Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRCLZB)

Drug Name

Pentagastrin Drug Info

Synonyms

Peptavlon; Peptavlon (TN); Pentagastrin (JAN/USAN/INN); (3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Diagnostic imaging	N.A.	Approved	[1]

Therapeutic Class

Diagnostic Agents

Cross-matching ID

PubChem CID: 9853654
ChEBI ID: CHEBI:31974
CAS Number: CAS 5534-95-2
TTD Drug ID: DMRCLZB

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Gastrin/cholecystokinin type B receptor (CCKBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[6]
GASTRAZOLE	DMO3ITF	Duodenal ulcer	DA63	Phase 3	[7]
Dexloxiglumide	DM52HUD	Pancreatic malfunction	DC30-DC3Z	Phase 2	[8]
Spiroglumide	DM7NJWY	Stomach disease	DA43-DA4Y	Phase 2	[9]
TT-223	DMCDMFP	Type-1 diabetes	5A10	Phase 2	[10]
Z 360	DM2M80G	Discovery agent	N.A.	Phase 2	[11]
S-0509	DM4KWEF	Ulcerative colitis	DD71	Phase 2	[12]
YF-476	DM54MAJ	Stomach ulcer	DA60.Z	Phase 2	[13]
Itriglumide	DM5UFRO	Anxiety disorder	6B00-6B0Z	Phase 2	[14]
Demogastrin	DMTULGS	Thyroid cancer	2D10	Phase 1	[15]
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Drug(s) Affected By Pro-opiomelanocortin (POMC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[16]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[17]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[18]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[20]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[21]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[22]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[25]
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Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Fructose	DM43AN2	Vomiting	MD90	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[32]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[33]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
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Drug(s) Affected By Secretin (SCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[42]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[43]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[44]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[44]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastrin/cholecystokinin type B receptor (CCKBR)	TTVFO0U	GASR_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Insulin (INS)	OTZ85PDU	INS_HUMAN	Protein Interaction/Cellular Processes	[3]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Gene/Protein Processing	[4]
Secretin (SCT)	OTV3MLOO	SECR_HUMAN	Drug Response	[5]

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References

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35	Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res. 1998 Oct;30(10):642-5. doi: 10.1055/s-2007-978950.
36	Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. Ann N Y Acad Sci. 2006 Jul;1070:393-8. doi: 10.1196/annals.1317.051.
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38	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
39	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
40	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
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42	Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
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