Details of Disease

Disease Name

Intracerebral hemorrhage

stroke, hemorrhagic

Definition

Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma.

Disease Hierarchy

DISAB237: Cerebrovascular disease

DISC81BT: Intracerebral hemorrhage

Disease Identifiers

MONDO ID

MONDO_0013792

MESH ID

D002543

UMLS CUI

C2937358

MedGen ID

423648

HPO ID

HP:0001342

SNOMED CT ID

274100004

General Information of Disease (ID: DISC81BT)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chlorhexidine	DMQ9MVG	Approved	Small molecular drug	[1]
Fluoxetine	DM3PD2C	Approved	Small molecular drug	[2]
Nicardipine	DMCDYW7	Approved	Small molecular drug	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 40 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACE	TTL69WB	Limited	Unknown	[4]
ANXA1	TTUCK4B	Limited	Biomarker	[5]
APEX1	TTHGL48	Limited	Biomarker	[6]
C3	TTJGY7A	Limited	Biomarker	[7]
MMP12	TTXZ0KQ	Limited	Biomarker	[8]
NPY	TT64REZ	Limited	Biomarker	[9]
BECN1	TT5M7LN	moderate	Biomarker	[10]
CASP9	TTB6T7O	moderate	Therapeutic	[11]
CD14	TT6I7DC	moderate	Biomarker	[12]
CXCR4	TTBID49	moderate	Therapeutic	[13]
DAG1	TT4X7PG	moderate	Biomarker	[14]
NFKB1	TTUIZKC	moderate	Biomarker	[15]
NFKB2	TTKLNRV	moderate	Biomarker	[15]
NFKBIA	TTSHAEB	moderate	Biomarker	[16]
NQO1	TT8XK6L	moderate	Therapeutic	[17]
SLC8B1	TTJN46R	moderate	Biomarker	[18]
SQSTM1	TTOT2RY	moderate	Biomarker	[10]
THBS1	TTKI0H1	moderate	Biomarker	[19]
APP	TTE4KHA	Strong	Genetic Variation	[20]
BAX	TTQ57WJ	Strong	Biomarker	[21]
BCL2L1	TTRE6AX	Strong	Biomarker	[21]
CASP3	TTPF2QI	Strong	Therapeutic	[11]
CASP8	TT6SZNG	Strong	Therapeutic	[11]
CNTF	TTGEM5Q	Strong	Therapeutic	[22]
FLT1	TT1VAUK	Strong	Biomarker	[23]
HMOX2	TTWZRL4	Strong	Therapeutic	[24]
IL1RN	TT6GSR3	Strong	Biomarker	[25]
ITGAV	TTT1R2L	Strong	Biomarker	[26]
ITGB3	TTJA1ZO	Strong	Biomarker	[26]
KDR	TTUTJGQ	Strong	Biomarker	[23]
MMP2	TTLM12X	Strong	Biomarker	[27]
MMP3	TTUZ2L5	Strong	Biomarker	[28]
NPPB	TTY63XT	Strong	Therapeutic	[29]
PLAT	TTXAGYU	Strong	Biomarker	[30]
PLAU	TTGY7WI	Strong	Biomarker	[31]
S100B	TTQ0V86	Strong	Biomarker	[32]
SERPINC1	TT4QPUL	Strong	Biomarker	[33]
SPP1	TT8ME6I	Strong	Therapeutic	[34]
TUBB1	TT63KYR	Strong	Genetic Variation	[35]
F7	TTF0EGX	Definitive	Therapeutic	[36]
------------------------------------------------------------------------------------


⏷ Show the Full List of 40 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC24A1	DTJZ7M5	moderate	Biomarker	[18]
------------------------------------------------------------------------------------

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MT1A	DE5ME8A	Limited	Biomarker	[5]
MT2A	DEFKGT7	Limited	Biomarker	[5]
------------------------------------------------------------------------------------

