Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNUKIX)

Drug Name
D-myo-inositol 1,4,5-trisphosphate Drug Info
Synonyms
d-Myo-inositol-1,4,5-triphosphate; inositol 1,4,5-trisphosphate; 1,4,5-Insp3; InsP3; d-myo-inositol-1,4,5-triphosphate; 1D-myo-Inositol 1,4,5-trisphosphate; D-myo-Inositol 1,4,5-trisphosphate; IP3; Ins(1,4,5)P3; 85166-31-0; CHEMBL279107; CHEBI:16595; Triphosphoinositol; I3P; 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate); D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate); {[(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis(phosphonooxy)cyclohexyl]oxy}phosphonic acid; D-myo-Inositol 1,4,5-triphosphate; 1btn; 1mai; Inositol trisphosphate; 1n4k; 1h0a; D-Myo-Inositol-1,4,5-Triphosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
439456
ChEBI ID
CHEBI:16595
CAS Number
CAS 85166-31-0
TTD Drug ID
DMNUKIX
INTEDE Drug ID
DR2057

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inositol 1,4,5-trisphosphate receptor (ITPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitroprusside DMLUA2J Hypertension BA00-BA04 Approved [7]
ADENOPHOSTIN A DMV39AW Discovery agent N.A. Investigative [8]
5'-Deoxy-5'-phenyladenophostin A DMU4MCK Discovery agent N.A. Investigative [8]
Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [9]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [12]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [13]
Bortezomib DMNO38U Leukemia Approved [14]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [17]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [18]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 4 (TNFSF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Leflunomide DMR8ONJ Arthritis FA20 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [27]
Menthol DMG2KW7 Back pain ME84.Z Approved [28]
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Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Epinephrine DM3KJBC Acute asthma CA23 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [32]
Terbutaline DMD4381 Asthma CA23 Approved [33]
Quinidine DMLPICK N. A. N. A. Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
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Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [36]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [29]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Epinephrine DM3KJBC Acute asthma CA23 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Quinidine DMLPICK N. A. N. A. Approved [4]
Norepinephrine DMOUC09 Alopecia ED70 Approved [39]
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Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alfuzosin DMZVMKF Benign prostatic hyperplasia GA90 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Epinephrine DM3KJBC Acute asthma CA23 Approved [29]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Terbutaline DMD4381 Asthma CA23 Approved [33]
Methoxamine DMF5XQH Hypertension BA00-BA04 Approved [40]
Quinidine DMLPICK N. A. N. A. Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Norepinephrine DMOUC09 Alopecia ED70 Approved [40]
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Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [49]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [50]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inositol 1,4,5-trisphosphate receptor (ITPR) TTC9IZL ITPR1_HUMAN; ITPR2_HUMAN; ITPR3_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Inositol polyphosphate multikinase (IPMK) Main DME DESA9EX IPMK_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Regulation of Drug Effects [3]
Alpha-1A adrenergic receptor (ADRA1A) OTUIWCL5 ADA1A_HUMAN Regulation of Drug Effects [4]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Regulation of Drug Effects [4]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Regulation of Drug Effects [4]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Biotransformations [5]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Regulation of Drug Effects [6]

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