Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC471Z)

• Drug Name: RHC80267 Drug Info
• Synonyms: RHC 80267; U 57908; RHC-80267

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5063
  ChEBI ID: CHEBI:92984
  CAS Number: CAS 83654-05-1
  TTD Drug ID: DMC471Z

Molecule-Related Drug Atlas

Drug(s) Targeting Diacylglycerol lipase alpha (DAGLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29053063-Compound-15	DM07U5R	N. A.	N. A.	Patented	[5]

Drug(s) Affected By Fatty-acid amide hydrolase 1 (FAAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[6]
Selenium	DM25CGV	N. A.	N. A.	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[13]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
ASP-8477	DMBZQS7	Neuropathic pain	8E43.0	Phase 2	[15]

Drug(s) Affected By Phosphatidylserine lipase ABHD16A (ABHD16A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[18]
Bortezomib	DMNO38U	Leukemia		Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[23]

Drug(s) Affected By Platelet-activating factor acetylhydrolase (PLA2G7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[28]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[29]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[28]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol lipase alpha (DAGLA)	TTRQ6UD	DGLA_HUMAN	Inhibitor	[2]
Diacylglycerol lipase beta (DAGLB)	TTXZDEN	DGLB_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Fatty-acid amide hydrolase 1 (FAAH)	OT9DX3N1	FAAH1_HUMAN	Gene/Protein Processing	[4]
Phosphatidylserine lipase ABHD16A (ABHD16A)	OTDS9K1Z	ABHGA_HUMAN	Gene/Protein Processing	[4]
Platelet-activating factor acetylhydrolase (PLA2G7)	OT6H6AMO	PAFA_HUMAN	Gene/Protein Processing	[4]

References

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