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACE	OTDF1964	Limited	Unknown	[4]
AQP4	OTA9MYD5	moderate	Biomarker	[14]
BNIP3L	OTJKOMXE	moderate	Biomarker	[37]
CASP12	OTY2W6FG	moderate	Therapeutic	[38]
DCX	OTISR7K3	moderate	Biomarker	[39]
MAP1LC3A	OTPMGIU4	moderate	Biomarker	[10]
RELA	OTUJP9CN	moderate	Biomarker	[15]
RELB	OTU3QYEF	moderate	Biomarker	[15]
THBS2	OTXET551	moderate	Biomarker	[19]
CST3	OTNZ6AO4	Strong	Biomarker	[40]
ITGA2B	OT4Y17PY	Strong	Biomarker	[26]
PARVB	OT9OGVWX	Strong	Genetic Variation	[41]
PMF1	OT8PQPZ1	Strong	Genetic Variation	[42]
SERPINA3	OT9BP2S0	Strong	Genetic Variation	[43]
SLC25A44	OTHHPC3C	Strong	Genetic Variation	[42]
------------------------------------------------------------------------------------


⏷ Show the Full List of 15 DOT(s)

References

1	Chlorhexidine FDA Label
2	Fluoxetine FDA Label
3	Nicardipine FDA Label
4	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
5	Brain genomics of intracerebral hemorrhage.J Cereb Blood Flow Metab. 2006 Feb;26(2):230-52. doi: 10.1038/sj.jcbfm.9600183.
6	Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage.Neurosurg Focus. 2003 Oct 15;15(4):ECP4. doi: 10.3171/foc.2003.15.4.10.
7	Brain edema after intracerebral hemorrhage in rats: the role of inflammation.Neurol India. 2006 Dec;54(4):402-7. doi: 10.4103/0028-3886.28115.
8	Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases.Ann Neurol. 2003 Jun;53(6):731-42. doi: 10.1002/ana.10553.
9	[Changes of neuropeptide Y activity in plasma and brain tissue during intracerebral hemorrhage in rats].Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Apr;16(4):218-20.
10	Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage.Neurosci Bull. 2014 Feb;30(1):90-8. doi: 10.1007/s12264-013-1371-6. Epub 2013 Jul 25.
11	The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH).Neuropsychiatr Dis Treat. 2016 Dec 28;13:77-85. doi: 10.2147/NDT.S120496. eCollection 2017.
12	Increased serum endotoxin and elevated CD14 and IL-1beta expression in a rat model of cerebrogenic multiple organ dysfunction syndrome.Med Chem. 2009 Sep;5(5):462-7. doi: 10.2174/157340609789117903. Epub 2009 Sep 1.
13	The effect of CXCL12 on endothelial progenitor cells: potential target for angiogenesis in intracerebral hemorrhage.J Interferon Cytokine Res. 2015 Jan;35(1):23-31. doi: 10.1089/jir.2014.0004. Epub 2014 Jun 23.
14	Loss of AQP4 polarized localization with loss of -dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage.Neurosci Lett. 2015 Feb 19;588:42-8. doi: 10.1016/j.neulet.2014.12.053. Epub 2014 Dec 27.
15	Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression.J Neurochem. 2007 May;101(3):652-63. doi: 10.1111/j.1471-4159.2006.04414.x. Epub 2007 Jan 23.
16	Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats.Mediators Inflamm. 2009;2009:473276. doi: 10.1155/2009/473276. Epub 2010 Jan 31.
17	MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.Oncotarget. 2017 Aug 7;8(41):70669-70684. doi: 10.18632/oncotarget.19974. eCollection 2017 Sep 19.
18	Alteration of intracellular calcium and its modulator SLC24A6 after experimental intracerebral hemorrhage.Acta Neurochir Suppl. 2013;118:169-73. doi: 10.1007/978-3-7091-1434-6_31.
19	Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Laboratory investigation.J Neurosurg. 2010 Oct;113(4):820-5. doi: 10.3171/2010.1.JNS09637.
20	[Recurrent intraparenchimal haemorrhages in a patient with cerebral amyloidotic angiopathy: description of one autopsy case].Pathologica. 2006 Feb;98(1):44-7.
