Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSJLWP)

Drug Name

Ro 41-5253 Drug Info

Synonyms

Ro-415253; Ro415253; LG629

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5312120
ChEBI ID: CHEBI:90706
CAS Number: CAS 144092-31-9
TTD Drug ID: DMSJLWP

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[7]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[9]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[10]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[10]
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[11]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[12]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[13]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[14]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[15]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[19]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[22]
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Drug(s) Affected By Beta,beta-carotene 15,15'-dioxygenase (BCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[28]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[29]
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Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[32]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
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Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
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Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[48]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[52]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Antagonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beta,beta-carotene 15,15'-dioxygenase (BCO1)	OTZKQTCL	BCDO1_HUMAN	Gene/Protein Processing	[3]
Hepatic sodium/bile acid cotransporter (SLC10A1)	OTUJVMCL	NTCP_HUMAN	Gene/Protein Processing	[4]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Protein Interaction/Cellular Processes	[5]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Drug Response	[4]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Gene/Protein Processing	[6]

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References

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