message in ovarian cancer.J Ovarian Res. 2014 Jan 14;7:6. doi: 10.1186/1757-2215-7-6.
20	KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clearcell carcinoma cells.Oncol Rep. 2018 Jul;40(1):195-205. doi: 10.3892/or.2018.6401. Epub 2018 Apr 25.
21	Galectin 9 and PINCH, novel immunotherapy targets of renal cell carcinoma: a rationale to find potential tumour antigens and the resulting cytotoxic T lymphocytes induced by the derived peptides.BJU Int. 2014 Feb;113(2):320-32. doi: 10.1111/bju.12499.
22	Reevaluation of MAML2 fusion-negative mucoepidermoid carcinoma: a subgroup being actually hyalinizing clear cell carcinoma of the salivary gland with EWSR1 translocation.Hum Pathol. 2017 Mar;61:9-18. doi: 10.1016/j.humpath.2016.06.029. Epub 2016 Oct 18.
23	Expression of NEU3 (plasma membrane-associated sialidase) in clear cell adenocarcinoma of the ovary: its relationship with T factor of pTNM classification.Oncol Res. 2006;16(6):289-97. doi: 10.3727/000000006783981035.
24	Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas.Mod Pathol. 2018 Jun;31(6):923-933. doi: 10.1038/s41379-018-0025-7. Epub 2018 Feb 12.
25	Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study.BMC Cancer. 2018 Oct 11;18(1):970. doi: 10.1186/s12885-018-4880-x.
26	Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity.Pathobiology. 2018;85(1-2):85-95. doi: 10.1159/000479070. Epub 2017 Sep 21.
27	Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy.PLoS One. 2013 Jul 29;8(7):e70030. doi: 10.1371/journal.pone.0070030. Print 2013.
28	Napsin A and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma.APMIS. 2018 Jan;126(1):45-55. doi: 10.1111/apm.12784. Epub 2017 Nov 20.
29	POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.Hum Cell. 2009 Nov;22(4):94-100. doi: 10.1111/j.1749-0774.2009.00074.x.
30	Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma.Carcinogenesis. 2006 Mar;27(3):499-507. doi: 10.1093/carcin/bgi299. Epub 2005 Dec 12.