21	Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats.Proc Natl Acad Sci U S A. 2003 May 13;100(10):6087-92. doi: 10.1073/pnas.1031632100. Epub 2003 Apr 29.
22	Intracerebral infusion of a second-generation ciliary neurotrophic factor reduces neuronal loss in rat striatum following experimental intracerebral hemorrhage.J Neurol Sci. 2001 Nov 15;192(1-2):53-9. doi: 10.1016/s0022-510x(01)00605-0.
23	Cerebral angiogenesis after collagenase-induced intracerebral hemorrhage in rats.Brain Res. 2007 Oct 17;1175:134-42. doi: 10.1016/j.brainres.2007.08.028. Epub 2007 Aug 19.
24	Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage.Neurobiol Dis. 2006 Jun;22(3):473-6. doi: 10.1016/j.nbd.2005.12.009. Epub 2006 Feb 3.
25	Age-related comparisons of evolution of the inflammatory response after intracerebral hemorrhage in rats.Transl Stroke Res. 2012 Jul;3(Suppl 1):132-46. doi: 10.1007/s12975-012-0151-3. Epub 2012 Mar 16.
26	Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.Stroke. 1998 Jan;29(1):235-8. doi: 10.1161/01.str.29.1.235.
27	Evidence for apoptosis after intercerebral hemorrhage in rat striatum.J Cereb Blood Flow Metab. 2000 Feb;20(2):396-404. doi: 10.1097/00004647-200002000-00022.
28	Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse.J Cereb Blood Flow Metab. 2008 Apr;28(4):752-63. doi: 10.1038/sj.jcbfm.9600572. Epub 2007 Oct 31.
29	Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.J Neurotrauma. 2010 Jan;27(1):217-28. doi: 10.1089/neu.2009.1022.
30	Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry.Cerebrovasc Dis. 2011;31(2):123-9. doi: 10.1159/000321516. Epub 2010 Nov 17.
31	Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan.Stroke. 2007 Oct;38(10):2633-9. doi: 10.1161/STROKEAHA.107.488551. Epub 2007 Aug 16.
32	Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke.Brain Res Bull. 2009 Mar 16;78(4-5):158-63. doi: 10.1016/j.brainresbull.2008.10.012. Epub 2008 Nov 21.
33	Changes of the levels of antithrombin III in patients with cerebrovascular diseases.Thromb Res. 1983 Jul 15;31(2):197-202. doi: 10.1016/0049-3848(83)90321-3.
34	Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice.Neurocrit Care. 2011 Feb;14(1):109-17. doi: 10.1007/s12028-010-9372-z.
35	The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men.Haematologica. 2007 Apr;92(4):513-8. doi: 10.3324/haematol.10689.
36	Comparative effectiveness of hemostatic therapy in experimental warfarin-associated intracerebral hemorrhage.Stroke. 2011 Jan;42(1):191-5. doi: 10.1161/STROKEAHA.110.593541. Epub 2010 Dec 2.
37	Up-regulated expression of Bnip3L after intracerebral hemorrhage in adult rats.J Mol Histol. 2013 Oct;44(5):497-505. doi: 10.1007/s10735-013-9506-7. Epub 2013 Jun 15.
38	Roles of autophagy and endoplasmic reticulum stress in intracerebral hemorrhage-induced secondary brain injury inrats.CNS Neurosci Ther. 2017 Jul;23(7):554-566. doi: 10.1111/cns.12703. Epub 2017 May 19.
39	[Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage].Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1437-41.
40	The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models.Brain Pathol. 2006 Jan;16(1):60-70. doi: 10.1111/j.1750-3639.2006.tb00562.x.
41	17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage.Stroke. 2018 Jul;49(7):1618-1625. doi: 10.1161/STROKEAHA.117.020091. Epub 2018 Jun 18.
42	Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012. Epub 2014 Mar 20.
43	Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage.Eur Neurol. 2008;59(6):307-14. doi: 10.1159/000121420. Epub 2008 Apr 11.