Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOUC09)

• Drug Name: Norepinephrine Drug Info
• Synonyms: norepinephrine; L-Noradrenaline; Levarterenol; 51-41-2; L-Norepinephrine; Levophed; (-)-Norepinephrine; L-arterenol; (R)-Noradrenaline; (R)-Norepinephrine; Levonor; Levonorepinephrine; Adrenor; Aktamin; Levonoradrenaline; Sympathin E; (R)-(-)-Norepinephrine; 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol; Noradrenalin; Norepirenamine; norepinephrinum; Noradrenalinum; Levoarterenol; Norartrinal; Nor-Epirenan; L-3,4-dihydroxyphenylethanolamine; Levarterenolo; Noreinefrina; Norepinefrina; Norepinephrinum; Levarterenolo [DCIT]; Nor adrenalin; Noradrenalina [Italian]; Norepinephrine Noradrenalin; LT03330026; ALBB-006229; Nor adrenalin (TN); Noradrenaline (JP15); Noreinefrina [INN-Spanish]; Norepinephrine (INN); Norepinephrine [INN:JAN]; Norepinephrinum [INN-Latin]; Norepinephrine l-Tartrate (1:1); D-(-)-Noradrenaline; D53D5E3A-2360-4CA9-8031-6C2CD4062FD5; L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol; L-1-(3,4-Dihydroxyphenyl)-2-aminoethanol; L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol; (-)-(R)-Norepinephrine; (-)-Arterenol free base; (-)-alpha-(Aminomethyl)protocatechuyl alcohol; (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI); 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol; Ecteinascidins

Indication

Disease Entry	ICD 11	Status	REF
Alopecia	ED70	Approved	[1]
Bronchiectasis	CA24	Approved	[1]
Bronchitis	CA20	Approved	[1]
Chronic fatigue syndrome	8E49	Approved	[1]
Depression	6A70-6A7Z	Approved	[1]
Psychosexual disorder		Approved	[1]
Pulmonary emphysema	CA21.Z	Approved	[1]
Pure autonomic failure		Approved	[1]
Radiodermatitis		Approved	[1]
Sepsis	1G40-1G41	Approved	[2]
Severe asthma	CA23	Approved	[1]
Asthma	CA23	Investigative	[1]

• Therapeutic Class: Vasoconstrictor Agents
• Cross-matching ID:
  PubChem CID: 439260
  ChEBI ID: CHEMBL1437
  CAS Number: CAS 51-41-2
  TTD Drug ID: DMOUC09
  VARIDT Drug ID: DR00268

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[18]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[19]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[20]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[20]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[20]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[21]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[22]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[23]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[24]
Nadolol	DMW6GVL	Angina pectoris	BA40	Approved	[25]

Drug(s) Transported By Organic cation transporter 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[28]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[29]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[7]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[30]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[31]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[32]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[30]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[33]

Drug(s) Transported By Organic cation transporter 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[30]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[7]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[34]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[30]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[35]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[7]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[36]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[37]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[38]
Etilefrine	DM67PWD	Cardiovascular disease	BA00-BE2Z	Withdrawn from market	[39]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[43]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[44]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[45]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[46]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[8]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[30]

Drug(s) Transported By Vesicular amine transporter 2 (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[5]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[47]
Methamphetamine	DMPM4SK	Anxiety		Approved	[48]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[5]

Drug(s) Transported By Vesicular amine transporter 1 (SLC18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[5]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[49]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[5]

Drug(s) Transported By Sodium-dependent noradrenaline transporter (SLC6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[50]

Drug(s) Transported By Sodium- and chloride-dependent glycine transporter 2 (SLC6A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[51]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[52]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[13]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[58]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[59]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[60]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[70]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[74]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[77]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Protein S100-B (S100B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[86]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[87]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[88]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]

Drug(s) Affected By Myosin light chain 1/3, skeletal muscle isoform (MYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[94]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[98]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[103]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[104]
Terbutaline	DMD4381	Asthma	CA23	Approved	[105]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[106]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[111]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[112]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[121]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]

Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[9]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[132]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[133]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Terbutaline	DMD4381	Asthma	CA23	Approved	[134]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[10]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[135]

Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[136]
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[133]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[137]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[132]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[146]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[147]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[148]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[152]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[86]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[153]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[137]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[156]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[162]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[165]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[166]

Drug(s) Affected By Equilibrative nucleoside transporter 4 (SLC29A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[169]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[170]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Stimulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium- and chloride-dependent glycine transporter 2 (SLC6A5)	DTE8R17	SC6A5_HUMAN	Substrate	[4]
Vesicular amine transporter 2 (SLC18A2)	DTT7VPB	VMAT2_HUMAN	Substrate	[5]
Vesicular amine transporter 1 (SLC18A1)	DTM953D	VMAT1_HUMAN	Substrate	[5]
Sodium-dependent noradrenaline transporter (SLC6A2)	DT9JBVI	SC6A2_HUMAN	Substrate	[6]
Organic cation transporter 3 (SLC22A3)	DT6201N	S22A3_HUMAN	Substrate	[7]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[8]
Organic cation transporter 2 (SLC22A2)	DT9IDPW	S22A2_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-1A adrenergic receptor (ADRA1A)	OTUIWCL5	ADA1A_HUMAN	Protein Interaction/Cellular Processes	[9]
Alpha-1D adrenergic receptor (ADRA1D)	OTW2CD1O	ADA1D_HUMAN	Protein Interaction/Cellular Processes	[10]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Protein Interaction/Cellular Processes	[11]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Protein Interaction/Cellular Processes	[12]
Equilibrative nucleoside transporter 4 (SLC29A4)	OTWTZXMX	S29A4_HUMAN	Regulation of Drug Effects	[13]
Myosin light chain 1/3, skeletal muscle isoform (MYL1)	OTDUYR4U	MYL1_HUMAN	Post-Translational Modifications	[14]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Regulation of Drug Effects	[15]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Protein Interaction/Cellular Processes	[16]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Drug Response	[17]
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)	OT4AVU95	MYPT1_HUMAN	Post-Translational Modifications	[14]

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