Details of the Drug Combination

General Information of Drug Combination (ID: DCPC7VB)

Drug Combination Name
Zidovudine Lamivudine
Indication
Disease Entry Status REF
Human Immunodeficiency Virus Phase 3 [1]
Component Drugs Zidovudine   DM4KI7O Lamivudine   DMI347A
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Zidovudine
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [2]
Diarrhea ME05.1 Investigative [3]
Nephropathy GC2Z Investigative [3]
Virus infection 1A24-1D9Z Investigative [4]
Zidovudine Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Inhibitor [12]
Fms-like tyrosine kinase 3 (FLT-3) TTGJCWZ FLT3_HUMAN Binder [13]
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Zidovudine Interacts with 8 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [15]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [16]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [17]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [17]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [16]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [16]
Organic anion transporter 4 (SLC22A11) DT06JWZ S22AB_HUMAN Substrate [16]
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⏷ Show the Full List of 8 DTP(s)
Zidovudine Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [18]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [19]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [20]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [20]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [20]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [20]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [21]
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⏷ Show the Full List of 7 DME(s)
Zidovudine Interacts with 172 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Expression [8]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [22]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [8]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [22]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Increases Expression [8]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Increases Methylation [23]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [24]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) OTYZ8XRH DHSD_HUMAN Increases Expression [25]
Acyl carrier protein, mitochondrial (NDUFAB1) OTF906UR ACPM_HUMAN Increases Expression [25]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Expression [26]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [8]
Monocarboxylate transporter 5 (SLC16A4) OT1YXBKC MOT5_HUMAN Increases Expression [8]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [8]
Protein SLC31A2 (SLC31A2) OTQC136Q COPT2_HUMAN Increases Expression [8]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [8]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [22]
Phospholipid-transporting ATPase IC (ATP8B1) OTALGS63 AT8B1_HUMAN Decreases Expression [25]
NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) OTQAA1B8 NDUB5_HUMAN Increases Expression [25]
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) OTDV12IF NDUB3_HUMAN Increases Expression [25]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Increases Expression [25]
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) OT6CLFXB MCAT_HUMAN Increases Expression [8]
NADH dehydrogenase iron-sulfur protein 5 (NDUFS5) OTF40UYJ NDUS5_HUMAN Increases Expression [25]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [27]
Thiamine transporter 1 (SLC19A2) OTH5SB0M S19A2_HUMAN Decreases Expression [8]
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) OTBT8KW9 NDUS2_HUMAN Decreases Expression [25]
NADH dehydrogenase iron-sulfur protein 6, mitochondrial (NDUFS6) OT9IOONQ NDUS6_HUMAN Increases Expression [25]
Citrate synthase, mitochondrial (CS) OTYLYXMO CISY_HUMAN Decreases Expression [28]
ATP synthase subunit g, mitochondrial (ATP5MG) OTD569IJ ATP5L_HUMAN Increases Expression [25]
Organic cation/carnitine transporter 2 (SLC22A5) OTC36TYB S22A5_HUMAN Increases Expression [8]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [8]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Increases Expression [25]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Increases Expression [8]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Affects Expression [29]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Decreases Expression [8]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Decreases Expression [26]
