Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRBVHE)

Drug Name
GSK690693 Drug Info
Synonyms
937174-76-0; GSK690693; GSK-690693; GSK 690693; UNII-GWH480321B; (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol; CHEBI:90677; GWH480321B; 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol; 4-{2-(4-Amino-1,2,5-Oxadiazol-3-Yl)-1-Ethyl-7-[(3s)-Piperidin-3-Ylmethoxy]-1h-Imidazo[4,5-C]pyridin-4-Yl}-2-Methylbut-3-Yn-2-Ol; J-502225; C21H27N7O3
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Phase 1 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
16725726
ChEBI ID
CHEBI:90677
CAS Number
CAS 937174-76-0
TTD Drug ID
DMRBVHE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [7]
ARQ 092 DM5WK0J Proteus syndrome LD2C Phase 2 [8]
MK-2206 DMT1OZ6 Rectal adenocarcinoma 2B92 Phase 2 [9]
GSK2141795 DMSHE70 Colorectal cancer 2B91.Z Phase 2 [10]
M2698 DM3PVBJ Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
LYS-6KAKT1 DMLXGAI Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
LY2780301 DM93AJW Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
XL418 DME0F5W Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
SR13668 DMO5760 Solid tumour/cancer 2A00-2F9Z Phase 1 [15]
TCN-P DMV0AH8 Acute myeloid leukaemia 2A60 Phase 1 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [21]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [22]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Leflunomide DMR8ONJ Arthritis FA20 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [27]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [28]
Fructose DM43AN2 Vomiting MD90 Approved [29]
Ketoprofen DMRKXPT Bursitis Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [31]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Epinephrine DM3KJBC Acute asthma CA23 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Fructose DM43AN2 Vomiting MD90 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [44]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [45]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [52]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [53]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
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Drug(s) Affected By Tuberin (TSC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [60]
Methamphetamine DMPM4SK Anxiety Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [63]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [72]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [84]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [86]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-gamma serine/threonine-protein kinase (AKT3) TTAZ05C AKT3_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [3]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [4]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Post-Translational Modifications [3]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Post-Translational Modifications [5]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [6]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Post-Translational Modifications [4]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Protein Interaction/Cellular Processes [6]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Protein Interaction/Cellular Processes [6]

References

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71 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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78 Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
79 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
80 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
81 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
82 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
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