Details of the Drug Combination

General Information of Drug Combination (ID: DCOSRRA)

Drug Combination Name
Melphalan Fludarabine
Indication
Disease Entry Status REF
Accelerated Phase Chronic Myelogenous Leukemia Phase 1 [1]
Component Drugs Melphalan   DMOLNHF Fludarabine   DMVRLT7
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Melphalan
Disease Entry ICD 11 Status REF
Hematologic disease 3C0Z Approved [2]
Leukemia N.A. Approved [2]
Multiple myeloma 2A83 Approved [3]
Myeloproliferative neoplasm 2A20 Approved [2]
Ovarian cancer 2C73 Approved [4]
Plasma cell myeloma 2A83.1 Approved [2]
Refractory plasma cell neoplasm N.A. Approved [2]
Intrahepatic cholangiocarcinoma 2C12.10 Phase 3 [5]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [6]
Classic Hodgkin lymphoma N.A. Investigative [2]
Neuroblastoma 2D11.2 Investigative [2]
Retinoblastoma 2D02.2 Investigative [2]
Melphalan Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [10]
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Melphalan Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
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Melphalan Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [12]
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Melphalan Interacts with 237 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Activity [13]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Activity [13]
BICD family-like cargo adapter 2 (BICDL2) OTK1LAIB BICL2_HUMAN Increases Expression [9]
RNA-binding protein MEX3A (MEX3A) OTB0OEQN MEX3A_HUMAN Increases Expression [9]
Transmembrane protein 131-like (TMEM131L) OT7MO7XU T131L_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 42 (ARHGAP42) OTIDSJMK RHG42_HUMAN Decreases Expression [9]
Aryl hydrocarbon receptor repressor (AHRR) OTSJ12W6 AHRR_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [9]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Decreases Expression [9]
Nucleolar protein 56 (NOP56) OTT67SRZ NOP56_HUMAN Increases Expression [9]
Pro-neuregulin-2, membrane-bound isoform (NRG2) OTMDE844 NRG2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Phosphorylation [14]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Expression [9]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) OTRBREQ9 ANR28_HUMAN Decreases Expression [9]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Affects Phosphorylation [15]
NF-kappa-B-repressing factor (NKRF) OTUVY0P6 NKRF_HUMAN Increases Expression [9]
Forkhead box protein P2 (FOXP2) OTVX6A59 FOXP2_HUMAN Decreases Expression [9]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Increases Expression [9]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) OTTK98BH CP27B_HUMAN Increases Expression [9]
Unconventional myosin-Ib (MYO1B) OTGZUJ0I MYO1B_HUMAN Decreases Expression [9]
Ephrin-A2 (EFNA2) OTEAUKRX EFNA2_HUMAN Increases Expression [9]
Kalirin (KALRN) OT8WRCBH KALRN_HUMAN Decreases Expression [9]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [9]
TBC1 domain family member 12 (TBC1D12) OTG0R7NT TBC12_HUMAN Decreases Expression [9]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Decreases Expression [9]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase CDC14B (CDC14B) OTAESVOZ CC14B_HUMAN Decreases Expression [9]
Thiamine transporter 1 (SLC19A2) OTH5SB0M S19A2_HUMAN Increases Expression [9]
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Decreases Expression [9]
SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) OTUWFMCQ SRGP2_HUMAN Decreases Expression [9]
Suppressor of cytokine signaling 5 (SOCS5) OTN1ABYR SOCS5_HUMAN Decreases Expression [9]
Nebulette (NEBL) OT2WH1NC NEBL_HUMAN Increases Expression [9]
Thymocyte selection-associated high mobility group box protein TOX (TOX) OTE8BL5Z TOX_HUMAN Decreases Expression [9]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [9]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [14]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [16]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [9]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [17]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [9]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [18]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [16]
Transcriptional activator GLI3 (GLI3) OTKDOE94 GLI3_HUMAN Decreases Expression [9]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [9]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [19]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Decreases Expression [9]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Decreases Expression [9]
