Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCHGF1)

Drug Name
CHLORANIL Drug Info
Synonyms
Chloranil; 118-75-2; p-Chloranil; Tetrachloro-p-benzoquinone; Tetrachloro-1,4-benzoquinone; Tetrachlorobenzoquinone; 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione; Spergon; Coversan; Vulklor; Reranil; 2,3,5,6-TETRACHLORO-1,4-BENZOQUINONE; Psorisan; Khloranil; Tetrachloroparabenzoquinone; Spergon technical; Spergon I; Tetrachloroquinone; Chloranile; Quinone tetrachloride; Tetrachloro-p-quinone; Geigy-444E; 2,3,5,6-Tetrachlorobenzo-1,4-quinone; 2,3,5,6-Tetrachloro-p-benzoquinone; Dow Seed Disinfectant No. 5
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
8371
ChEBI ID
CHEMBL192627
CAS Number
CAS 118-75-2
TTD Drug ID
DMCHGF1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [7]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [8]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [9]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [10]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [11]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [12]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [13]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [14]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [15]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [16]
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Drug(s) Targeting Liver carboxylesterase (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [17]
PACTIMIBE DM0NZDT Arteriosclerosis BD40 Phase 2/3 [18]
K-604 DMQVN6P Arteriosclerosis BD40 Phase 2 [19]
Eldacimibe DML7WP0 Hyperlipidaemia 5C80 Phase 2 [20]
GR148672X DM7W6YN Acute lymphoblastic leukaemia 2A85 Clinical trial [21]
Avasimibe DMFG4OM Peripheral vascular disease BD4Z Discontinued in Phase 3 [22]
E-5324 DM562BM Hyperlipidaemia 5C80 Discontinued in Phase 2 [23]
RP-64477 DMTQ3BS Hyperlipidaemia 5C80 Discontinued in Phase 2 [24]
CI-976 DMBO28J Hyperlipidaemia 5C80 Discontinued in Phase 2 [25]
CL-283796 DM7LIDT Hyperlipidaemia 5C80 Discontinued in Phase 2 [26]
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Drug(s) Targeting Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hexafluronium bromide DMFY307 Spasm MB47.3 Approved [27]
MEPTAZINOL DMPSB8F Pain MG30-MG3Z Approved [28]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [29]
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [30]
Plasma derived human butyrylcholinesterase DMF3IBC Neurotoxicity NE61 Phase 1 [31]
Protexia DME1Y9W Alzheimer disease 8A20 Phase 1 [32]
JES-9501 DMYR3IE Alzheimer disease 8A20 Phase 1 [33]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [34]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [34]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [34]
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Drug(s) Affected By Golgi SNAP receptor complex member 2 (GOSR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [40]
Bortezomib DMNO38U Leukemia Approved [41]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [42]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [44]
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Drug(s) Affected By Ferritin light chain (FTL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Ethanol DMDRQZU Chronic pain MG30 Approved [53]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [69]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [70]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [67]
Ethacrynic acid DM60QMR Edema MG29 Approved [71]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Sorbitol DMAN0DE Constipation DD91.1 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
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Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [80]
Panobinostat DM58WKG Chronic graft versus host disease Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [83]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
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Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Selenium DM25CGV N. A. N. A. Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [83]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [98]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [99]
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Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ethanol DMDRQZU Chronic pain MG30 Approved [103]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [104]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [42]
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Drug(s) Affected By F-box only protein 32 (FBXO32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [110]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [111]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [112]
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Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
Ethanol DMDRQZU Chronic pain MG30 Approved [103]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [118]
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Drug(s) Affected By Endothelial cell-specific molecule 1 (ESM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [121]
Ampicillin DMHWE7P Acute epiglottitis Approved [119]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [42]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [122]
Arsenic DMTL2Y1 N. A. N. A. Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [124]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [125]
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Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ethanol DMDRQZU Chronic pain MG30 Approved [127]
Menthol DMG2KW7 Back pain ME84.Z Approved [128]
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Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ethanol DMDRQZU Chronic pain MG30 Approved [129]
Menthol DMG2KW7 Back pain ME84.Z Approved [128]
Arsenic DMTL2Y1 N. A. N. A. Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [131]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [132]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [117]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [133]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [134]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [1]
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Gene/Protein Processing [2]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [2]
Endothelial cell-specific molecule 1 (ESM1) OT331Y8V ESM1_HUMAN Gene/Protein Processing [3]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Gene/Protein Processing [3]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Gene/Protein Processing [3]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Gene/Protein Processing [3]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [4]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Post-Translational Modifications [6]

References

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2 Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1 in the HUVEC Endothelial Cell Line. Chem Res Toxicol. 2016 Mar 21;29(3):421-9. doi: 10.1021/acs.chemrestox.6b00021. Epub 2016 Mar 1.
3 Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res. 2014 Feb;42(3):1593-605. doi: 10.1093/nar/gkt1090. Epub 2013 Nov 8.
4 Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016 Dec 19;29(12):2184-2193. doi: 10.1021/acs.chemrestox.6b00369. Epub 2016 Nov 21.
5 Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation. Chem Res Toxicol. 2015 Apr 20;28(4):765-74. doi: 10.1021/tx500513v. Epub 2015 Mar 11.
6 Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling. Toxicology. 2016 Jul 1;363-364:48-57. doi: 10.1016/j.tox.2016.07.002. Epub 2016 Jul 5.
7 Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
9 Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40.
10 [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33.
11 Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
12 Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.
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14 Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66.
15 The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
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17 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
18 Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and b... J Med Chem. 2008 Aug 14;51(15):4823-33.
19 A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7.
20 Prospects for drug therapy for hyperlipoproteinaemia. Diabete Metab. 1995 Apr;21(2):139-46.
21 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592).
22 New advances in lipid-modifying therapies for reducing cardiovascular risk. Cardiology. 2002;97(2):59-66.
23 Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201.
24 RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.
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26 ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys. J Lipid Res. 1995 Jun;36(6):1199-210.
27 Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90.
28 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
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30 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
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33 Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
34 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.
35 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
36 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
37 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
38 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
39 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
40 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
41 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
42 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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