Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQCTIH)

Drug Name
Digoxin Drug Info
Synonyms
digoxin; 20830-75-5; 12beta-Hydroxydigitoxin; Digoxine; Lanoxin; Lanoxicaps; Digossina; Digoxina; Digoxinum; Digosin; Lanicor; Digacin; Dilanacin; CHEBI:4551; MLS000069819; Lanacordin; Cardiogoxin; Eudigox; Davoxin; SMR000059217; Rougoxin; Mapluxin; Lenoxin; Lanacrist; Dynamos; Vanoxin; Neo-Lanicor; Lanoxin PG; Digoxin Pediatric; Digoxin Nativelle; SK-Digoxin; UNII-73K4184T59; Homolle's digitalin; Hemigoxine Nativelle; MFCD00003674; Digitek (TN); Lanoxicaps (TN); Lanoxin (TN); Digoxin (JP15/USP); (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide; 4-[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11,16-dihydroxy-2,15-dimethyltetracyclo[8700^{2,7}; [3H]digoxin
Indication
Disease Entry ICD 11 Status REF
Arrhythmia BC9Z Approved [1]
Atrial fibrillation BC81.3 Approved [2]
Chronic heart failure BD1Z Approved [2]
Congestive cardiac insufficiency BD1Z Approved [1]
Heart failure BD10-BD13 Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
2724385
ChEBI ID
CHEMBL1751
CAS Number
CAS 20830-75-5
TTD Drug ID
DMQCTIH
VARIDT Drug ID
DR00148
INTEDE Drug ID
DR0498
ACDINA Drug ID
D00198

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium/potassium-transporting ATPase (SPT ATPase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Digitoxin DMWVIGP Arrhythmia BC9Z Approved [19]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [20]
Rostafuroxin DMKQXDB Hypertension BA00-BA04 Phase 2 [21]
PBI-05204 DM05WIU Pancreatic cancer 2C10 Phase 2 [22]
RX108 DM4XETK Solid tumour/cancer 2A00-2F9Z Phase 1 [23]
Istaroxime DMWN09H Cardiac disease BA00-BE2Z Discontinued in Phase 2 [24]
Cordil DMQESM7 Heart arrhythmia BC65 Terminated [25]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [26]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
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Drug(s) Transported By Multidrug resistance protein 3 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [5]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [33]
Paclitaxel DMLB81S Breast carcinoma Approved [5]
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [35]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [38]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [39]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [40]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [41]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [40]
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Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [42]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [43]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [46]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [48]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [49]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [50]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [51]
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Drug(s) Transported By Organic solute transporter subunit alpha (SLC51A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [6]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [6]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [6]
Drug(s) Transported By Organic solute transporter subunit beta (SLC51B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [6]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [6]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [6]
Sodium taurocholate DM3GO0J Type-2 diabetes 5A11 Phase 1/2 [52]
Drug(s) Transported By Organic anion transporting polypeptide 4C1 (SLCO4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liothyronine DM6IR3P Congenital hypothyroidism Approved [7]
Saxagliptin DMGXENV Type-2 diabetes 5A11 Approved [53]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [7]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [54]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [56]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [62]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [63]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [66]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [67]
Cepharanthine DM9Y5JB N. A. N. A. Approved [68]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [69]
Clozapine DMFC71L Schizophrenia 6A20 Approved [70]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [71]
Trifluoperazine DMKBYWI Anxiety Approved [72]
Olanzapine DMPFN6Y Bipolar depression Approved [70]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [73]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Testosterone enanthate DMB6871 N. A. N. A. Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [15]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [81]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [82]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [85]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [88]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [95]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [15]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [98]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [99]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [103]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [104]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [112]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [114]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [94]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [115]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [120]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [122]
Ethanol DMDRQZU Chronic pain MG30 Approved [123]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [124]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [124]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [18]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [126]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [130]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [131]
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Drug(s) Affected By p21 protein (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Indomethacin DMSC4A7 Bursitis Approved [18]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [18]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Organic anion transporter M1 (SLCO4C1) TTACFNR SO4C1_HUMAN Modulator [3]
Sodium/potassium-transporting ATPase (SPT ATPase) TTQ38E9 AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance protein 3 (ABCB4) DTZRMK5 MDR3_HUMAN Substrate [5]
Organic solute transporter subunit alpha (SLC51A) DTMEQ32 OSTA_HUMAN Substrate [6]
Organic solute transporter subunit beta (SLC51B) DT1V9AJ OSTB_HUMAN Substrate [6]
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTY0QMU SO4C1_HUMAN Substrate [7]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [8]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [9]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [11]
Cardiac glycoside reductase 2 (cgr2) DE9VSLW CGR2_EGGLE Substrate [12]
Cardiac glycoside reductase 1 (cgr1) DE84PFW CGR1_EGGLE Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [13]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [14]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [15]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [15]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [15]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Gene/Protein Processing [15]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [16]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Gene/Protein Processing [17]
p21 protein (HRAS) OTFYE6AJ P78460_HUMAN Drug Response [18]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [15]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4726).
2 Digoxin FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1227).
4 Fab antibody fragments: some applications in clinical toxicology. Drug Saf. 2004;27(14):1115-33.
5 MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9.
6 Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82.
7 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74.
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9 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
10 MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun. 2010 Jul 16;398(1):7-12.
11 Omeprazole-associated digoxin toxicity. South Med J. 2007 Apr;100(4):400-2.
12 Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.
13 Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):385-92. doi: 10.1016/j.taap.2009.07.026. Epub 2009 Jul 30.
14 Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. J Pharmacol Exp Ther. 2005 Jan;312(1):144-52. doi: 10.1124/jpet.104.073916. Epub 2004 Sep 13.
15 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
16 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
17 Chronic digoxin toxicity and significantly elevated BNP levels in the presence of mild heart failure. Am J Emerg Med. 2005 Jul;23(4):561-2. doi: 10.1016/j.ajem.2004.10.009.
18 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
19 Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7.
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21 Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35.
22 First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf- beta and p70s6k, in patients with advanced solid tumors. Invest New Drugs. 2014 Dec;32(6):1204-12.
23 ClinicalTrials.gov (NCT03646071) A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
24 Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8.
25 WO patent application no. 1995,0085,58, Novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds.
26 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
27 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
28 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
29 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
30 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
31 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
32 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
33 Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45.
34 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
35 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
36 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
37 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
38 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
39 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
40 FDA Drug Development and Drug Interactions
41 Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.
42 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
43 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.20)
44 Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP. J Pharm Sci. 2017 Sep;106(9):2688-2694.
45 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
46 Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45.
47 Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009 May;37(5):1129-37.
48 pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm. 2011 Aug 1;8(4):1303-13.
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