Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHQPL7)

• DTT Name: Carbonic anhydrase I (CA-I) DTT Info
• UniProt ID: CAH1_HUMAN
• Gene Name: CA1

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Glaucoma/ocular hypertension	9C61	Approved	[1]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[1]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[1]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[2]
Salicyclic acid	DM2F8XZ	Seborrhoeic dermatitis	EA81	Approved	[3]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[4]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[6]
Phenol	DM1QSM3	N. A.	N. A.	Phase 2/3	[5]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[8]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ferulic Acid	DMJC7NF	Discovery agent	N.A.	Patented	[6]

178 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2-bromophenyl)difluoromethanesulfonamide	DMFX9H8	Discovery agent	N.A.	Investigative	[9]
(4-bromophenyl)difluoromethanesulfonamide	DMOCYZJ	Discovery agent	N.A.	Investigative	[9]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide	DMNHGVD	Discovery agent	N.A.	Investigative	[10]
1-acetamido-5-sulfonamidoindane	DM92ZCU	Discovery agent	N.A.	Investigative	[11]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide	DMUXSH5	Discovery agent	N.A.	Investigative	[10]
1-cyclohexylamido-5-sulfonamidoindane	DMFPQME	Discovery agent	N.A.	Investigative	[12]
1-pentafluorophenylamido-5-sulfonamidoindane	DM9PNTQ	Discovery agent	N.A.	Investigative	[12]
1-valproylamido-5-sulfonamidoindane	DM9ZRU2	Discovery agent	N.A.	Investigative	[12]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide	DMG4ITB	Discovery agent	N.A.	Investigative	[13]
2,3-dihydro-1H-indene-5-sulfonamide	DM46MKY	Discovery agent	N.A.	Investigative	[11]
2,4-dichloro-5-sulfamoylbenzoic acid	DM4EY5S	Discovery agent	N.A.	Investigative	[14]
2,4-Disulfamyltrifluoromethylaniline	DM2AW0Z	Discovery agent	N.A.	Investigative	[15]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide	DM1JKWL	Discovery agent	N.A.	Investigative	[16]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide	DMFGQ7K	Discovery agent	N.A.	Investigative	[16]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide	DMRADWB	Discovery agent	N.A.	Investigative	[16]
2-(biphenyl-4-yl)vinylboronic acid	DMRQOKB	Discovery agent	N.A.	Investigative	[17]
2-acetamido-5-sulfonamidoindane	DMPKBVR	Discovery agent	N.A.	Investigative	[12]
2-Acetylamino-indan-5-sulfonic acid hydrate	DMEQKIU	Discovery agent	N.A.	Investigative	[11]
2-Amino-indan-5-sulfonic acid	DMCUSH1	Discovery agent	N.A.	Investigative	[11]
2-butylamido-5-sulfonamidoindane	DML9MCU	Discovery agent	N.A.	Investigative	[12]
2-cyclohexylamido-5-sulfonamidoindane	DMFBD3K	Discovery agent	N.A.	Investigative	[12]
2-ethylamido-5-sulfonamidoindane	DMDY3JQ	Discovery agent	N.A.	Investigative	[12]
2-Hydroxycinnamic acid	DM86HTZ	Discovery agent	N.A.	Investigative	[5]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide	DMXEUDM	Discovery agent	N.A.	Investigative	[18]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide	DMDTRZ2	Discovery agent	N.A.	Investigative	[19]
2-nonylamido-5-sulfonamidoindane	DMOGWIK	Discovery agent	N.A.	Investigative	[12]
