Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQVRZH)

• Drug Name: Vitamin B3 Drug Info
• Synonyms: Niacin (TN); Niacinamide (TN); Nicotinamide (TN)

Indication

Disease Entry	ICD 11	Status	REF
Chronic renal failure	GB61.Z	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[3]
Hyperlipidemia, familial combined, LPL related		Approved	[4]
Hypertriglyceridemia	5C80.1	Approved	[5]
Lipid metabolism disorder	5C52.Z	Approved	[6]
Primary hypercholesterolemia	5C80.00	Approved	[7]
Psoriasis	EA90	Approved	[8]
Vitamin deficiency	5B55-5B71	Approved	[9]

• Cross-matching ID:
  PubChem CID: 938
  ChEBI ID: CHEBI:15940
  CAS Number: CAS 59-67-6
  TTD Drug ID: DMQVRZH
  INTEDE Drug ID: DR2115
  ACDINA Drug ID: D00466

Molecule-Related Drug Atlas

Drug(s) Targeting Nicotinic acid receptor (HCAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARI-3037MO	DM9LNXS	Cardiovascular disease	BA00-BE2Z	Phase 2	[18]
SCH-900271	DMBJY1Z	Ischemic stroke	8B11.5Z	Phase 2	[19]
GSK-256073	DMMAIY2	Hyperlipidaemia	5C80	Phase 2	[20]
MK-1903	DMVJB09	Arteriosclerosis	BD40	Phase 2	[21]
MK-0354	DMWFTRJ	N. A.	N. A.	Phase 2	[22]
NIA-114	DM3ADQW	Plaque psoriasis	EA90.0	Clinical trial	[23]
INCB19602	DMRHZBD	Type-2 diabetes	5A11	Discontinued in Phase 2	[24]
cinnamic acid	DM340FH	Discovery agent	N.A.	Investigative	[25]
5-Benzyl-1H-pyrazole-3-carboxylic acid	DMJVGUZ	Discovery agent	N.A.	Investigative	[26]
Sazetidine-A	DM68JI5	Major depressive disorder	6A70.3	Investigative	[19]

Drug(s) Targeting Diacylglycerol O-acyltransferase 2 (DGAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARI-3037MO	DM9LNXS	Cardiovascular disease	BA00-BE2Z	Phase 2	[27]
PF-06865571	DMZE3GK	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[28]
PF-06427878	DMGB32Z	Cardiovascular disease	BA00-BE2Z	Phase 1	[18]
PMID25470667-Compound-Figure4-1A	DMMVQW8	N. A.	N. A.	Patented	[29]
PMID25470667-Compound-roselipins	DMCF2G7	N. A.	N. A.	Patented	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[219]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[39]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[42]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[53]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[57]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[58]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[59]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[62]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[63]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[64]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[67]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[71]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[72]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[72]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[77]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[78]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[79]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[85]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]

Drug(s) Affected By Apolipoprotein(a) (LPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[95]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[105]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[106]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[107]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[109]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[110]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[105]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[121]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[122]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[128]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[131]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[132]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[90]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[138]

Drug(s) Affected By Hydroxycarboxylic acid receptor 3 (HCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[153]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[167]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[170]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[171]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[171]

Drug(s) Affected By Hormone-sensitive lipase (LIPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[173]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[170]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[174]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[176]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[131]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Platelet-activating factor acetylhydrolase (PLA2G7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[183]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[183]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[186]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[187]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[189]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[190]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[189]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[191]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[193]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[194]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[90]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[90]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[90]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]

Drug(s) Affected By Long-chain fatty acid transport protein 4 (SLC27A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[203]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[204]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[207]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[208]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[211]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[212]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[215]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[216]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By Resistin (RETN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[138]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[222]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[224]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[225]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[226]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[227]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Fructose	DM43AN2	Vomiting	MD90	Approved	[228]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[229]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[232]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[116]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[233]

Drug(s) Affected By NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[238]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol O-acyltransferase 2 (DGAT2)	TTRHEQ4	DGAT2_HUMAN	Inhibitor	[6]
Nicotinic acid receptor (HCAR2)	TTWNV8U	HCAR2_HUMAN	Agonist	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cyclic ADP-ribose hydrolase 1 (CD38) Main DME	DEGF70S	CD38_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Gene/Protein Processing	[11]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[12]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[13]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[13]
Apolipoprotein(a) (LPA)	OTRZLU9F	APOA_HUMAN	Gene/Protein Processing	[14]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Gene/Protein Processing	[15]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[16]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Gene/Protein Processing	[17]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Gene/Protein Processing	[12]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Gene/Protein Processing	[12]

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