Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVYRH2)

Drug Name

Perifosine Drug Info

Synonyms

D 21266; NKA17; D-21266; KRX-0401; KRX-0401, NSC 639966; Octadecyl-(1,1-dimethyl-4-piperidylio)phosphate; Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt; Piperidinium, 4-((hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethyl-, inner salt; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate; 4-((Hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethylpiperidinium inner salt

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 148177
ChEBI ID: CHEBI:67272
CAS Number: CAS 157716-52-4
TTD Drug ID: DMVYRH2

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[7]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[8]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[9]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[10]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[11]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[10]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[12]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[13]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[13]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[14]
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Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[15]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[16]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Ketoprofen	DMRKXPT	Bursitis		Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[19]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[21]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[29]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[28]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Fructose	DM43AN2	Vomiting	MD90	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[41]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[49]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[50]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[53]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[54]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[60]
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Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
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Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[75]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[76]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[3]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[4]
Linker for activation of T-cells family member 2 (LAT2)	OTWJDKIH	NTAL_HUMAN	Drug Response	[5]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[4]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[6]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Protein Interaction/Cellular Processes	[6]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Protein Interaction/Cellular Processes	[6]

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References

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2	Company report (Aezsinc)
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