Cytochrome b (CYTB) OTAHB98A CYB_HUMAN Affects Expression [29]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Increases Expression [25]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Increases Expression [25]
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Increases Expression [25]
Interferon alpha-1/13 (IFNA1) OTPMKY0L IFNA1_HUMAN Affects Expression [30]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [31]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [32]
NADH-ubiquinone oxidoreductase chain 1 (ND1) OTCLGIXV NU1M_HUMAN Increases Expression [25]
NADH-ubiquinone oxidoreductase chain 2 (ND2) OTG9OHOX NU2M_HUMAN Increases Expression [25]
NADH-ubiquinone oxidoreductase chain 4 (ND4) OT4RQVAA NU4M_HUMAN Increases Expression [25]
NADH-ubiquinone oxidoreductase chain 5 (ND5) OT45LW1K NU5M_HUMAN Increases Expression [25]
Anion exchange protein 2 (SLC4A2) OTLJIEOH B3A2_HUMAN Increases Expression [8]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [33]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [8]
P3 protein (SLC10A3) OTUBZ4HT P3_HUMAN Increases Expression [8]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Decreases Expression [34]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Decreases Expression [34]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Affects Expression [33]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [8]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [35]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) OTVT146E CX7A2_HUMAN Increases Expression [25]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Affects Expression [29]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Affects Expression [29]
N-chimaerin (CHN1) OTM196M3 CHIN_HUMAN Decreases Expression [25]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Decreases Expression [34]
Erythroid transcription factor (GATA1) OTX1R7O1 GATA1_HUMAN Decreases Expression [36]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [37]
Solute carrier family 25 member 16 (SLC25A16) OTTTUL91 GDC_HUMAN Increases Expression [8]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Increases Expression [25]
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) OTP0961M COX5A_HUMAN Decreases Expression [34]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Decreases Expression [25]
Methylmalonyl-CoA mutase, mitochondrial (MMUT) OTBBBV70 MUTA_HUMAN Increases Expression [38]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1) OTHV25GG CX7A1_HUMAN Decreases Expression [34]
Cytochrome c oxidase subunit 7B, mitochondrial (COX7B) OT67PIDP COX7B_HUMAN Increases Expression [25]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Increases Expression [25]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Increases Expression [10]
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) OTTIZDFR NDUS1_HUMAN Increases Expression [25]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Decreases Expression [25]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [24]
General transcription factor IIH subunit 1 (GTF2H1) OTCRXC6B TF2H1_HUMAN Increases Expression [10]
ATP-binding cassette sub-family D member 1 (ABCD1) OT3FL9W0 ABCD1_HUMAN Increases Expression [8]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [24]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [8]
Lon protease homolog, mitochondrial (LONP1) OT665WYT LONM_HUMAN Affects Expression [33]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [39]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [8]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [33]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [40]
Sodium- and chloride-dependent creatine transporter 1 (SLC6A8) OT88C8JA SC6A8_HUMAN Decreases Expression [8]
ATP synthase subunit O, mitochondrial (ATP5PO) OTU3MCTN ATPO_HUMAN Increases Expression [25]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Increases Expression [8]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Increases Expression [25]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) OTEVK4WW NDUV1_HUMAN Decreases Expression [25]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Increases Expression [8]
Cationic amino acid transporter 2 (SLC7A2) OTAMWBVM CTR2_HUMAN Decreases Expression [8]
Tricarboxylate transport protein, mitochondrial (SLC25A1) OTIDXQ9F TXTP_HUMAN Increases Expression [8]
Sodium/myo-inositol cotransporter (SLC5A3) OT6FY2KA SC5A3_HUMAN Decreases Expression [8]
ATP synthase subunit e, mitochondrial (ATP5ME) OTADVEE2 ATP5I_HUMAN Increases Expression [25]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6) OTEOIIOL NDUA6_HUMAN Increases Expression [25]