2-oxo-2H-chromene-3-carboxylic acid	DMFN769	Discovery agent	N.A.	Investigative	[20]
2-oxo-2H-thiochromene-3-carboxylic acid	DMZTCOM	Discovery agent	N.A.	Investigative	[20]
2-pentafluorophenylamido-5-sulfonamidoindane	DMZ9NCA	Discovery agent	N.A.	Investigative	[12]
2-propylamido-5-sulfonamidoindane	DMG0I25	Discovery agent	N.A.	Investigative	[12]
2-valproylamido-5-sulfonamidoindane	DM8XSE3	Discovery agent	N.A.	Investigative	[12]
3-(3-Phenyl-ureido)-benzenesulfonamide	DM314ZE	Discovery agent	N.A.	Investigative	[13]
3-(4-sulfamoylphenyl)propanoic acid	DMBDW8P	Discovery agent	N.A.	Investigative	[21], [15]
3-bromophenyl-difluoromethanesulfonamide	DMXZW3R	Discovery agent	N.A.	Investigative	[9]
3-Chloro-4-hydrazino-benzenesulfonamide	DMSB5IQ	Discovery agent	N.A.	Investigative	[22]
3-Fluoro-4-hydrazino-benzenesulfonamide	DMLG69R	Discovery agent	N.A.	Investigative	[22]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide	DMQ09J8	Discovery agent	N.A.	Investigative	[23]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide	DM43CIK	Discovery agent	N.A.	Investigative	[24]
3-phenylprop-1-enylboronic acid	DMIJN9E	Discovery agent	N.A.	Investigative	[17]
4,4'-thiodipyridine-3-sulfonamide	DM0K5JM	Discovery agent	N.A.	Investigative	[25]
4,6-Dinitro salicylic acid	DMIJ4VZ	Discovery agent	N.A.	Investigative	[26]
4-(2-AMINOETHYL)BENZENESULFONAMIDE	DMEK6WX	Discovery agent	N.A.	Investigative	[27]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide	DMWG706	Discovery agent	N.A.	Investigative	[15]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide	DME6DHX	Discovery agent	N.A.	Investigative	[25]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide	DMZ62L3	Discovery agent	N.A.	Investigative	[28]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide	DM9GOTA	Discovery agent	N.A.	Investigative	[28]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide	DMCOD4N	Discovery agent	N.A.	Investigative	[28]
4-(2-Phenylacetamido)benzenesulfonamide	DMFYR6H	Discovery agent	N.A.	Investigative	[28]
4-(2-Phenylacetamidoethyl)benzenesulfonamide	DM1JL03	Discovery agent	N.A.	Investigative	[28]
4-(2-Phenylacetamidomethyl)benzenesulfonamide	DMDYHXE	Discovery agent	N.A.	Investigative	[28]
4-(2-Propynylthio)pyridine-3-sulfonamide	DMT9RAC	Discovery agent	N.A.	Investigative	[25]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide	DM9LKMP	Discovery agent	N.A.	Investigative	[28]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide	DMD6AYQ	Discovery agent	N.A.	Investigative	[28]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide	DMNEAJH	Discovery agent	N.A.	Investigative	[25]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide	DMRJLAP	Discovery agent	N.A.	Investigative	[25]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide	DMKT20Q	Discovery agent	N.A.	Investigative	[25]
4-(Allylamino)-3-pyridinesulfonamide	DM6MQCI	Discovery agent	N.A.	Investigative	[25]
4-(Carbamolymethylthio)pyridine-3-sulfonamide	DM12R4M	Discovery agent	N.A.	Investigative	[25]
4-(Cyanomethylthio)pyridine-3-sulfonamide	DMZP20H	Discovery agent	N.A.	Investigative	[25]
4-(hydroxymethyl)benzenesulfonamide	DMR6VWL	Discovery agent	N.A.	Investigative	[15]
