Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIZKOP)

Drug Name
Thiotepa Drug Info
Synonyms
thiotepa; THIO-TEPA; 52-24-4; Triethylenethiophosphoramide; Thiophosphamide; Tiofosyl; Tiofosfamid; Thiofozil; Tiofozil; Thioplex; Tespamin; Oncotepa; Tespamine; Girostan; Thiotef; Stepa; Tio-tef; Thio-Tep; Oncotiotepa; Tifosyl; Oncothio-tepa; TESPA; TSPA; Thio-tepa S; Ledertepa; Thiotriethylenephosphoramide; TIO TEF; N,N',N''-Triethylenethiophosphoramide; Tris(1-aziridinyl)phosphine sulfide; Thiophosphamidum; 1,1',1''-phosphorothioyltriaziridine; Triethylene thiophosphoramide; Triaziridinylphosphine sulfide
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Immunodeficiency 4A00-4A85 Approved [2]
Leukemia Approved [2]
Urinary bladder cancer Approved [2]
Classic Hodgkin lymphoma Investigative [2]
Neuroblastoma 2D11.2 Investigative [2]
Cross-matching ID
PubChem CID
5453
ChEBI ID
CHEBI:9570
CAS Number
CAS 52-24-4
TTD Drug ID
DMIZKOP
VARIDT Drug ID
DR00862
INTEDE Drug ID
DR1583
ACDINA Drug ID
D01482

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [8]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [9]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [13]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [14]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [15]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [29]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [30]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [31]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [31]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [32]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [33]
Capsaicin DMGMF6V Back pain ME84.Z Approved [34]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [35]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [20]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [21]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [22]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [23]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [24]
Ethacrynic acid DM60QMR Edema MG29 Approved [25]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [26]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Ethacrynic acid DM60QMR Edema MG29 Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [46]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [47]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [48]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [49]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [50]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [51]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [52]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [53]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [54]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [55]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [56]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [57]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [67]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [68]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [69]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [72]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [73]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [55]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [76]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Meloxicam DM2AR7L Arthritis FA20 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [97]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [98]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [5]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [106]
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Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [110]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [111]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [112]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [113]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [114]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [115]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [116]
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Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [118]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [120]
Leflunomide DMR8ONJ Arthritis FA20 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
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Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [131]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [132]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [136]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [137]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [138]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [139]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [140]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [140]
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Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Ethanol DMDRQZU Chronic pain MG30 Approved [145]
Folic Acid DMEMBJC Colorectal carcinoma Approved [146]
Paclitaxel DMLB81S Breast carcinoma Approved [147]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [148]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [149]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [151]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [151]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [152]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [84]
Etretinate DM2CZFA Keratosis ED56 Approved [154]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [155]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Gefitinib DM15F0X Colon adenocarcinoma Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [33]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [33]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [162]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [163]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [165]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [166]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Gene/Protein Processing [5]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Drug Response [6]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Drug Response [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [5]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [5]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [7]

References

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2 Thiotepa FDA Label
3 Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol. 2002 Jun;49(6):461-7.
4 Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys. 1999 Jun 1;366(1):89-94.
5 Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
6 Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenet Genomics. 2008 Nov;18(11):1009-15. doi: 10.1097/FPC.0b013e328313aaa4.
7 The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation. Drug Metab Dispos. 2005 Jun;33(6):795-802.
8 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
9 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
10 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
11 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
12 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
13 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
14 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
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16 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
17 Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55.
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20 Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3.
21 Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos. 1995 Jan;23(1):119-23.
22 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
23 Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
24 Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
25 Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7.
26 Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.
27 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
28 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
29 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
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32 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
33 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
34 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
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