Glucose-6-phosphate exchanger SLC37A1 (SLC37A1) OTSYK97W G6PT2_HUMAN Increases Expression [8]
Poly(rC)-binding protein 4 (PCBP4) OTDLL4NB PCBP4_HUMAN Increases Expression [41]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [41]
b(0,+)-type amino acid transporter 1 (SLC7A9) OTMNY2WA BAT1_HUMAN Increases Expression [8]
Vigilin (HDLBP) OTKDEEYX VIGLN_HUMAN Decreases Expression [25]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [8]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Increases Expression [8]
Sodium-dependent phosphate transporter 2 (SLC20A2) OT6E2DAX S20A2_HUMAN Increases Expression [8]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Affects Expression [29]
Metal cation symporter ZIP14 (SLC39A14) OTGR686L S39AE_HUMAN Decreases Expression [8]
Transcription factor NF-E2 45 kDa subunit (NFE2) OTLM94BI NFE2_HUMAN Decreases Expression [36]
NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) OTMKQJJ8 NDUA9_HUMAN Increases Expression [25]
ATP-binding cassette sub-family C member 10 (ABCC10) OT2JRWWJ MRP7_HUMAN Increases Expression [8]
Proton-coupled zinc antiporter SLC30A9, mitochondrial (SLC30A9) OT2AN3VH ZNT9_HUMAN Increases Expression [8]
Heme A synthase COX15 (COX15) OTUIYHIW COX15_HUMAN Decreases Expression [25]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [42]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [8]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Expression [8]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Expression [8]
Solute carrier family 35 member F2 (SLC35F2) OTSAD4EQ S35F2_HUMAN Increases Expression [8]
Solute carrier family 22 member 15 (SLC22A15) OT60WAAI S22AF_HUMAN Decreases Expression [8]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [8]
Phospholipid-transporting ATPase ABCA7 (ABCA7) OT51S50X ABCA7_HUMAN Decreases Expression [8]
Vesicular glutamate transporter 3 (SLC17A8) OTQULEQ4 VGLU3_HUMAN Increases Expression [8]
Zinc transporter 7 (SLC30A7) OTC55IN4 ZNT7_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Decreases Expression [8]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2) OTH77FBE G6PT3_HUMAN Increases Expression [8]
Solute carrier family 22 member 17 (SLC22A17) OTLBYGOY S22AH_HUMAN Increases Expression [8]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Decreases Expression [8]
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) OTRDOV1Y S13A3_HUMAN Decreases Expression [8]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Decreases Expression [8]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [43]
Nucleotide sugar transporter SLC35B4 (SLC35B4) OTPW52JT S35B4_HUMAN Increases Expression [8]
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) OT3J1G7H SO4A1_HUMAN Decreases Expression [8]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Increases Expression [8]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Increases Expression [8]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Decreases Expression [8]
Bifunctional polynucleotide phosphatase/kinase (PNKP) OTXJNXVW PNKP_HUMAN Increases Expression [41]
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) OTEY876E ZNT3_HUMAN Increases Expression [8]
Phospholipid-transporting ATPase ABCA3 (ABCA3) OTH6MSKQ ABCA3_HUMAN Increases Expression [8]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [8]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Increases Expression [8]
Solute carrier family 12 member 9 (SLC12A9) OTR7VRAK S12A9_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) OTNC55HX GTR11_HUMAN Increases Expression [8]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Increases Expression [8]
Thiamine transporter 2 (SLC19A3) OTOWP1CT S19A3_HUMAN Decreases Expression [8]
Solute carrier family 22 member 4 (SLC22A4) OT4LOVI9 S22A4_HUMAN Increases Expression [8]
Sulfate anion transporter 1 (SLC26A1) OTBJVDTD S26A1_HUMAN Increases Expression [8]
Solute carrier family 28 member 3 (SLC28A3) OT5TLTYU S28A3_HUMAN Increases Expression [8]
ABC-type oligopeptide transporter ABCB9 (ABCB9) OTSOBOL5 ABCB9_HUMAN Increases Expression [8]
Asc-type amino acid transporter 1 (SLC7A10) OTN1S03Q AAA1_HUMAN Decreases Expression [8]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) OTMEF544 SIR3_HUMAN Increases Expression [33]
Nucleotide sugar transporter SLC35D1 (SLC35D1) OTAQ6YWB S35D1_HUMAN Increases Expression [8]
Zinc transporter ZIP9 (SLC39A9) OTBVVFSK S39A9_HUMAN Increases Expression [8]
ATP-binding cassette sub-family F member 3 (ABCF3) OTLBYTTN ABCF3_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) OTPT2I7B SL2A8_HUMAN Increases Expression [8]