4-(Methylhydrazino)-3-pyridinesulfonamide	DM4BPL1	Discovery agent	N.A.	Investigative	[25]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide	DMYCV8E	Discovery agent	N.A.	Investigative	[25]
4-(Quinolinoxy)-3-pyridinesulfonamide	DMPNXFA	Discovery agent	N.A.	Investigative	[25]
4-Amino-3-bromo-benzenesulfonamide	DMVUCZK	Discovery agent	N.A.	Investigative	[15]
4-Amino-3-chloro-benzenesulfonamide	DMERTQ4	Discovery agent	N.A.	Investigative	[15]
4-Amino-3-fluoro-benzenesulfonamide	DMIQ3VR	Discovery agent	N.A.	Investigative	[29]
4-Amino-3-iodo-benzenesulfonamide	DMCOYHR	Discovery agent	N.A.	Investigative	[15]
4-amino-6-chlorobenzene-1,3-disulfonamide	DMIWGZS	Discovery agent	N.A.	Investigative	[29]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMJZNX6	Discovery agent	N.A.	Investigative	[15]
4-azidobenzenesulfonamide	DM7EQ06	Discovery agent	N.A.	Investigative	[30]
4-Benzenesulfonylamino-benzenesulfonamide	DMC7HKA	Discovery agent	N.A.	Investigative	[13]
4-Benzythiopyridine-3-sulfonamide	DMI1EFY	Discovery agent	N.A.	Investigative	[25]
4-bromophenylboronic acid	DM2YN37	Discovery agent	N.A.	Investigative	[17]
4-butylphenylboronic acid	DMD9FZW	Discovery agent	N.A.	Investigative	[17]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide	DM2UYCS	Discovery agent	N.A.	Investigative	[11]
4-Ethoxy-3-pyridinesulfonamide	DM8WAOR	Discovery agent	N.A.	Investigative	[25]
4-ethynyl benzene sulfonamide	DMIF1D6	Discovery agent	N.A.	Investigative	[31]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMGBKN7	Discovery agent	N.A.	Investigative	[32]
4-Hydrazino-3-pyridinesulfonamide	DMSZMQU	Discovery agent	N.A.	Investigative	[25]
4-Hydrazino-benzenesulfonamide	DM49B18	Discovery agent	N.A.	Investigative	[22]
4-Hydrazinocarbonyl-benzenesulfonamide	DM8PBEJ	Discovery agent	N.A.	Investigative	[22]
4-isothiocyanatobenzenesulfonamide	DMBK67H	Discovery agent	N.A.	Investigative	[33]
4-Methanesulfonylamino-benzenesulfonamide	DMPH4C8	Discovery agent	N.A.	Investigative	[13]
4-Methoxy-3-pyridinesulfonamide	DMJIX7H	Discovery agent	N.A.	Investigative	[25]
4-methoxyphenylboronic acid	DMP5YFQ	Discovery agent	N.A.	Investigative	[17]
4-methylphenyl-difluoromethanesulfonamide	DMR5NLM	Discovery agent	N.A.	Investigative	[9]
4-methylstyrylboronic acid	DMW0Y29	Discovery agent	N.A.	Investigative	[17]
4-Methylthiopyridine-3-sulfonamide	DMEB5XP	Discovery agent	N.A.	Investigative	[25]
4-nitrophenyl phosphate	DMBX4UJ	Discovery agent	N.A.	Investigative	[34]
4-nitrophenyl-difluoromethanesulfonamide	DM9ETMD	Discovery agent	N.A.	Investigative	[9]
4-phenoxyphenylboronic acid	DMMWYI9	Discovery agent	N.A.	Investigative	[17]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide	DMH3UPO	Discovery agent	N.A.	Investigative	[28]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide	DMYESXB	Discovery agent	N.A.	Investigative	[28]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide	DMGXM9C	Discovery agent	N.A.	Investigative	[13]
5-Amino-[1,3,4]thiadiazole-2-thiol	DMGA47N	Discovery agent	N.A.	Investigative	[35]
5-Chlorosalicylic Acid	DMH397E	Discovery agent	N.A.	Investigative	[26]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one	DM5RI4H	Discovery agent	N.A.	Investigative	[36]
5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate	DMQ94BX	Discovery agent	N.A.	Investigative	[36]
