Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQVRZH)

Drug Name
Vitamin B3 Drug Info
Synonyms Niacin (TN); Niacinamide (TN); Nicotinamide (TN)
Indication
Disease Entry ICD 11 Status REF
Chronic renal failure GB61.Z Approved [1]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia 5C80.Z Approved [3]
Hyperlipidemia, familial combined, LPL related Approved [4]
Hypertriglyceridemia 5C80.1 Approved [5]
Lipid metabolism disorder 5C52.Z Approved [6]
Primary hypercholesterolemia 5C80.00 Approved [7]
Psoriasis EA90 Approved [8]
Vitamin deficiency 5B55-5B71 Approved [9]
Cross-matching ID
PubChem CID
938
ChEBI ID
CHEMBL15940
CAS Number
CAS 59-67-6
TTD Drug ID
DMQVRZH
INTEDE Drug ID
DR2115
ACDINA Drug ID
D00466

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nicotinic acid receptor (HCAR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARI-3037MO DM9LNXS Cardiovascular disease BA00-BE2Z Phase 2 [18]
SCH-900271 DMBJY1Z Ischemic stroke 8B11.5Z Phase 2 [19]
GSK-256073 DMMAIY2 Hyperlipidaemia 5C80 Phase 2 [20]
MK-1903 DMVJB09 Arteriosclerosis BD40 Phase 2 [21]
MK-0354 DMWFTRJ N. A. N. A. Phase 2 [22]
NIA-114 DM3ADQW Plaque psoriasis EA90.0 Clinical trial [23]
INCB19602 DMRHZBD Type-2 diabetes 5A11 Discontinued in Phase 2 [24]
cinnamic acid DM340FH Discovery agent N.A. Investigative [25]
5-Benzyl-1H-pyrazole-3-carboxylic acid DMJVGUZ Discovery agent N.A. Investigative [26]
Sazetidine-A DM68JI5 Major depressive disorder 6A70.3 Investigative [19]
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Drug(s) Targeting Diacylglycerol O-acyltransferase 2 (DGAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARI-3037MO DM9LNXS Cardiovascular disease BA00-BE2Z Phase 2 [27]
PF-06865571 DMZE3GK Non-alcoholic steatohepatitis DB92.1 Phase 2 [28]
PF-06427878 DMGB32Z Cardiovascular disease BA00-BE2Z Phase 1 [18]
PMID25470667-Compound-Figure4-1A DMMVQW8 N. A. N. A. Patented [29]
PMID25470667-Compound-roselipins DMCF2G7 N. A. N. A. Patented [29]
Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [35]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [39]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Fluoxetine DM3PD2C Bipolar depression Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [49]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [43]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [54]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [55]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
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Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Etretinate DM2CZFA Keratosis ED56 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [65]
Ethanol DMDRQZU Chronic pain MG30 Approved [66]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [62]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [72]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [35]
Leflunomide DMR8ONJ Arthritis FA20 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [65]
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Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
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Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Panobinostat DM58WKG Chronic graft versus host disease Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Testosterone enanthate DMB6871 N. A. N. A. Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Capsaicin DMGMF6V Back pain ME84.Z Approved [96]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [97]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [101]
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Drug(s) Affected By Long-chain fatty acid transport protein 4 (SLC27A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [65]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [107]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [108]
Milchsaure DM462BT Pruritus EC90 Investigative [109]
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Drug(s) Affected By Resistin (RETN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [112]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [113]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [114]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [115]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [116]
isobutylmethylxanthine DM46F5X Discovery agent N.A. Investigative [117]
Icosapentum DMF1CM7 N. A. N. A. Investigative [118]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [119]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Fructose DM43AN2 Vomiting MD90 Approved [120]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [121]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [124]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [125]
Leflunomide DMR8ONJ Arthritis FA20 Approved [79]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [125]
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Drug(s) Affected By NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [127]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [98]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [129]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [85]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [130]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Diacylglycerol O-acyltransferase 2 (DGAT2) TTRHEQ4 DGAT2_HUMAN Inhibitor [6]
Nicotinic acid receptor (HCAR2) TTWNV8U HCAR2_HUMAN Agonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cyclic ADP-ribose hydrolase 1 (CD38) Main DME DEGF70S CD38_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Gene/Protein Processing [11]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Gene/Protein Processing [12]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [13]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [14]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Gene/Protein Processing [15]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Gene/Protein Processing [15]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Gene/Protein Processing [15]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Gene/Protein Processing [16]
Long-chain fatty acid transport protein 4 (SLC27A4) OTWT4HAF S27A4_HUMAN Gene/Protein Processing [16]
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4) OT5S0J23 SIR4_HUMAN Gene/Protein Processing [17]

References

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2 Vitamin B3 impairs reverse cholesterol transport in Apolipoprotein E-deficient mice. Clin Investig Arterioscler. 2019 Nov-Dec;31(6):251-260.
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6 Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE: The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31.
7 Extended-release niacin (nicotinic acid)/laropiprant. Drugs. 2009 Aug 20;69(12):1665-79.
8 Cosmeceutical Aptitudes of Niacinamide: A Review. Recent Adv Antiinfect Drug Discov. 2021;16(3):196-208.
9 Hydrosoluble vitamins. Handb Clin Neurol. 2014;120:891-914.
10 ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP. J Biol Chem. 1995 Dec 22;270(51):30327-33.
11 Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E120-7. doi: 10.1152/ajpendo.00542.2003. Epub 2004 Jan 28.
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13 Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis. 2009 Jan;202(1):68-75. doi: 10.1016/j.atherosclerosis.2008.04.044. Epub 2008 May 9.
14 Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. Am J Cardiol. 2006 Sep 15;98(6):743-5. doi: 10.1016/j.amjcard.2006.04.011. Epub 2006 Jul 26.
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18 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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20 GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2013 Nov;15(11):1013-21.
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23 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
24 DOI: 10.1038/scibx.2010.313
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36 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
37 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
38 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
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42 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
43 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
44 Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
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46 Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
47 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
48 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
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52 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
53 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
54 The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
55 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
56 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
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