Mitochondrial dicarboxylate carrier (SLC25A10) OTT8647H DIC_HUMAN Increases Expression [8]
ATP-binding cassette sub-family F member 2 (ABCF2) OTXIBZ3N ABCF2_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Increases Expression [8]
Large neutral amino acids transporter small subunit 2 (SLC7A8) OT8XXVO8 LAT2_HUMAN Increases Expression [8]
Zinc transporter ZIP10 (SLC39A10) OT04411Q S39AA_HUMAN Decreases Expression [8]
Y+L amino acid transporter 1 (SLC7A7) OTYNABBR YLAT1_HUMAN Increases Expression [8]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [8]
Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11) OT0N3WL9 COX11_HUMAN Decreases Expression [25]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Increases ADR [44]
ADP/ATP translocase 2 (SLC25A5) OT1XIBMN ADT2_HUMAN Increases ADR [44]
DNA-directed RNA polymerase, mitochondrial (POLRMT) OT5Q8ZUJ RPOM_HUMAN Increases ADR [44]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases ADR [44]
Tumor suppressor ARF (CDKN2A) OTBOQ73Y ARF_HUMAN Increases ADR [44]
p21 protein (HRAS) OTFYE6AJ P78460_HUMAN Increases ADR [44]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Increases ADR [44]
Replicase polyprotein 1ab (rep) OTMJ5H6Y R1AB_SARS Increases ADR [44]
Nuclear respiratory factor 1 (NRF1) OTOXWNV8 NRF1_HUMAN Increases ADR [44]
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Increases ADR [44]
NADH-cytochrome b5 reductase 3 (CYB5R3) OTUGT3G8 NB5R3_HUMAN Increases ADR [44]
Sodium/nucleoside cotransporter 1 (SLC28A1) OTXWVV9O S28A1_HUMAN Affects Transport [45]
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⏷ Show the Full List of 172 DOT(s)
Indication(s) of Lamivudine
Disease Entry ICD 11 Status REF
Chronic HBV infection 1E51.0Z Approved [5]
Chronic hepatitis B virus infection N.A. Approved [6]
Human immunodeficiency virus infection 1C62 Approved [5]
Human immunodeficiency virus-1 infection 1C62 Approved [7]
Diarrhea ME05.1 Investigative [6]
Lamivudine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Modulator [46]
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Lamivudine Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [47]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [48]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [49]
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Lamivudine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Deoxy-5'-nucleotidase 1 (NT5C) DE4E31Z NT5C_HUMAN Metabolism [50]
Phosphorylcholine transferase A (PCYT1A) DEQYXD4 PCY1A_HUMAN Metabolism [51]
Phosphorylethanolamine transferase (PCYT2) DEIX1PO PCY2_HUMAN Metabolism [51]
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Lamivudine Interacts with 14 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Increases Uptake [52]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Increases Uptake [52]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [27]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [53]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [53]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [54]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [32]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [53]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [24]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Increases Expression [55]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [24]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [24]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Decreases Expression [54]
Solute carrier family 22 member 3 (SLC22A3) OTQYGVXX S22A3_HUMAN Increases Uptake [52]
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⏷ Show the Full List of 14 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Malaria DC4OLI4 N. A. Phase 3 [56]
HIV Infections DCZJZHV N. A. Phase 3 [57]
HIV Infections DCGON3K N. A. Phase 2 [58]
HIV DCH0XO7 N. A. Phase 1 [59]
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References

1 ClinicalTrials.gov (NCT03988452) Nucleosides And Darunavir/Dolutegravir In Africa
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56 ClinicalTrials.gov (NCT00993031) Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women
57 ClinicalTrials.gov (NCT02181933) Efficacy of Nevirapine Compared to ZDV + 3TC Administered in Labor and Again at Postdelivery in HIV Positive Women
58 ClinicalTrials.gov (NCT00307151) Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
59 ClinicalTrials.gov (NCT00960622) Switch From Combivir or Trizivir to Truvada - Mitochondrial Effects