Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH3OUX)

• Drug Name: N-nonylphenol Drug Info
• Synonyms: Nonylphenol (mixed); Phenol, 4-nonyl-; Phenol, nonyl derivs.; Phenol, p-nonyl-; p -n -Nonylphenol; p-Nonylphenol; p-n-Nonylphenol; p-nonyl phenol; 4-N-nonylphenol; para Nonyl phenol; para-Nonylphenol; 1-(4-Hydroxyphenyl)nonane; 104-40-5; 4-NP; 4-Nonyl Phenol-13C6; 4-Nonyl-Phenol; 4-n-Nonyl phenol; 4-n-Nonylphenol; 4-nonyl phenol; 4-nonylphenol; 68081-86-7; BRN 2047450; CCRIS 1251; CHEBI:34440; DSSTox_CID_1857; IGFHQQFPSIBGKE-UHFFFAOYSA-N; DSSTox_GSID_33836; DSSTox_RID_79098; EINECS 203-199-4; HSDB 5359; MFCD00002396; P-NONYLPHENOL (ENDOCRINE DISRUPTER)
• Cross-matching ID:
  PubChem CID: 1752
  ChEBI ID: CHEBI:34440
  CAS Number: CAS 104-40-5
  TTD Drug ID: DMH3OUX
  INTEDE Drug ID: DR1985

Molecule-Related Drug Atlas

Drug(s) Metabolized By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1]
Abiraterone acetate	DMANBZI	Prostate cancer	2C82.0	Approved	[10]
Vonoprazan	DMO6315	Helicobacter infection	DA42-DA63	Approved	[11]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[12]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[13]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1]
BCP-13498	DM2BO9W	N. A.	N. A.	Phase 2	[14]
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[1]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1]
Tetramethylbutylphenol	DMW9CH2	N. A.	N. A.	Investigative	[1]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[16]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[30]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[31]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[32]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[35]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[32]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[32]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[37]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[41]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[42]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[43]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[44]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[45]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[46]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[47]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[64]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[65]
Fructose	DM43AN2	Vomiting	MD90	Approved	[66]
Ketoprofen	DMRKXPT	Bursitis		Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[70]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[81]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[15]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[15]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[85]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[87]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[88]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[93]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[97]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[103]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[104]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[105]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[112]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[120]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[121]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[126]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[125]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[134]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[135]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[139]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[140]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[148]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fructose	DM43AN2	Vomiting	MD90	Approved	[151]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[152]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[153]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[153]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[153]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[153]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[164]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[165]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[166]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[171]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[174]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[175]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[176]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[180]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[148]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[183]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[190]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[193]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[195]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[196]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[199]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[200]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[203]

Drug(s) Affected By Ski-like protein (SKIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[208]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[212]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[213]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[5]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[5]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[5]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[216]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[104]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[227]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[228]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[231]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[234]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[200]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[237]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[239]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[244]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[245]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[250]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[251]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[252]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[253]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[254]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[255]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[237]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[256]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[231]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[239]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[265]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[271]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[272]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[273]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[274]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[190]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[275]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[195]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[276]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[277]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[201]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[237]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[281]
Mestranol	DMG3F94	Contraception	QA21	Approved	[278]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[273]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[5]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[5]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[5]

Drug(s) Affected By Early estrogen-induced gene 1 protein (EEIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[282]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[5]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[5]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[82]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[285]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[286]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[287]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Mestranol	DMG3F94	Contraception	QA21	Approved	[290]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[291]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[282]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[66]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[297]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[301]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[302]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[303]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[304]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]

Drug(s) Affected By Sulfotransferase 1B1 (SULT1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[305]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[310]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[311]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[312]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[313]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[314]

Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[316]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[317]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[318]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[319]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[305]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[304]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 2A1 (SULT2A1) Main DME	DE0P6LK	ST2A1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[2]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[3]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Protein Interaction/Cellular Processes	[4]
Beta-1,4-galactosyltransferase 1 (B4GALT1)	OTBCXEK7	B4GT1_HUMAN	Gene/Protein Processing	[5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[6]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Gene/Protein Processing	[7]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Gene/Protein Processing	[8]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Post-Translational Modifications	[9]

References

• [1] Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8.
• [2] Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands. Environ Sci. 2005;12(4):219-30.
• [3] [Effects of three environmental estrogens on expression of proliferation and apoptosis-associated genes in PEO4 cells]. Wei Sheng Yan Jiu. 2004 Jul;33(4):404-6.
• [4] Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. Asian J Androl. 2010 Jul;12(4):535-47. doi: 10.1038/aja.2010.14. Epub 2010 May 3.
• [5] Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
• [6] The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures. Mol Cell Endocrinol. 2016 Jul 5;429:41-9. doi: 10.1016/j.mce.2016.03.034. Epub 2016 Mar 30.
• [7] Influence of hexabromocyclododecane and 4-nonylphenol on the regulation of cell growth, apoptosis and migration in prostatic cancer cells. Toxicol In Vitro. 2016 Apr;32:240-7. doi: 10.1016/j.tiv.2016.01.008. Epub 2016 Jan 19.
• [8] Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect. 2013 Apr;121(4):459-66. doi: 10.1289/ehp.1205951. Epub 2013 Feb 5.
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