Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6K7BI)

• Drug Name: 3-Ethoxy-9H-beta-carboline Drug Info
• Synonyms: 3-Ethoxy-beta-carboline; 3-ethoxy-9H-pyrido[3,4-b]indole; CHEMBL498936; CHEMBL299250; 3-ethoxy-9h-; AC1Q4YMX; AC1L3YI4; SCHEMBL9531510; FNNPSIGQQWCKKB-UHFFFAOYSA-N; ZINC5139892; BDBM50001475; PDSP2_001734; BDBM50244034; PDSP1_001751; 3-Ethoxy-9H-beta-carboline(3-EBC); 9H-Pyrido(3,4-b)indole, 3-ethoxy-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 124477
  CAS Number: CAS 91985-81-8
  TTD Drug ID: DM6K7BI

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[4]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[5]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[6]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[5]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[4]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[7]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[8]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[9]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[10]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting GABA(A) receptor alpha-5 (GABRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[12]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[13]
Basmisanil	DMQ8J0U	Alzheimer disease	8A20	Phase 2	[14]
RG-7816	DMD16JK	Autism spectrum disorder	6A02	Phase 1	[15]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[12]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[11]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[16]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[12]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[17]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[12]

Drug(s) Targeting GABA(A) receptor alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[18]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[13]
PF-4480682	DMWYJHC	Neuropathic pain	8E43.0	Discontinued in Phase 2	[19]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[9]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[18]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[11]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[16]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[18]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[17]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[18]

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[20]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[21]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[20]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[20]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[4]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[20]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[20]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[5]
Meprobamate	DMHM93Y	Anxiety		Approved	[20]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[22]

Drug(s) Targeting GABA(A) receptor alpha-3 (GABRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[23]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[13]
Adipiplon	DM821BS	Sleep-wake disorder	7A00-7B2Z	Phase 2	[24]
NS-2710	DMMUR6V	Anxiety disorder	6B00-6B0Z	Phase 2	[25]
AZD6280	DMFAZLU	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[26]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[23]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[11]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[16]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[23]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[20]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[27]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[5]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[28]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[29]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[30]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[31]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[32]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[27]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Inhibitor	[2]
GABA(A) receptor alpha-2 (GABRA2)	TTBMV1G	GBRA2_HUMAN	Inhibitor	[1]
GABA(A) receptor alpha-3 (GABRA3)	TT37EDJ	GBRA3_HUMAN	Inhibitor	[3]
GABA(A) receptor alpha-5 (GABRA5)	TTNZPQ1	GBRA5_HUMAN	Inhibitor	[3]
GABA(A) receptor gamma-2 (GABRG2)	TT06RH5	GBRG2_HUMAN	Inhibitor	[1]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[1]

References

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