Details of Disease

Disease Name

Basal cell neoplasm

neoplasm, basal cell; basal cell tumour; basal cell tumor

Definition

A neoplastic proliferation of basal cells in the epidermis (part of the skin) or other anatomic sites (most frequently the salivary glands). The basal cell neoplastic proliferation in the epidermis results in basal cell carcinomas. The basal cell neoplastic proliferation in the salivary glands can be benign, resulting in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas.

Disease Hierarchy

DIS0T594: Epithelial neoplasm

DISTBY9Z: Tumour

DIS37IXW: Basal cell neoplasm

Disease Identifiers

MONDO ID

MONDO_0020799

MESH ID

D018295

UMLS CUI

C0206710

MedGen ID

104921

SNOMED CT ID

127570002

General Information of Disease (ID: DIS37IXW)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CTSH	TT3G406	Limited	Genetic Variation	[1]
CTSS	TTUMQVO	Limited	Genetic Variation	[1]
CYP1B1	TTI84H7	Limited	Genetic Variation	[1]
FOXP1	TT0MUCI	Limited	Genetic Variation	[1]
GPR183	TTME5YJ	Limited	Genetic Variation	[1]
HAL	TTXQOZW	Limited	Genetic Variation	[1]
MC1R	TT0MV2T	Limited	Genetic Variation	[1]
PPARGC1B	TTKSQ3W	Limited	Genetic Variation	[1]
RAC1	TT2M9CG	Limited	Genetic Variation	[1]
SLC6A17	TTIMLZ6	Limited	Genetic Variation	[1]
SMC2	TTS8D17	Limited	Genetic Variation	[1]
TYR	TTULVH8	Limited	Genetic Variation	[1]
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⏷ Show the Full List of 12 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC45A2	DTNCJAT	Limited	Genetic Variation	[1]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
TGM3	DEOEB3Q	Limited	Genetic Variation	[1]
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This Disease Is Related to 28 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATP11A	OT7M9ZDK	Limited	Genetic Variation	[1]
BACH2	OT17GS18	Limited	Genetic Variation	[1]
CCDC88B	OTEDUI2J	Limited	Genetic Variation	[1]
CLPTM1L	OTDJWQXI	Limited	Genetic Variation	[1]
COLEC10	OTMBADGZ	Limited	Genetic Variation	[1]
CPVL	OTOJL31C	Limited	Genetic Variation	[1]
EFEMP2	OT0I2B4J	Limited	Genetic Variation	[1]
EXO1	OTI87RS5	Limited	Genetic Variation	[1]
FLACC1	OTZN9TZV	Limited	Genetic Variation	[1]
FRMD4A	OTJDTIK2	Limited	Genetic Variation	[1]
GPX4	OTRAFFX2	Limited	Genetic Variation	[1]
HAUS6	OT7ZVR57	Limited	Genetic Variation	[1]
HERC2	OTNQYKOB	Limited	Genetic Variation	[1]
IRF4	OT1DHQ1P	Limited	Genetic Variation	[1]
JDP2	OTW35WKX	Limited	Genetic Variation	[1]
KANK1	OT2E7A6W	Limited	Genetic Variation	[1]
KRT5	OTVGI9HT	Limited	Genetic Variation	[1]
LPP	OT6TU8SE	Limited	Genetic Variation	[1]
PADI6	OTS42I3K	Limited	Genetic Variation	[2]
PTPN22	OTDCNTC3	Limited	Genetic Variation	[1]
RALY	OT78NNWY	Limited	Genetic Variation	[1]
RCC2	OTUJVTLS	Limited	Genetic Variation	[1]
RGS22	OTCTFGW6	Limited	Genetic Variation	[1]
SCAF1	OT16TM3N	Limited	Genetic Variation	[1]
STN1	OT8UWRA3	Limited	Genetic Variation	[1]
TNS3	OTPG2D8Z	Limited	Genetic Variation	[1]
TRPS1	OT7XPPEL	Limited	Genetic Variation	[1]
PTCH1	OTMG07H5	Definitive	Biomarker	[3]
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⏷ Show the Full List of 28 DOT(s)

References

1	Combined analysis of keratinocyte cancers identifies novel genome-wide loci.Hum Mol Genet. 2019 Sep 15;28(18):3148-3160. doi: 10.1093/hmg/ddz121.
2	New basal cell carcinoma susceptibility loci.Nat Commun. 2015 Apr 9;6:6825. doi: 10.1038/ncomms7825.
3	Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice.Nat Med. 1999 Nov;5(11):1285-91. doi: 10.1038/15242.