Details of the Drug Combination

General Information of Drug Combination (ID: DCEW6R5)

Drug Combination Name
Vandetanib Dactinomycin
Indication
Disease Entry Status REF
Malignant melanoma Investigative [1]
Component Drugs Vandetanib   DMRICNP Dactinomycin   DM2YGNW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: UACC62
Zero Interaction Potency (ZIP) Score: 12.57
Bliss Independence Score: 17.68
Loewe Additivity Score: 17.89
LHighest Single Agent (HSA) Score: 17.82

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Vandetanib
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [2]
Vandetanib Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [5]
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Inhibitor [5]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [5]
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Vandetanib Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [7]
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Vandetanib Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
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Vandetanib Interacts with 34 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Phosphorylation [9]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Increases Expression [10]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [10]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [10]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Increases Expression [10]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Activity [11]
Phosphoglycerate kinase 1 (PGK1) OT6V1ICH PGK1_HUMAN Increases Expression [10]
Calbindin (CALB1) OTM7IXDG CALB1_HUMAN Increases Expression [10]
Prothymosin alpha (PTMA) OT2W4T1M PTMA_HUMAN Decreases Expression [10]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Increases Expression [10]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [10]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [10]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [10]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Increases Expression [10]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Increases Expression [10]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [10]
DNA mismatch repair protein Msh3 (MSH3) OTD3YPVL MSH3_HUMAN Decreases Expression [10]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [12]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [10]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [13]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [10]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [13]
Collagen alpha-3(IV) chain (COL4A3) OT6SB8X5 CO4A3_HUMAN Increases Expression [10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Expression [14]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Phosphorylation [13]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Increases Expression [10]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [10]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [10]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [10]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [15]
Lysine-specific demethylase 3A (KDM3A) OTZYJ8VN KDM3A_HUMAN Increases Expression [10]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Increases Expression [10]
Insulin-induced gene 2 protein (INSIG2) OTX4VY51 INSI2_HUMAN Increases Expression [10]
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⏷ Show the Full List of 34 DOT(s)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [3]
Advanced cancer 2A00-2F9Z Approved [3]
Beckwith-Wiedemann syndrome N.A. Approved [3]
Childhood kidney Wilms tumor N.A. Approved [3]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [3]
Hamartoma N.A. Approved [3]
Solid tumour/cancer 2A00-2F9Z Approved [4]
Wilms tumor N.A. Approved [3]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [19]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [20]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [21]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [22]
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Dactinomycin Interacts with 85 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [23]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [24]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [16]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [16]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [16]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [16]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [16]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [16]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [16]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [16]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [16]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [16]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [16]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [16]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [16]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [16]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [16]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [16]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [16]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [16]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [16]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [16]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [16]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [16]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [16]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [16]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [16]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [16]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [16]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [16]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [16]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [16]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [16]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [16]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [16]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [16]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [16]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [16]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [16]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [25]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [26]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [27]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [28]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [29]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [30]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [29]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [31]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [32]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [33]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [29]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [34]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [35]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [33]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [29]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [36]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [37]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [38]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [39]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [40]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [41]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [30]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [29]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [29]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [29]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [42]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [43]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [44]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [29]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [29]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [45]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [29]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [29]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [46]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [47]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [48]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [29]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [29]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [49]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [29]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [39]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [36]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [15]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [30]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [50]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [51]
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⏷ Show the Full List of 85 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Breast adenocarcinoma DC42VOV MDA-MB-468 Investigative [52]
Carcinoma DCX8WRY RXF 393 Investigative [52]
Carcinoma DC9YCD1 MCF7 Investigative [52]
Colon adenocarcinoma DCDMK1K COLO 205 Investigative [52]
Colon carcinoma DCKKO1A KM12 Investigative [52]
Invasive ductal carcinoma DC7CFDY T-47D Investigative [52]
Invasive ductal carcinoma DCA4334 BT-549 Investigative [52]
Adenocarcinoma DC2C93N DU-145 Investigative [1]
Adenocarcinoma DCXSMS7 OVCAR3 Investigative [1]
Adenocarcinoma DCLJRPS A549 Investigative [1]
Adenocarcinoma DC7BUP2 NCIH23 Investigative [1]
Adenocarcinoma DCP57NJ SW-620 Investigative [1]
Adenocarcinoma DCU33X4 HCC-2998 Investigative [1]
Adenocarcinoma DCSFDQO HCT116 Investigative [1]
Adenocarcinoma DCZNYIF HT29 Investigative [1]
Adult T acute lymphoblastic leukemia DCRH0XR MOLT-4 Investigative [1]
Amelanotic melanoma DCIX1VA M14 Investigative [1]
Amelanotic melanoma DC9FO52 MDA-MB-435 Investigative [1]
Anaplastic large cell lymphoma DCPGAXS SR Investigative [1]
Astrocytoma DCBCTBV U251 Investigative [1]
Astrocytoma DCK5ZH6 SNB-19 Investigative [1]
Childhood T acute lymphoblastic leukemia DCII7EL CCRF-CEM Investigative [1]
Chronic myelogenous leukemia DCLD97O K-562 Investigative [1]
Clear cell renal cell carcinoma DCNBBO0 TK-10 Investigative [1]
Clear cell renal cell carcinoma DC7OAF4 786-0 Investigative [1]
Clear cell renal cell carcinoma DC492HV A498 Investigative [1]
Clear cell renal cell carcinoma DCW8WR1 CAKI-1 Investigative [1]
Cutaneous melanoma DC33OXX SK-MEL-5 Investigative [1]
Cutaneous melanoma DC4XZU7 SK-MEL-28 Investigative [1]
Glioblastoma DCV1K6P SNB-75 Investigative [1]
Glioma DCHAKXK SF-539 Investigative [1]
Glioma DCLPHIR SF-268 Investigative [1]
Glioma DCRIP4G SF-295 Investigative [1]
High grade ovarian serous adenocarcinoma DCMOTYB OVCAR-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCR5LRK OVCAR-4 Investigative [1]
High grade ovarian serous adenocarcinoma DCZ1RI8 OVCAR-8 Investigative [1]
Large cell lung carcinoma DCGP1GM NCI-H460 Investigative [1]
Lung adenocarcinoma DCIMQWK MDA-MB-231 Investigative [1]
Lung adenocarcinoma DCEJZSL EKVX Investigative [1]
Lung adenocarcinoma DCDVA5S HOP-62 Investigative [1]
Lung adenocarcinoma DCZC3NY NCI-H522 Investigative [1]
Malignant melanoma DCY1MLK LOX IMVI Investigative [1]
Melanoma DCHUN2Z SK-MEL-2 Investigative [1]
Melanoma DCXKD7A MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DCGOXP8 NCI-H322M Investigative [1]
Mixed endometrioid and clear cell carcinoma DCDYUGG IGROV1 Investigative [1]
Non-small cell lung carcinoma DCL44UT HOP-92 Investigative [1]
Papillary renal cell carcinoma DCO68HR ACHN Investigative [1]
Plasma cell myeloma DCMEG9X RPMI-8226 Investigative [1]
Pleural epithelioid mesothelioma DCHZ4EA NCI-H226 Investigative [1]
Prostate carcinoma DCGG4WB PC-3 Investigative [1]
Renal cell carcinoma DCAOFKB SN12C Investigative [1]
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⏷ Show the Full List of 52 DrugCom(s)

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