Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME0XHN)

• Drug Name: [3H]folinic acid Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135403648
  ChEBI ID: CHEBI:15640
  CAS Number: CAS 58-05-9
  TTD Drug ID: DME0XHN
  ACDINA Drug ID: D00357

Molecule-Related Drug Atlas

Drug(s) Targeting Proton-coupled folate transporter (SLC46A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[2]
PREMETREXED	DMVOGT4	Discovery agent	N.A.	Investigative	[2]
[3H]N5-methylfolate	DM0THB9	Discovery agent	N.A.	Investigative	[2]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[23]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[11]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[12]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[14]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[26]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[27]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[28]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[28]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[4]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[29]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[30]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[31]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[31]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[31]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[33]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[31]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proton-coupled folate transporter (SLC46A1)	TTY8Z2E	PCFT_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Gene/Protein Processing	[3]
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Regulation of Drug Effects	[4]
Proton-coupled folate transporter (SLC46A1)	OT049V7Y	PCFT_HUMAN	Gene/Protein Processing	[5]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Regulation of Drug Effects	[4]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213).
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