6-(aminomethyl)-2H-chromen-2-one	DMJU9TG	Discovery agent	N.A.	Investigative	[20]
6-Amino-benzothiazole-2-sulfonic acid amide	DMWPELS	Discovery agent	N.A.	Investigative	[37]
6-Hydroxy-benzothiazole-2-sulfonic acid amide	DM2B4S5	Discovery agent	N.A.	Investigative	[38]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DM7WH82	Discovery agent	N.A.	Investigative	[20]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid	DMZ6HQL	Discovery agent	N.A.	Investigative	[20]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid	DMJITU0	Discovery agent	N.A.	Investigative	[20]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DMHCWY8	Discovery agent	N.A.	Investigative	[20]
Aminobenzolamide derivative	DMWYS0Z	Discovery agent	N.A.	Investigative	[39]
Azide	DM5XZYB	Discovery agent	N.A.	Investigative	[40]
BENZENESULFONAMIDE	DM3I8A1	Discovery agent	N.A.	Investigative	[41]
BENZOLAMIDE	DME5QPX	Discovery agent	N.A.	Investigative	[15]
Benzothiazole-2-sulfonic acid amide	DMROP5Q	Discovery agent	N.A.	Investigative	[42]
Beta-naphthylboronic acid	DMZ8Y67	Discovery agent	N.A.	Investigative	[17]
Biphenyl-4-ylboronic acid	DMIHMP5	Discovery agent	N.A.	Investigative	[17]
Carbamoyl phosphate disodium	DMZYK1W	Discovery agent	N.A.	Investigative	[43]
Carzenide	DMVD481	Discovery agent	N.A.	Investigative	[41]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[5]
CL-5343	DM9AFZ3	Solid tumour/cancer	2A00-2F9Z	Investigative	[2], [44]
Coumarin	DM0N8ZM	Discovery agent	N.A.	Investigative	[45]
CYANATE	DM6HQDL	Discovery agent	N.A.	Investigative	[40]
Cynooxide anion	DMZCA15	Discovery agent	N.A.	Investigative	[46]
Decane-1,10-diyl disulfamate	DM1ESVR	Discovery agent	N.A.	Investigative	[47]
Decyl sulfamate	DMIERWO	Discovery agent	N.A.	Investigative	[47]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[6]
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE	DMKJGLO	Discovery agent	N.A.	Investigative	[21]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[6]
HERNIARIN	DM9UASM	Discovery agent	N.A.	Investigative	[20]
Hexane-1,6-diamine	DMSHF0K	Discovery agent	N.A.	Investigative	[48]
HYDROSULFIDE	DMO32HN	Discovery agent	N.A.	Investigative	[40]
IODIDE	DM3FZ6P	Discovery agent	N.A.	Investigative	[8]
L-693612	DMMUYHX	Glaucoma/ocular hypertension	9C61	Investigative	[49], [50]
N-(4-cyanophenyl)sulfamide	DMW8S2D	Discovery agent	N.A.	Investigative	[51]
N-(4-Sulfamoyl-phenyl)-benzamide	DMZDACT	Discovery agent	N.A.	Investigative	[13]
N-(4-Sulfamoyl-phenyl)-butyramide	DM3FW9Q	Discovery agent	N.A.	Investigative	[13]
N-(4-Sulfamoyl-phenyl)-propionamide	DM7MHQD	Discovery agent	N.A.	Investigative	[13]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide	DM7QX03	Discovery agent	N.A.	Investigative	[52]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide	DMNQDLC	Discovery agent	N.A.	Investigative	[53]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide	DMSQEXP	Discovery agent	N.A.	Investigative	[35]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide	DMA21WB	Discovery agent	N.A.	Investigative	[53]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide	DM5E7OC	Discovery agent	N.A.	Investigative	[53]
N-(pentafluorophenyl)sulfamide	DME45J8	Discovery agent	N.A.	Investigative	[51]