Interleukin-7 (IL7) OTT6YSKM IL7_HUMAN Decreases Expression [9]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Decreases Expression [9]
Interferon regulatory factor 2 (IRF2) OTAZRUW3 IRF2_HUMAN Decreases Expression [9]
Beta-galactosidase (GLB1) OTB0TKAG BGAL_HUMAN Increases Expression [20]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [18]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [18]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) OT5MXG9W AT2B1_HUMAN Decreases Expression [9]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Decreases Expression [9]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [9]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [9]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [9]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Increases Expression [9]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) OTRA8ZVE PPIF_HUMAN Increases Expression [9]
MHC class II transactivator (CIITA) OTRJNZFO C2TA_HUMAN Decreases Expression [9]
G protein-coupled receptor kinase 5 (GRK5) OTJK79EK GRK5_HUMAN Decreases Expression [9]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [9]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [9]
Protein AF-9 (MLLT3) OTXH4DDG AF9_HUMAN Decreases Expression [9]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [21]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [9]
Large ribosomal subunit protein uL15 (RPL27A) OTQQHPL0 RL27A_HUMAN Increases Expression [9]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [9]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Increases Expression [9]
Homeobox protein MOX-2 (MEOX2) OTKZCJCB MEOX2_HUMAN Decreases Expression [9]
Ephrin-A5 (EFNA5) OTOH4DRR EFNA5_HUMAN Decreases Expression [9]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Decreases Expression [9]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [9]
Ephrin type-A receptor 5 (EPHA5) OTAM0CVX EPHA5_HUMAN Decreases Expression [9]
Growth arrest-specific protein 1 (GAS1) OTKJXG52 GAS1_HUMAN Decreases Expression [9]
GTP-binding protein RAD (RRAD) OTW2O4GD RAD_HUMAN Increases Expression [9]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [9]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [9]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [9]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Expression [9]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) OTSFVC82 2ABB_HUMAN Decreases Expression [9]
Fatty acid-binding protein 5 (FABP5) OTNM186C FABP5_HUMAN Increases Expression [9]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Decreases Expression [9]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) OTF6OC66 GCNT1_HUMAN Decreases Expression [9]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Decreases Expression [9]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [9]
AT-rich interactive domain-containing protein 5A (ARID5A) OTQT7CG9 ARI5A_HUMAN Increases Expression [9]
Homeobox protein EMX2 (EMX2) OT0V8OYK EMX2_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Increases Expression [9]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Decreases Expression [9]
Nuclear factor 1 A-type (NFIA) OTDHQ9CG NFIA_HUMAN Decreases Expression [9]
Urea transporter 1 (SLC14A1) OTH7UUV0 UT1_HUMAN Decreases Expression [9]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Decreases Expression [9]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Increases Expression [9]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Decreases Expression [9]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Decreases Expression [9]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) OT5VYOSM IKKE_HUMAN Decreases Expression [9]
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) OTV7ZA9O NMDE3_HUMAN Increases Expression [9]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) OTZBCRGI 2A5A_HUMAN Decreases Expression [9]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Increases Phosphorylation [9]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Increases Expression [9]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [19]
Tigger transposable element-derived protein 2 (TIGD2) OTRXGZ1X TIGD2_HUMAN Decreases Expression [9]
Fidgetin (FIGN) OTJF6EZR FIGN_HUMAN Decreases Expression [9]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Increases Expression [9]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Increases Expression [9]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Decreases Expression [9]
