Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT1OZ6)

Drug Name
MK-2206 Drug Info
Synonyms
MK-2206; 1032349-93-1; UNII-51HZG6MP1K; MK 2206; 51HZG6MP1K; CHEMBL1079175; CHEBI:67271; NCGC00186465-01; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one; DSSTox_RID_83143; DSSTox_CID_28874; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; DSSTox_GSID_48948; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; 1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-;
Indication
Disease Entry ICD 11 Status REF
Rectal adenocarcinoma 2B92 Phase 2 [1]
Nasopharyngeal carcinoma 2B6B Investigative [2]
Cross-matching ID
PubChem CID
24964624
ChEBI ID
CHEMBL67271
CAS Number
CAS 1032349-93-1
TTD Drug ID
DMT1OZ6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [10]
ARQ 092 DM5WK0J Proteus syndrome LD2C Phase 2 [11]
GSK2141795 DMSHE70 Colorectal cancer 2B91.Z Phase 2 [12]
M2698 DM3PVBJ Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
LYS-6KAKT1 DMLXGAI Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
LY2780301 DM93AJW Solid tumour/cancer 2A00-2F9Z Phase 1 [15]
XL418 DME0F5W Solid tumour/cancer 2A00-2F9Z Phase 1 [16]
SR13668 DMO5760 Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
TCN-P DMV0AH8 Acute myeloid leukaemia 2A60 Phase 1 [18]
GSK690693 DMRBVHE Haematological malignancy 2B33.Y Phase 1 [19]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
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Drug(s) Affected By Endothelin receptor type B (EDNRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Testosterone enanthate DMB6871 N. A. N. A. Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [36]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [37]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [38]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Epinephrine DM3KJBC Acute asthma CA23 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Fructose DM43AN2 Vomiting MD90 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [47]
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Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [52]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [53]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [54]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [53]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [55]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [56]
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Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [63]
Testosterone DM7HUNW Hot flushes GA30 Approved [72]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [76]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [80]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [81]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
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Drug(s) Affected By Interferon regulatory factor 8 (IRF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [86]
Arsenic DMTL2Y1 N. A. N. A. Approved [87]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [88]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [89]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [90]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [91]
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Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [92]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [96]
Cabazitaxel DMPAZHC Breast cancer 2C60-2C65 Approved [97]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [98]
Urethane DM7NSI0 N. A. N. A. Phase 4 [99]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E2 ubiquitin-conjugating enzyme T (UBE2T) TT0A1R8 UBE2T_HUMAN Inhibitor [2]
RAC-gamma serine/threonine-protein kinase (AKT3) TTAZ05C AKT3_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [4]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Gene/Protein Processing [5]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Gene/Protein Processing [5]
Interferon regulatory factor 8 (IRF8) OT8YSNI4 IRF8_HUMAN Gene/Protein Processing [5]
Proline-rich AKT1 substrate 1 (AKT1S1) OT4JHN4Y AKTS1_HUMAN Post-Translational Modifications [6]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Gene/Protein Processing [7]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [8]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Gene/Protein Processing [5]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Protein Interaction/Cellular Processes [9]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [5]

References

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34 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
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36 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
37 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
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40 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
41 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
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57 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
58 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
59 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
60 C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation. Cell Signal. 2006 Jul;18(7):955-63. doi: 10.1016/j.cellsig.2005.08.014. Epub 2005 Oct 14.
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63 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
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65 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
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67 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
68 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
69 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
70 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
71 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
72 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
73 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
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75 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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