Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR8HKC)

• Drug Name: Chebulinic acid Drug Info
• Synonyms: Chebulinic acid; 18942-26-2; UNII-HVC8VQJ6EK; HVC8VQJ6EK; AC1L2HS1; CHEMBL501154; NSC69862; NSC 69862; CHEBI:3584; ZINC195763592; FT-0697896; C10215; Q-100932; beta-D-Glucopyranose, cyclic 2,4-ester with 3-(6-carboxy-2,3,4-trihydroxyphenyl)-4-hydroxy-1,2,4-butanetricarboxylic acid, 1,3,6-tris(3,4,5-trihydroxybenzoate)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 72284
  ChEBI ID: CHEBI:3584
  TTD Drug ID: DMR8HKC

Molecule-Related Drug Atlas

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[3]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[4]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[5]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[4]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[6]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[1]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[1]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Porphobilinogen deaminase (HMBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[10]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[11]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[12]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[16]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[12]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[23]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[24]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[25]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[26]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[27]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[28]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[31]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[32]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[10]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[2]
Endothelial transcription factor GATA-2 (GATA2)	OTBP2QQ2	GATA2_HUMAN	Gene/Protein Processing	[2]
Erythroid transcription factor (GATA1)	OTX1R7O1	GATA1_HUMAN	Gene/Protein Processing	[2]
Porphobilinogen deaminase (HMBS)	OT3P47DC	HEM3_HUMAN	Gene/Protein Processing	[2]
Transcription factor NF-E2 45 kDa subunit (NFE2)	OTLM94BI	NFE2_HUMAN	Gene/Protein Processing	[2]

References

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