General Information of Drug (ID: DMH3OUX)

Drug Name
N-nonylphenol Drug Info
Synonyms
Nonylphenol (mixed); Phenol, 4-nonyl-; Phenol, nonyl derivs.; Phenol, p-nonyl-; p -n -Nonylphenol; p-Nonylphenol; p-n-Nonylphenol; p-nonyl phenol; 4-N-nonylphenol; para Nonyl phenol; para-Nonylphenol; 1-(4-Hydroxyphenyl)nonane; 104-40-5; 4-NP; 4-Nonyl Phenol-13C6; 4-Nonyl-Phenol; 4-n-Nonyl phenol; 4-n-Nonylphenol; 4-nonyl phenol; 4-nonylphenol; 68081-86-7; BRN 2047450; CCRIS 1251; CHEBI:34440; DSSTox_CID_1857; IGFHQQFPSIBGKE-UHFFFAOYSA-N; DSSTox_GSID_33836; DSSTox_RID_79098; EINECS 203-199-4; HSDB 5359; MFCD00002396; P-NONYLPHENOL (ENDOCRINE DISRUPTER)
Cross-matching ID
PubChem CID
1752
ChEBI ID
CHEMBL153062
CAS Number
CAS 104-40-5
TTD Drug ID
DMH3OUX
INTEDE Drug ID
DR1985

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Metabolized By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [1]
Abiraterone acetate DMANBZI Prostate cancer 2C82.0 Approved [9]
Vonoprazan DMO6315 Helicobacter infection DA42-DA63 Approved [10]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [11]
ASP-015K DMZ1UOI Psoriasis vulgaris EA90 Phase 3 [12]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [13]
daidzein DMRFTJX Discovery agent N.A. Investigative [1]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1]
Tetramethylbutylphenol DMW9CH2 N. A. N. A. Investigative [1]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [14]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [14]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [17]
Etidronic acid DM1XHYJ Bone Paget disease Approved [14]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [14]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [14]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [18]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [19]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [24]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [25]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [8]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [8]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Artemether DM48QOT Malaria 1F40-1F45 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [32]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [33]
Estrone DM5T6US Acne vulgaris ED80 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [44]
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Drug(s) Affected By CCN family member 5 (CCN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [46]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [46]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [50]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [51]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Capsaicin DMGMF6V Back pain ME84.Z Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Fructose DM43AN2 Vomiting MD90 Approved [70]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [72]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [72]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [72]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [77]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
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Drug(s) Affected By Ski-like protein (SKIL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Leflunomide DMR8ONJ Arthritis FA20 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Arsenic DMTL2Y1 N. A. N. A. Approved [87]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [84]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [91]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [92]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [2]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [2]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [2]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [79]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
Etretinate DM2CZFA Keratosis ED56 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [98]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [99]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [104]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [106]
Prednisone DM2HG4X Acute asthma CA23 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Prednisone DM2HG4X Acute asthma CA23 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Fluoxetine DM3PD2C Bipolar depression Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [120]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [125]
Estrone DM5T6US Acne vulgaris ED80 Approved [126]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Mestranol DMG3F94 Contraception QA21 Approved [124]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [128]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [2]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [2]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [2]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Ethanol DMDRQZU Chronic pain MG30 Approved [24]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [129]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [130]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [2]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [2]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [2]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [131]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [131]
Gefitinib DM15F0X Colon adenocarcinoma Approved [132]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [75]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [133]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [137]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [138]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Sulfotransferase 2A1 (SULT2A1) Main DME DE0P6LK ST2A1_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Gene/Protein Processing [2]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [3]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Gene/Protein Processing [6]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Gene/Protein Processing [2]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [7]
Lysosome-associated membrane glycoprotein 3 (LAMP3) OTN0XL3W LAMP3_HUMAN Gene/Protein Processing [8]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Gene/Protein Processing [2]

References

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2 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
3 The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures. Mol Cell Endocrinol. 2016 Jul 5;429:41-9. doi: 10.1016/j.mce.2016.03.034. Epub 2016 Mar 30.
4 Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect. 2013 Apr;121(4):459-66. doi: 10.1289/ehp.1205951. Epub 2013 Feb 5.
5 Influence of hexabromocyclododecane and 4-nonylphenol on the regulation of cell growth, apoptosis and migration in prostatic cancer cells. Toxicol In Vitro. 2016 Apr;32:240-7. doi: 10.1016/j.tiv.2016.01.008. Epub 2016 Jan 19.
6 Low concentrations of Bisphenol A and para-Nonylphenol affect extravillous pathway of human trophoblast cells. Mol Cell Endocrinol. 2015 Sep 5;412:56-64. doi: 10.1016/j.mce.2015.05.023. Epub 2015 May 28.
7 Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells. Int J Mol Sci. 2020 May 25;21(10):3735. doi: 10.3390/ijms21103735.
8 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
9 Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24.
10 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.
11 Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9.
12 Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor. Xenobiotica. 2015;45(10):887-902.
13 Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
14 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
15 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
16 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
17 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
18 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
19 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
20 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
21 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
22 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
23 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
24 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
25 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
26 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
27 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
28 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
29 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
30 Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
31 Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
32 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
33 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
34 Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
35 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
36 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
37 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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