Janus kinase and microtubule-interacting protein 3 (JAKMIP3) OT4EDANR JKIP3_HUMAN Decreases Expression [9]
DENN domain-containing protein 4C (DENND4C) OT8SYN47 DEN4C_HUMAN Decreases Expression [9]
BTB/POZ domain-containing protein 8 (BTBD8) OT3A3RD7 BTBD8_HUMAN Decreases Expression [9]
Autophagy-related protein 16-1 (ATG16L1) OTEOYC5D A16L1_HUMAN Increases Expression [9]
Protein SPT2 homolog (SPTY2D1) OT1RY99Z SPT2_HUMAN Increases Expression [9]
Ankyrin repeat domain-containing protein 34A (ANKRD34A) OTI00ROL AN34A_HUMAN Decreases Expression [9]
AMMECR1-like protein (AMMECR1L) OTFPJEC1 AMERL_HUMAN Increases Expression [9]
RPA-related protein RADX (RADX) OTKV8BMJ RADX_HUMAN Decreases Expression [9]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Decreases Expression [9]
Alpha-(1,3)-fucosyltransferase 10 (FUT10) OT8TI57X FUT10_HUMAN Decreases Expression [9]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) OTXP4QH8 CNKR3_HUMAN Decreases Expression [9]
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) OTB1MTOI AB17C_HUMAN Decreases Expression [9]
Transmembrane protein 88 (TMEM88) OTA96YEL TMM88_HUMAN Increases Expression [9]
Actin remodeling regulator NHS (NHS) OTKE8QAT NHS_HUMAN Decreases Expression [9]
Coiled-coil domain-containing protein 171 (CCDC171) OT9NL2D9 CC171_HUMAN Decreases Expression [9]
BRCA1-A complex subunit Abraxas 1 (ABRAXAS1) OT1K4J80 ABRX1_HUMAN Decreases Expression [9]
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3) OT6TKZTU LRIG3_HUMAN Decreases Expression [9]
R-spondin-2 (RSPO2) OT3HHXU0 RSPO2_HUMAN Decreases Expression [9]
Protocadherin Fat 4 (FAT4) OT7QONNV FAT4_HUMAN Decreases Expression [9]
Thrombospondin type-1 domain-containing protein 4 (THSD4) OTXDBMDC THSD4_HUMAN Decreases Expression [9]
RNA-binding protein MEX3B (MEX3B) OTPUZ8CW MEX3B_HUMAN Increases Expression [9]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Decreases Expression [9]
Lysophospholipid acyltransferase 1 (MBOAT1) OT4XR6TE MBOA1_HUMAN Decreases Expression [9]
Protein MMS22-like (MMS22L) OTJI0HM9 MMS22_HUMAN Decreases Expression [9]
Transmembrane protein 26 (TMEM26) OTHZCXYB TMM26_HUMAN Decreases Expression [9]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) OTI0T62C FGD6_HUMAN Decreases Expression [9]
tRNA methyltransferase 10 homolog C (TRMT10C) OT1L8Q48 TM10C_HUMAN Increases Expression [9]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1) OTTOGO05 EEPD1_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RNF144B (RNF144B) OTN7FCDE R144B_HUMAN Decreases Expression [9]
Ankyrin and armadillo repeat-containing protein (ANKAR) OTR49F4J ANKAR_HUMAN Decreases Expression [9]
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) OTKX7P8G SPRE1_HUMAN Decreases Expression [9]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Decreases Expression [9]
Pleckstrin homology-like domain family B member 2 (PHLDB2) OTDKMB2G PHLB2_HUMAN Decreases Expression [9]
Transmembrane protein 200A (TMEM200A) OTVJZIOR T200A_HUMAN Decreases Expression [9]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) OTZQE7PW SMS1_HUMAN Decreases Expression [9]
Protein FAM90A1 (FAM90A1) OTN16PUT F90A1_HUMAN Decreases Expression [9]
Copine-8 (CPNE8) OTO6U97G CPNE8_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 12 (ARHGAP12) OTTU94AU RHG12_HUMAN Decreases Expression [9]
Cilia- and flagella-associated protein 206 (CFAP206) OTTKI6A9 CF206_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 24 (ARHGAP24) OTCQCEZS RHG24_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Decreases Expression [9]
Intraflagellar transport protein 70B (IFT70B) OT0LHUE4 IT70B_HUMAN Decreases Expression [9]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Increases Expression [9]
Kelch repeat and BTB domain-containing protein 3 (KBTBD3) OTTVABNZ KBTB3_HUMAN Decreases Expression [9]
Activin receptor type-1C (ACVR1C) OTOTYERF ACV1C_HUMAN Decreases Expression [9]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Decreases Expression [9]
Semaphorin-6D (SEMA6D) OTU0UAZS SEM6D_HUMAN Decreases Expression [9]
Exocyst complex component 6 (EXOC6) OTVVD62X EXOC6_HUMAN Decreases Expression [9]
Coiled-coil domain-containing protein 110 (CCDC110) OT1L2DWU CC110_HUMAN Decreases Expression [9]
Protein FAM110B (FAM110B) OTLYN2T1 F110B_HUMAN Decreases Expression [9]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) OT4WOLA8 ENOX1_HUMAN Decreases Expression [9]