N-1,3,4-thiadiazol-2-ylsulfamide	DMJ10WH	Discovery agent	N.A.	Investigative	[53]
N-hydroxysulfamide	DMTDBMU	Discovery agent	N.A.	Investigative	[54]
N-hydroxysulfonamides	DMJBC03	Discovery agent	N.A.	Investigative	[55]
N-propynyl amidebenzenesulphonide	DMWTPJH	Discovery agent	N.A.	Investigative	[56]
N-[4-(trifluoromethyl)phenyl]sulfamide	DMMX65T	Discovery agent	N.A.	Investigative	[51]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMSI4PE	Discovery agent	N.A.	Investigative	[53]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMXLJGR	Discovery agent	N.A.	Investigative	[53]
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE	DMX4QKU	Discovery agent	N.A.	Investigative	[21]
Nitrate	DMVFB93	Discovery agent	N.A.	Investigative	[8]
NSC-654077	DMW3QAK	Discovery agent	N.A.	Investigative	[18]
Octane-1,8-diyl disulfamate	DMBQMGH	Discovery agent	N.A.	Investigative	[47]
Octyl sulfamate	DM40ZCA	Discovery agent	N.A.	Investigative	[47]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[6]
Paraoxon	DMN4ZKC	Discovery agent	N.A.	Investigative	[34]
Pentane-1,5-diamine	DMVPZG9	Discovery agent	N.A.	Investigative	[48]
Pentanoic acid (4-sulfamoyl-phenyl)-amide	DMAZ07T	Discovery agent	N.A.	Investigative	[13]
Phenethylboronic acid	DMPDVG2	Discovery agent	N.A.	Investigative	[17]
Phenoxyarsonous acid	DMZJO5V	Discovery agent	N.A.	Investigative	[8]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[8]
PHENYLDIFLUOROMETHANESULFONAMIDE	DME75VC	Discovery agent	N.A.	Investigative	[9]
PHENYLMETHANESULFONAMIDE	DMGLDFI	Discovery agent	N.A.	Investigative	[9]
PHENYLSULFAMATE	DMRLFJV	Discovery agent	N.A.	Investigative	[9]
Prop-2-ynyl 4-sulfamoylbenzoate	DM8O41M	Discovery agent	N.A.	Investigative	[56]
Saccharin	DMRA736	Discovery agent	N.A.	Investigative	[29]
Sodium trithiocarbonate	DM6WYGC	Discovery agent	N.A.	Investigative	[57]
Styrylboronic acid	DMJ4Z7W	Discovery agent	N.A.	Investigative	[17]
SULFAMATE	DMF1589	Discovery agent	N.A.	Investigative	[8]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester	DM9XNSK	Discovery agent	N.A.	Investigative	[58]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester	DM7VBSY	Discovery agent	N.A.	Investigative	[58]
Sulfamic acid 3-sulfamoyloxy-phenyl ester	DMA0MEV	Discovery agent	N.A.	Investigative	[58]
Sulfamic acid 4-sulfamoyloxy-butyl ester	DMQZGNJ	Discovery agent	N.A.	Investigative	[58]
Sulfamic acid 6-sulfamoyloxy-hexyl ester	DMT3U2D	Discovery agent	N.A.	Investigative	[58]
Sulfamic acid 7-sulfamoyloxy-heptyl ester	DMVWEN3	Discovery agent	N.A.	Investigative	[58]
Sulfate	DMW0ZBF	Discovery agent	N.A.	Investigative	[8]
Syringic Acid	DM802V7	Discovery agent	N.A.	Investigative	[6]
Thioureido sulfonamide	DM8WYEM	Discovery agent	N.A.	Investigative	[59]
Trecadrine	DMDX0VI	Discovery agent	N.A.	Investigative	[60]
[Au(CN)2]-	DMN70VT	Discovery agent	N.A.	Investigative	[61]
[Cu(CN)2]-	DMV6NP1	Discovery agent	N.A.	Investigative	[61]

References

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• [5] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
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• [10] Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61.
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