Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVRLT7)

Drug Name

Fludarabine Drug Info

Synonyms

FaraA; Fludarabina; Fludarabinum; Fluradosa; Fludarabina [Spanish]; Fludarabine [INN]; Fludarabinum [Latin]; SQ Fludarabine; Fludara, Fludarabine; Fludarabine (INN); Fluradosa (TN); F-Ara-A; (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-F-ara-A; 2-Fluoro Ara-A; 2-Fluoro-9-beta-D-arabinofuranosyladenine; 9-beta-D-Arabinofuranosyl-2-fluoroadenine; 9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine; 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro-(9CI)

Indication

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[1]
Cutaneous melanoma	2C30	Approved	[1]
Haematological malignancy	2B33.Y	Approved	[2]
Hematologic disease	3C0Z	Approved	[1]
Hepatosplenic T-cell lymphoma		Approved	[1]
Immunodeficiency	4A00-4A85	Approved	[1]
Large granular lymphocytic leukemia	2A90.1	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
MALT lymphoma		Approved	[1]
Multiple sclerosis	8A40	Approved	[1]
Myeloproliferative neoplasm	2A20	Approved	[1]
Nodal marginal zone lymphoma	2A85.0	Approved	[1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified		Approved	[1]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[1]
Small intestine lymphoma		Approved	[1]
Splenic marginal zone lymphoma		Approved	[1]
Systemic lupus erythematosus	4A40.0	Approved	[1]
Systemic sclerosis	4A42	Approved	[1]
Testicular lymphoma		Approved	[1]
Classic Hodgkin lymphoma		Investigative	[1]
Colon cancer	2B90.Z	Investigative	[1]
Gastric cancer	2B72	Investigative	[1]
Neuroblastoma	2D11.2	Investigative	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 657237
ChEBI ID: CHEMBL1568
CAS Number: CAS 21679-14-1
TTD Drug ID: DMVRLT7
VARIDT Drug ID: DR00434

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[13]
Elapegademase	DMS7OU8	Adenosine deaminase defciency	4A01.1	Approved	[14]
Pentostatin	DM0HXDS	Acute graft versus host disease	4B24.0	Approved	[3]
GSK2696273	DMP5O1U	Chronic pain	MG30	Preregistration	[15]
OTL-101	DMLMS6J	Severe combined immunodeficiency	4A01.10	Phase 3	[16]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy	DMIREUZ	Immunodeficiency	4A00-4A85	Phase 1/2	[15]
EHNA	DM014WS	Discovery agent	N.A.	Investigative	[17]
3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol	DMZT8QX	Discovery agent	N.A.	Investigative	[18]
3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol	DMAIS1D	Discovery agent	N.A.	Investigative	[18]
1-Deaza-Adenosine	DMG0VN6	Discovery agent	N.A.	Investigative	[19]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[24]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[27]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[36]
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Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[41]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Fructose	DM43AN2	Vomiting	MD90	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[56]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[60]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[61]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[68]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[69]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[60]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[61]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[75]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[77]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[78]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[30]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[98]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[99]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[6]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[7]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[8]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Gene/Protein Processing	[9]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Gene/Protein Processing	[10]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[11]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Gene/Protein Processing	[12]

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