Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZC1HS)

• Drug Name: Ivacaftor Drug Info
• Synonyms: Kalydeco (TN)

Indication

Disease Entry	ICD 11	Status	REF
Cystic fibrosis	CA25	Approved	[1]

• Cross-matching ID:
  PubChem CID: 16220172
  ChEBI ID: CHEBI:66901
  CAS Number: CAS 873054-44-5
  TTD Drug ID: DMZC1HS
  VARIDT Drug ID: DR00466
  INTEDE Drug ID: DR0898
  ACDINA Drug ID: D00339

Molecule-Related Drug Atlas

Drug(s) Targeting cAMP-dependent chloride channel (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[6]
Tezacaftor and ivacaftor	DMY62FC	Acute lung injury	NB32.3	Approved	[7]
VX-661	DMJBXO3	Cystic fibrosis	CA25	Phase 3	[8]
ABBV-2222	DM4ZLTY	Cystic fibrosis	CA25	Phase 2	[9]
GLPG-1837	DMOCRYB	Cystic fibrosis	CA25	Phase 2	[9]
iOWH032	DM5TMYC	Diarrhea	ME05.1	Phase 2	[10]
Lumacaftor	DMCLWDJ	Cystic fibrosis	CA25	Phase 2	[11]
QBW251	DMQ5APT	Chronic obstructive pulmonary disease	CA22	Phase 2	[12]
ABBV-3067	DMB01L5	Cystic fibrosis	CA25	Phase 1	[9]
ABBV-2737	DMU6K37	Cystic fibrosis	CA25	Phase 1	[9]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[13]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[32]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[41]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[42]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[39]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[43]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[45]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
cAMP-dependent chloride channel (CFTR)	TTRLZHP	CFTR_HUMAN	Modulator	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Gene/Protein Processing	[5]

References

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