CDK5 and ABL1 enzyme substrate 1 (CABLES1) OTMN4XSX CABL1_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RNF128 (RNF128) OTJO86CJ RN128_HUMAN Decreases Expression [9]
Sorting nexin-29 (SNX29) OTYMXH13 SNX29_HUMAN Decreases Expression [9]
Protein Shroom3 (SHROOM3) OTQKC5X2 SHRM3_HUMAN Decreases Expression [9]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Decreases Expression [9]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [9]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Decreases Expression [9]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [9]
PHD finger protein 3 (PHF3) OTNOYLG9 PHF3_HUMAN Decreases Expression [9]
Ras-like protein family member 10A (RASL10A) OTEXTN6I RSLAA_HUMAN Increases Expression [9]
Disks large homolog 3 (DLG3) OTH591WK DLG3_HUMAN Decreases Expression [9]
PHD finger protein 21A (PHF21A) OTU3FFG4 PF21A_HUMAN Decreases Expression [9]
AMSH-like protease (STAMBPL1) OTI4CYTF STALP_HUMAN Decreases Expression [9]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Decreases Expression [9]
ELL-associated factor 1 (EAF1) OTN27MJW EAF1_HUMAN Increases Expression [9]
Spermatogenesis-associated protein 17 (SPATA17) OT6SK923 SPT17_HUMAN Decreases Expression [9]
Leucine rich adaptor protein 1 (LURAP1) OTJ1EZDJ LURA1_HUMAN Decreases Expression [9]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) OTYXJQCW FGD4_HUMAN Decreases Expression [9]
Transcriptional-regulating factor 1 (TRERF1) OTA7UQF1 TREF1_HUMAN Decreases Expression [9]
Cbp/p300-interacting transactivator 4 (CITED4) OTR6NHI2 CITE4_HUMAN Increases Expression [9]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [9]
SH3 and cysteine-rich domain-containing protein (STAC) OTRVBSLR STAC_HUMAN Decreases Expression [9]
Lysosomal-trafficking regulator (LYST) OTIUB1B3 LYST_HUMAN Decreases Expression [9]
Ras-like protein family member 11B (RASL11B) OTHEVZS6 RSLBB_HUMAN Increases Expression [9]
Metastasis-associated protein MTA3 (MTA3) OTIA6C79 MTA3_HUMAN Decreases Expression [9]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [9]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Decreases Expression [9]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) OTA0DE43 B3GN5_HUMAN Increases Expression [9]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Decreases Expression [9]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Increases Expression [9]
CYFIP-related Rac1 interactor A (CYRIA) OT2VJ767 CYRIA_HUMAN Decreases Expression [9]
Talin rod domain-containing protein 1 (TLNRD1) OTNOLROI TLRN1_HUMAN Increases Expression [9]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [9]
Protein bicaudal C homolog 1 (BICC1) OTYRKIJ1 BICC1_HUMAN Decreases Expression [9]
GRB2-associated and regulator of MAPK protein 1 (GAREM1) OTQYIOUN GARE1_HUMAN Decreases Expression [9]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) OT2MNW8T PKHA5_HUMAN Decreases Expression [9]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase Jade-2 (JADE2) OTVG2MYF JADE2_HUMAN Decreases Expression [9]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [9]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Decreases Expression [9]
Ankyrin repeat domain-containing protein 10 (ANKRD10) OTIZ2VK8 ANR10_HUMAN Increases Expression [9]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) OTE69HV8 B3GN2_HUMAN Increases Expression [9]
PH and SEC7 domain-containing protein 3 (PSD3) OTTN9B9O PSD3_HUMAN Decreases Expression [9]
Formin-2 (FMN2) OTUY7BSV FMN2_HUMAN Decreases Expression [9]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Decreases Expression [9]
Spermatogenesis-associated protein 7 (SPATA7) OT78G2IH SPAT7_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 20 (ARHGAP20) OTG1STV8 RHG20_HUMAN Decreases Expression [9]
Coiled-coil and C2 domain-containing protein 2A (CC2D2A) OTFGRGFR C2D2A_HUMAN Decreases Expression [9]
Kelch-like protein 42 (KLHL42) OTK6WARI KLH42_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase HECW2 (HECW2) OTP2IN12 HECW2_HUMAN Decreases Expression [9]
FERM domain-containing protein 4A (FRMD4A) OTJDTIK2 FRM4A_HUMAN Decreases Expression [9]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Expression [9]
Transcription factor COE1 (EBF1) OTZ61YYH COE1_HUMAN Decreases Expression [9]
Cdc42 effector protein 3 (CDC42EP3) OTUZ3U9Z BORG2_HUMAN Decreases Expression [9]
Zinc finger protein Helios (IKZF2) OTZIMARJ IKZF2_HUMAN Decreases Expression [9]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Decreases Expression [9]
