Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRBVHE)

Drug Name

GSK690693 Drug Info

Synonyms

937174-76-0; GSK690693; GSK-690693; GSK 690693; UNII-GWH480321B; (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol; CHEBI:90677; GWH480321B; 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol; 4-{2-(4-Amino-1,2,5-Oxadiazol-3-Yl)-1-Ethyl-7-[(3s)-Piperidin-3-Ylmethoxy]-1h-Imidazo[4,5-C]pyridin-4-Yl}-2-Methylbut-3-Yn-2-Ol; J-502225; C21H27N7O3

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 16725726
ChEBI ID: CHEMBL90677
CAS Number: CAS 937174-76-0
TTD Drug ID: DMRBVHE

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting RAC-gamma serine/threonine-protein kinase (AKT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[6]
ARQ 092	DM5WK0J	Proteus syndrome	LD2C	Phase 2	[7]
MK-2206	DMT1OZ6	Rectal adenocarcinoma	2B92	Phase 2	[8]
GSK2141795	DMSHE70	Colorectal cancer	2B91.Z	Phase 2	[9]
M2698	DM3PVBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
LYS-6KAKT1	DMLXGAI	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
LY2780301	DM93AJW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
XL418	DME0F5W	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
SR13668	DMO5760	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]
TCN-P	DMV0AH8	Acute myeloid leukaemia	2A60	Phase 1	[15]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[21]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Fructose	DM43AN2	Vomiting	MD90	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[34]
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Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[41]
Methamphetamine	DMPM4SK	Anxiety		Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[44]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[50]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
RAC-gamma serine/threonine-protein kinase (AKT3)	TTAZ05C	AKT3_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[3]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Post-Translational Modifications	[3]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Post-Translational Modifications	[4]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Protein Interaction/Cellular Processes	[5]

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References

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