Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM9Z0B)

Drug Name
2-hydroxy-17beta-estradiol Drug Info
Synonyms
2-Hydroxyestradiol; 2-OH-Estradiol; 362-05-0; 2-hydroxy-estradiol; 2-OH-E2; (17beta)-Estra-1,3,5(10)-triene-2,3,17-triol; UNII-AYU2L67YUU; Estra-1,3,5(10)-triene-2,3,17beta-triol; CHEBI:28744; NSC 61711; AYU2L67YUU; 2-Hydroxy-17; MLS000069506; CHEMBL467987; DILDHNKDVHLEQB-XSSYPUMDSA-N; ESTRA-1,3,5(10)-TRIENE-2,3,17-beta-TRIOL; SMR000058615; ECS; CCRIS 8709; 2bw7
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
247304
ChEBI ID
CHEMBL467987
CAS Number
CAS 362-05-0
TTD Drug ID
DMM9Z0B
INTEDE Drug ID
DR1974

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adenylate cyclase (ADCY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ad5-AC6 DMQNFZE Cardiac failure BD10-BD13 Terminated [8]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [9]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [10]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [9]
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [1]
2,5-didesoxy-3-ATP DM5CWM0 Discovery agent N.A. Investigative [1]
N. A. N. A. [11]
N. A. N. A. [11]
N. A. N. A. [11]
N. A. N. A. [11]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A6 (UGT1A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [14]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [15]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [16]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [17]
Naproxen DMZ5RGV Bursitis Approved [18]
Deferiprone DMS2M7O Beta thalassemia 3A50.2 Approved [19]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [2]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [20]
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Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [25]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [3]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [27]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [27]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [28]
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Drug(s) Affected By ATP synthase subunit a (ATP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [40]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Fructose DM43AN2 Vomiting MD90 Approved [46]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [48]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [48]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [48]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenylate cyclase (ADCY) TT2QM9D NOUNIPROTAC Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A6 (UGT1A6) Main DME DESD26P UD16_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Gene/Protein Processing [3]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Gene/Protein Processing [3]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [4]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Gene/Protein Processing [5]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Biotransformations [6]
UDP-glucuronosyltransferase 1A10 OTOTZVEY UD110_HUMAN Biotransformations [7]
UDP-glucuronosyltransferase 1A3 OTUEOER3 UD13_HUMAN Biotransformations [7]
UDP-glucuronosyltransferase 1A7 OTY4JJ32 UD17_HUMAN Biotransformations [7]
UDP-glucuronosyltransferase 1A8 OTTMABBG UD18_HUMAN Biotransformations [7]

References

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21 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
22 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
23 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
24 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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29 Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes. Toxicol Appl Pharmacol. 2022 Mar 15;439:115929. doi: 10.1016/j.taap.2022.115929. Epub 2022 Feb 21.
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