Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUELHN)

• Drug Name: Thiourea Drug Info
• Synonyms: 2-Thiopseudourea; 2-Thiourea; Carbamimidothioic acid; Caswell No. 855; Isothiourea; Pseudothiourea; Pseudourea, 2-thio-; RCRA waste no. U219;.beta.-Thiopseudourea; RCRA waste number U219; Sulfourea; Sulfouren; Sulourea; THIOUREA; Thiocarbamid; Thiocarbamide; Thiocarbonic acid diamide; Thioharnstoff; Thiokarbamid; Thiomocovina; Thiomocovina [Czech]; Thiurea; Thiuronium; Tsizp 34; Urea, 2-thio-; Urea, thio-; beta-Thiopseudourea; carbonothioic diamide; sulfocarbamide; thio-urea
• Cross-matching ID:
  PubChem CID: 2723790
  ChEBI ID: CHEMBL260876
  CAS Number: CAS 62-56-6
  TTD Drug ID: DMUELHN
  VARIDT Drug ID: DR00349

Molecule-Related Drug Atlas

Drug(s) Transported By Urea transporter 1 (SLC14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
methylurea	DMAEQB6	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[6]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[8]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[9]
Almogran	DM7I64Z	Migraine	8A80	Approved	[10]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[11]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[13]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[14]

Drug(s) Affected By Flavin-containing monooxygenase 2 (FMO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[15]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[15]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[5]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[6]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Urea transporter 1 (SLC14A1)	DTMF8LB	UT1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Flavin-containing monooxygenase 2 (FMO2)	OTUJUL9S	FMO2_HUMAN	Regulation of Drug Effects	[2]
Flavin-containing monooxygenase 3 (FMO3)	OT1G2EV3	FMO3_HUMAN	Drug Response	[3]

References

• [1] Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8.
• [2] Genetic polymorphisms of flavin-containing monooxygenase (FMO). Drug Metab Rev. 2002 Aug;34(3):523-32. doi: 10.1081/dmr-120005653.
• [3] Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. Biochem Pharmacol. 2002 Jun 1;63(11):1941-8. doi: 10.1016/s0006-2952(02)00978-4.
• [4] Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta. 2007 Jul;1768(7):1815-21.
• [5] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [6] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [7] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [8] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [9] Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20.
• [10] Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
• [11] Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos. 2004 Nov;32(11):1247-53. doi: 10.1124/dmd.104.000026. Epub 2004 Jul 30.
• [12] Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther. 2007 Jan;320(1):266-73. doi: 10.1124/jpet.106.112268. Epub 2006 Oct 18.
• [13] Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis. Clin Cancer Res. 2004 Dec 15;10(24):8357-62. doi: 10.1158/1078-0432.CCR-04-1073.
• [14] Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries. OMICS. 2013 Jul;17(7):353-67. doi: 10.1089/omi.2013.0019. Epub 2013 Jun 11.
• [15] Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82.
• [16] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [17] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [18] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [19] Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenet Genomics. 2005 Apr;15(4):245-56. doi: 10.1097/01213011-200504000-00008.
• [20] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.