Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM9Z0B)

Drug Name
2-hydroxy-17beta-estradiol Drug Info
Synonyms
2-Hydroxyestradiol; 2-OH-Estradiol; 362-05-0; 2-hydroxy-estradiol; 2-OH-E2; (17beta)-Estra-1,3,5(10)-triene-2,3,17-triol; UNII-AYU2L67YUU; Estra-1,3,5(10)-triene-2,3,17beta-triol; CHEBI:28744; NSC 61711; AYU2L67YUU; 2-Hydroxy-17; MLS000069506; CHEMBL467987; DILDHNKDVHLEQB-XSSYPUMDSA-N; ESTRA-1,3,5(10)-TRIENE-2,3,17-beta-TRIOL; SMR000058615; ECS; CCRIS 8709; 2bw7
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
247304
ChEBI ID
CHEBI:28744
CAS Number
CAS 362-05-0
TTD Drug ID
DMM9Z0B
INTEDE Drug ID
DR1974

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adenylate cyclase (ADCY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ad5-AC6 DMQNFZE Cardiac failure BD10-BD13 Terminated [9]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [10]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [11]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [10]
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [1]
2,5-didesoxy-3-ATP DM5CWM0 Discovery agent N.A. Investigative [1]
N. A. N. A. [12]
N. A. N. A. [12]
N. A. N. A. [12]
N. A. N. A. [12]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A6 (UGT1A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [15]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [18]
Naproxen DMZ5RGV Bursitis Approved [19]
Deferiprone DMS2M7O Beta thalassemia 3A50.2 Approved [20]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [2]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [21]
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Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [26]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [3]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [28]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [29]
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Drug(s) Affected By ATP synthase subunit a (ATP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [25]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [40]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [41]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [49]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [50]
Aripiprazole DM3NUMH Bipolar I disorder Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [52]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [53]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Fructose DM43AN2 Vomiting MD90 Approved [56]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [57]
Estrone DM5T6US Acne vulgaris ED80 Approved [58]
Testosterone DM7HUNW Hot flushes GA30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [58]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [58]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [58]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [64]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [68]
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Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ethanol DMDRQZU Chronic pain MG30 Approved [72]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [73]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [74]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [75]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [76]
Epinephrine DM3KJBC Acute asthma CA23 Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Selenium DM25CGV N. A. N. A. Approved [85]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
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Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [87]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Estrone DM5T6US Acne vulgaris ED80 Approved [89]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [87]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [89]
Ethanol DMDRQZU Chronic pain MG30 Approved [72]
Folic Acid DMEMBJC Colorectal carcinoma Approved [90]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [91]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [92]
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Drug(s) Affected By Forkhead box protein O1 (FOXO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [99]
Leflunomide DMR8ONJ Arthritis FA20 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Estrone DM5T6US Acne vulgaris ED80 Approved [102]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [104]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Mestranol DMG3F94 Contraception QA21 Approved [107]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [108]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [69]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [109]
Minoxidil DMA2Z4F Alopecia ED70 Approved [77]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [111]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [112]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [113]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [114]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [115]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Ethacrynic acid DM60QMR Edema MG29 Approved [117]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [118]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [119]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [120]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [121]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [121]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [121]
Capsaicin DMGMF6V Back pain ME84.Z Approved [122]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [123]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [124]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [125]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [126]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [127]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [128]
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Drug(s) Affected By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [4]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [4]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [4]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [129]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [131]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [133]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [135]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [136]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [137]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [138]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [139]
Capsaicin DMGMF6V Back pain ME84.Z Approved [140]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [141]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenylate cyclase (ADCY) TT2QM9D NOUNIPROTAC Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A6 (UGT1A6) Main DME DESD26P UD16_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Gene/Protein Processing [3]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [4]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Biotransformations [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [6]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Biotransformations [6]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Gene/Protein Processing [7]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Gene/Protein Processing [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [7]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Gene/Protein Processing [8]

References

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6 Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. Drug Metab Dispos. 2006 Sep;34(9):1606-14.
7 Catechol estrogens induce proliferation and malignant transformation in prostate epithelial cells. Toxicol Lett. 2013 Jul 18;220(3):247-58. doi: 10.1016/j.toxlet.2013.05.002. Epub 2013 May 15.
8 Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor: Short title: Kynurenine action on human decidualization. Reprod Toxicol. 2020 Sep;96:282-292. doi: 10.1016/j.reprotox.2020.07.011. Epub 2020 Aug 8.
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13 UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables. Drug Metab Dispos. 2011 Sep;39(9):1650-7.
14 UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6.
15 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
16 Pharmacokinetics of propofol and extrahepatic UGT1A6 gene expression in anhepatic rats. Pharmacology. 2009;84(4):219-26.
17 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.
18 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
19 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
20 Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos. 2009 Feb;37(2):322-9.
21 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
22 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
23 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
24 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
25 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
26 Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount. Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78. doi: 10.1042/BA20060223.
27 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
28 An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007 Jun 15;73(12):1927-38. doi: 10.1016/j.bcp.2007.03.014. Epub 2007 Mar 20.
29 Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
30 Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes. Toxicol Appl Pharmacol. 2022 Mar 15;439:115929. doi: 10.1016/j.taap.2022.115929. Epub 2022 Feb 21.
31 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
32 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
33 Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
34 The identification of cellular targets of 17 estradiol using a lytic (T7) cDNA phage display approach. Toxicol In Vitro. 2011 Feb;25(1):388-93. doi: 10.1016/j.tiv.2010.10.012. Epub 2010 Oct 27.
35 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
36 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
37 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
38 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
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