Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ43OM)

• Drug Name: PMID26560530-Compound-25 Drug Info
• Cross-matching ID:
  PubChem CID: 2194
  ChEBI ID: CHEBI:31221
  CAS Number: CAS 532-11-6
  TTD Drug ID: DMZ43OM

Molecule-Related Drug Atlas

Drug(s) Targeting Tissue transglutaminase (TG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZED1227	DMDXEN5	Coeliac disease	DA95	Phase 2	[5]
PMID26560530-Compound-13	DMKF26Z	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-54	DM2X4R0	N. A.	N. A.	Patented	[1]
Triazole derivative 1	DM9QB2S	N. A.	N. A.	Patented	[1]
Acyl piperidine derivative 3	DMIDUB4	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-14	DM52MIK	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-1	DMSI7F2	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-3	DM92OT0	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-11	DMZ5UST	N. A.	N. A.	Patented	[1]
Chloroacetyl ester derivative 1	DMW4J0P	N. A.	N. A.	Patented	[1]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Ketoprofen	DMRKXPT	Bursitis		Approved	[7]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Haloperidol	DM96SE0	Delirium		Approved	[7]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]

Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[24]
Fructose	DM43AN2	Vomiting	MD90	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[29]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[24]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[32]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[34]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[24]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[38]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[39]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[48]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tissue transglutaminase (TG2)	TT2F4OL	TGM2_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Gene/Protein Processing	[2]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[3]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Gene/Protein Processing	[3]
Glutathione synthetase (GSS)	OTVSBEIW	GSHB_HUMAN	Gene/Protein Processing	[4]
Protachykinin-1 (TAC1)	OTM842YW	TKN1_HUMAN	Gene/Protein Processing	[2]

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