Protein phosphatase 1H (PPM1H) OTKSVU7S PPM1H_HUMAN Decreases Expression [9]
Activator of basal transcription 1 (ABT1) OT9YGIDB ABT1_HUMAN Increases Expression [9]
Trinucleotide repeat-containing gene 6B protein (TNRC6B) OTGVT0SH TNR6B_HUMAN Decreases Expression [9]
Inactive phospholipase C-like protein 2 (PLCL2) OTK5FDF6 PLCL2_HUMAN Decreases Expression [9]
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) OTSQTPFQ SHAN2_HUMAN Decreases Expression [9]
Sodium channel protein type 8 subunit alpha (SCN8A) OT0JGIZN SCN8A_HUMAN Decreases Expression [9]
Dexamethasone-induced Ras-related protein 1 (RASD1) OT2BAJHK RASD1_HUMAN Increases Expression [9]
FERM domain-containing protein 4B (FRMD4B) OTVI6YFP FRM4B_HUMAN Decreases Expression [9]
Microtubule cross-linking factor 1 (MTCL1) OTY9ZKHE MTCL1_HUMAN Decreases Expression [9]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Decreases Expression [9]
Krueppel-like factor 12 (KLF12) OTVH4KD4 KLF12_HUMAN Decreases Expression [9]
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Decreases Response To Substance [22]
Microsomal glutathione S-transferase 2 (MGST2) OT4UGTDO MGST2_HUMAN Decreases Response To Substance [23]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Response To Substance [24]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases ADR [25]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Affects Export [26]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Affects Response To Substance [27]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases ADR [25]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Response To Substance [28]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Increases Response To Substance [24]
Elongator complex protein 1 (ELP1) OTYEWBF7 ELP1_HUMAN Increases ADR [25]
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⏷ Show the Full List of 237 DOT(s)
Indication(s) of Fludarabine
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [7]
Cutaneous melanoma 2C30 Approved [7]
Haematological malignancy 2B33.Y Approved [8]
Hematologic disease 3C0Z Approved [7]
Hepatosplenic T-cell lymphoma N.A. Approved [7]
Immunodeficiency 4A00-4A85 Approved [7]
Large granular lymphocytic leukemia 2A90.1 Approved [7]
Lung cancer 2C25.0 Approved [7]
MALT lymphoma N.A. Approved [7]
Multiple sclerosis 8A40 Approved [7]
Myeloproliferative neoplasm 2A20 Approved [7]
Nodal marginal zone lymphoma 2A85.0 Approved [7]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [7]
Recurrent adult burkitt lymphoma 2A85.6 Approved [7]
Small intestine lymphoma N.A. Approved [7]
Splenic marginal zone lymphoma N.A. Approved [7]
Systemic lupus erythematosus 4A40.0 Approved [7]
Systemic sclerosis 4A42 Approved [7]
Testicular lymphoma N.A. Approved [7]
Classic Hodgkin lymphoma N.A. Investigative [7]
Colon cancer 2B90.Z Investigative [7]
Gastric cancer 2B72 Investigative [7]
Neuroblastoma 2D11.2 Investigative [7]
Fludarabine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [32]
------------------------------------------------------------------------------------
Fludarabine Interacts with 22 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Affects Expression [33]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [34]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [34]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [35]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [36]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [29]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [37]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [38]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [30]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [30]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Activity [39]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Increases Activity [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [35]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [37]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [38]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Activity [39]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [36]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [36]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [37]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [30]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [31]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [35]
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⏷ Show the Full List of 22 DOT(s)

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