Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM537OH)

Drug Name

Clobenpropit Drug Info

Synonyms

clobenpropit; 145231-45-4; Vuf-9153; Vuf 9153; UNII-RKU631JF4H; S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea; CHEBI:64177; RKU631JF4H; 3-(1h-imidazol-5-yl)propyl n'-(4-chlorobenzyl)carbamimidothioate; 3-(1H-imidazol-4-yl)propyl ((4-chlorophenyl)methyl)carbamimidothioate; Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester; 3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate; Carbamimidothioic acid,N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2790
ChEBI ID: CHEBI:64177
CAS Number: CAS 145231-45-4
TTD Drug ID: DM537OH

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[9]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[10]
UR-63325	DME6X27	Allergic rhinitis	CA08.0	Phase 2	[11]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[12]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[13]
impromidine	DMTDRPM	Discovery agent	N.A.	Investigative	[14]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[15]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[16]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[17]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[18]
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Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[19]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[20]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[21]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[22]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[23]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[24]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[25]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[26]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[24]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[27]
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Drug(s) Affected By Histamine H3 receptor (HRH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Irdabisant	DMR3E4L	Cognitive impairment	6D71	Phase 1	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
N-[3H]alpha-methylhistamine	DMWDCV1	Discovery agent	N.A.	Investigative	[32]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[33]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[30]
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Drug(s) Affected By Histamine H4 receptor (HRH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[36]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[37]
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Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[39]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[40]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
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Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[39]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[48]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[49]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[56]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[61]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[62]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
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Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[68]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[69]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[70]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[71]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Antagonist	[2]
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Agonist	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[4]
Histamine H3 receptor (HRH3)	OT7GF3AI	HRH3_HUMAN	Protein Interaction/Cellular Processes	[5]
Histamine H4 receptor (HRH4)	OTBJO49O	HRH4_HUMAN	Drug Response	[6]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Gene/Protein Processing	[7]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Gene/Protein Processing	[7]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Gene/Protein Processing	[8]

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