Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1TMA3)

Drug Name
Imiquimod Drug Info
Synonyms
Aldara; Beselna; Zartra; Zyclara; Imiquimod acetate; R 837; S 26308; Aldara (TN); Aldara, Imiquimod; Beselna (TN); DZ-2636; Imiquimod [USAN:INN]; MTD-39; R-837; S-26308; TMX-101; Imiquimod (JAN/USAN/INN); 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 3M Brand of Imiquimod; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
Indication
Disease Entry ICD 11 Status REF
Alopecia areata ED70.2 Approved [1]
Condyloma 1A95 Approved [1]
Glioblastoma 2A00 Approved [1]
Melanoma 2C30 Approved [1]
Skin cancer 2C30-2C37 Approved [2]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
57469
ChEBI ID
CHEBI:36704
CAS Number
CAS 99011-02-6
TTD Drug ID
DM1TMA3
INTEDE Drug ID
DR0864

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Toll-like receptor 7 (TLR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [11]
ANA773 DMSC8YW Hepatitis C virus infection 1E51.1 Phase 2a [12]
GS-9620 DMG5C8D Hepatitis B virus infection 1E51.0 Phase 2 [13]
IMO-3100 DMM549D Psoriasis vulgaris EA90 Phase 2 [14]
Resiquimod DML6XSP Actinic keratosis EK90.0 Phase 2 [15]
LOXORIBINE DMIV9ZE Immune System disease 4A01-4B41 Phase 2 [16]
GSK2245035 DMBWPZJ Asthma CA23 Phase 2 [17]
AZD-8848 DM0M7QW Allergic rhinitis CA08.0 Phase 2 [18]
Isatoribine DMHOJ8W Hepatitis C virus infection 1E51.1 Phase 2 [19]
PF-4878691 DM24I0N Melanoma 2C30 Phase 2 [20]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [39]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [39]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [39]
Capsaicin DMGMF6V Back pain ME84.Z Approved [40]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [41]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [42]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [43]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [44]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [45]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [46]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Prednisone DM2HG4X Acute asthma CA23 Approved [51]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [59]
Selenium DM25CGV N. A. N. A. Approved [61]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [62]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [63]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [64]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [65]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [66]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [67]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [68]
Prednisone DM2HG4X Acute asthma CA23 Approved [69]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [74]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [77]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Diazepam DM08E9O Alcohol withdrawal Approved [84]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [89]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [92]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [77]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [96]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [59]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [97]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [100]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [102]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [107]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [111]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [117]
Gefitinib DM15F0X Colon adenocarcinoma Approved [118]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [121]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [113]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [122]
Paclitaxel DMLB81S Breast carcinoma Approved [123]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [131]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [132]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [133]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [134]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [137]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [138]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [139]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [140]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [143]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [144]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [145]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [147]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [148]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [150]
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Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [46]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [155]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [156]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [157]
Folic Acid DMEMBJC Colorectal carcinoma Approved [158]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [159]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [160]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [161]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [162]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [163]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [164]
Ethacrynic acid DM60QMR Edema MG29 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [166]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [167]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [168]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [170]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [171]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [172]
Capsaicin DMGMF6V Back pain ME84.Z Approved [40]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [173]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [42]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [173]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [170]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [46]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [175]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [176]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [177]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [178]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [179]
Capsaicin DMGMF6V Back pain ME84.Z Approved [40]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [173]
Quinidine DMLPICK N. A. N. A. Approved [180]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [181]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 7 (TLR7) TTRJ1K4 TLR7_HUMAN Agonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Protein Interaction/Cellular Processes [6]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Biotransformations [9]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [9]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Regulation of Drug Effects [9]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Regulation of Drug Effects [9]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Gene/Protein Processing [10]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [7]

References

1 Imiquimod FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5003).
3 Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov;129(11):2676-85.
4 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
5 Imiquimod induces apoptosis of human melanocytes. Arch Dermatol Res. 2010 May;302(4):301-6. doi: 10.1007/s00403-009-1012-0. Epub 2009 Dec 23.
6 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
7 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
8 Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J Natl Cancer Inst. 2003 Aug 6;95(15):1138-49. doi: 10.1093/jnci/djg016.
9 The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Arch Toxicol. 2019 Jul;93(7):1917-1926.
10 Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
11 TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35.
12 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
13 Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. J Pharmacol Exp Ther. 2014 Jan;348(1):96-105.
14 Company report (Iderapharma)
15 TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
16 The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
17 Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80.
18 Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012 Jun 22;13:53.
19 Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40.
20 The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.
21 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
22 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
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