Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME1AGO)

Drug Name

5-Fluoro-2'-Deoxyuridine-5'-Monophosphate Drug Info

Synonyms

5-fluorodeoxyuridine monophosphate; FLUORODEOXYURIDYLATE; 5-fluoro-2'-deoxyuridine-5'-monophosphate; F-dUMP; 134-46-3; FdUMP; CHEMBL886; CHEBI:2129; UNII-7CJ707H131; 7CJ707H131; 88410-68-8; 5-FLUORO-2-DEOXYURIDINE MONOPHOSPHATE (FDUMP); [(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate; UFP; Poly(dF5U); Poly(5'-FU); Poly(5-fluoro-2'-deoxyuridylic acid); 5FdUMP; DB03761; 5'-Uridylic acid, 2'-deoxy-5-fluoro-; AC1L1RES; 5'-Uridylic acid,2'-deoxy-5-fluoro-, homopolymer

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 8642
ChEBI ID: CHEBI:2129
CAS Number: CAS 134-46-3
TTD Drug ID: DME1AGO

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Candida Thymidylate synthase (Candi TMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[6]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[7]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[8]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[9]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[10]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[11]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[12]
Nolatrexed	DMOF0CA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
Plevitrexed (R)-isomer	DMTL39C	Gastric adenocarcinoma	2B72	Phase 2	[14]
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Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[3]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[24]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
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Drug(s) Affected By ATP-binding cassette sub-family C member 11 (ABCC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[40]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[41]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Thymidylate synthase (Candi TMP1)	TTU6BFZ	TYSY_CANAL	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 11 (ABCC11)	OTVHL7OR	MRP8_HUMAN	Drug Response	[2]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Regulation of Drug Effects	[3]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Regulation of Drug Effects	[4]

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References

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