Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1TMA3)

Drug Name

Imiquimod Drug Info

Synonyms

Aldara; Beselna; Zartra; Zyclara; Imiquimod acetate; R 837; S 26308; Aldara (TN); Aldara, Imiquimod; Beselna (TN); DZ-2636; Imiquimod [USAN:INN]; MTD-39; R-837; S-26308; TMX-101; Imiquimod (JAN/USAN/INN); 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 3M Brand of Imiquimod; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline

Indication

Disease Entry	ICD 11	Status	REF
Alopecia areata	ED70.2	Approved	[1]
Condyloma	1A95	Approved	[1]
Glioblastoma	2A00	Approved	[1]
Melanoma	2C30	Approved	[1]
Skin cancer	2C30-2C37	Approved	[2]

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID: 57469
ChEBI ID: CHEMBL1282
CAS Number: CAS 99011-02-6
TTD Drug ID: DM1TMA3
INTEDE Drug ID: DR0864

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Toll-like receptor 7 (TLR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[8]
ANA773	DMSC8YW	Hepatitis C virus infection	1E51.1	Phase 2a	[9]
GS-9620	DMG5C8D	Hepatitis B virus infection	1E51.0	Phase 2	[10]
IMO-3100	DMM549D	Psoriasis vulgaris	EA90	Phase 2	[11]
Resiquimod	DML6XSP	Actinic keratosis	EK90.0	Phase 2	[12]
LOXORIBINE	DMIV9ZE	Immune System disease	4A01-4B41	Phase 2	[13]
GSK2245035	DMBWPZJ	Asthma	CA23	Phase 2	[14]
AZD-8848	DM0M7QW	Allergic rhinitis	CA08.0	Phase 2	[15]
Isatoribine	DMHOJ8W	Hepatitis C virus infection	1E51.1	Phase 2	[16]
PF-4878691	DM24I0N	Melanoma	2C30	Phase 2	[17]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[27]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[33]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[35]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[41]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[49]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[52]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[56]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[59]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[63]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[75]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[76]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[68]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[80]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[81]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[82]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[83]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[84]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[85]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[84]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[80]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[37]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 7 (TLR7)	TTRJ1K4	TLR7_HUMAN	Agonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[5]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Regulation of Drug Effects	[6]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Protein Interaction/Cellular Processes	[5]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[7]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Protein Interaction/Cellular Processes	[5]

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References

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