Details of Disease

General Information of Disease (ID: DISQUCTY)

• Disease Name: Zika virus infection
• Synonyms: Zika fever; fever, Zika; congenital Zika syndrome; congenital Zika virus infection; Zika virus infectious disease; ZikV infection; Zika; Zika virus disease; Zika virus disease or disorder; Zika virus caused disease or disorder; Zika virus infection
• Disease Class: 1D48: Zika virus infection
• Definition: Mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy.
• Disease Hierarchy:
  DISGFCIX: Vector-borne disease
  DISUDW4N: Flaviviridae infectious disease
  DISEM33Q: Infectious disease
  DISQUCTY: Zika virus infection
• ICD Code: ICD-11: ICD-11: 1D48
• Disease Identifiers:
  MONDO ID: MONDO_0018661
  MESH ID: D000071243
  UMLS CUI: C0276289
  MedGen ID: 547236
  Orphanet ID: 448237
  SNOMED CT ID: 3928002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
INO-4600	DM2LD54	Phase 1	Vaccine	[1]
INO-A002	DMD289H	Phase 1	Antibody	[2]
JNJ-66684657	DMGV48B	Phase 1	Vaccine	[3]
mRNA-1893	DMKRYPU	Phase 1	Vaccine	[4]
TAK-426	DMKZ6U2	Phase 1	Vaccine	[5]
VLA1601	DM10PLO	Phase 1	Vaccine	[6]
ZIKV-IG	DMSQ8ED	Phase 1	Vaccine	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 14 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALDH5A1	TTJUWVB	Strong	Altered Expression	[8]
DDX58	TTVB0O3	Strong	Biomarker	[9]
EIF5A	TTIVCNR	Strong	Biomarker	[10]
G3BP1	TTG0R8Z	Strong	Biomarker	[11]
GNE	TT4DP5S	Strong	Biomarker	[12]
HNRNPA2B1	TT8UPW6	Strong	Altered Expression	[13]
IFNAR1	TTSYFMA	Strong	Biomarker	[14]
IFNAR2	TTMQB37	Strong	Biomarker	[15]
IFNL1	TTM624L	Strong	Biomarker	[16]
IRF3	TTYR7OH	Strong	Biomarker	[17]
ISG15	TTVOH3T	Strong	Biomarker	[18]
LTBR	TTFO0PM	Strong	Biomarker	[19]
MAP3K11	TTETX6Q	Strong	Biomarker	[20]
TICAM1	TT2GQT6	Strong	Biomarker	[21]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SMOX	DEOH5V3	Strong	Altered Expression	[22]

This Disease Is Related to 53 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IFITM3	OT2QP8D3	Limited	Biomarker	[23]
SLFN11	OTJWFPMY	Limited	Biomarker	[24]
AP2A1	OTEFZB21	Strong	Biomarker	[25]
APOBEC3C	OTPL0AI1	Strong	Biomarker	[26]
C19orf53	OT425SIG	Strong	Altered Expression	[27]
CAPRIN1	OTEJAMS3	Strong	Biomarker	[28]
CD48	OT83ZNPP	Strong	Biomarker	[29]
CEP131	OT6PF80T	Strong	Biomarker	[30]
CH25H	OT9S2BSW	Strong	Biomarker	[31]
CHCHD2	OTL5PA3Y	Strong	Biomarker	[32]
CHML	OTW3VW8D	Strong	Altered Expression	[8]
DDX6	OTKWXVDY	Strong	Biomarker	[26]
DHX9	OT5AAOQI	Strong	Biomarker	[33]
EDC3	OTYS7O69	Strong	Biomarker	[26]
EIF4G2	OTEO98CR	Strong	Biomarker	[10]
ERVW-1	OTWV8DXJ	Strong	Biomarker	[34]
FOXD3	OTXYV6GO	Strong	Biomarker	[25]
HNRNPD	OT5UO1FA	Strong	Biomarker	[35]
HPR	OTXSC9UB	Strong	Biomarker	[36]
IFI16	OT4SPU0U	Strong	Altered Expression	[37]
IFIH1	OTZA2AHA	Strong	Biomarker	[9]
IFIT1	OTXOQDSG	Strong	Altered Expression	[38]
IFNA1	OTPMKY0L	Strong	Biomarker	[17]
IFNGR1	OTCTQBWW	Strong	Biomarker	[39]
IFNL2	OT4BMJF7	Strong	Biomarker	[16]
ITPA	OTQ47WVR	Strong	Biomarker	[40]
IVNS1ABP	OTYHL4I7	Strong	Biomarker	[41]
KPNA6	OTJ3OX6P	Strong	Biomarker	[42]
MAVS	OTTQ0J64	Strong	Biomarker	[21]
MFSD2A	OTVG1VG0	Strong	Biomarker	[43]
MOGS	OT99MBGB	Strong	Biomarker	[44]
NEURL3	OTA3ALQO	Strong	Biomarker	[45]
NTPCR	OTTRT6Z9	Strong	Biomarker	[40]
NUFIP2	OTZBZ224	Strong	Biomarker	[46]
OAS3	OT6E5FYS	Strong	Altered Expression	[47]
PAF1	OTDDGUBQ	Strong	Biomarker	[48]
PARD3	OTH5BPLO	Strong	Altered Expression	[27]
PARP12	OTCQTYIO	Strong	Altered Expression	[49]
PAX7	OTDMQRPO	Strong	Biomarker	[25]
PCM1	OTFM133C	Strong	Altered Expression	[30]
PHAX	OTSHNJ6B	Strong	Biomarker	[26]
PLAAT4	OTI66SAJ	Strong	Biomarker	[9]
PPIP5K1	OT06HYH8	Strong	Biomarker	[21]
ROBO3	OTPVG40S	Strong	Biomarker	[9]
RPE	OT0XT3JU	Strong	Biomarker	[50]
RSAD2	OTCA9WCM	Strong	Altered Expression	[51]
SART3	OTC1AM7S	Strong	Biomarker	[52]
SMPD3	OTHQBETH	Strong	Biomarker	[53]
SRL	OT7IEBWZ	Strong	Biomarker	[54]
STAT2	OTO9G2RZ	Strong	Biomarker	[41]
TAC3	OTOJGM38	Strong	Biomarker	[25]
TRIM56	OTFGU8E3	Strong	Biomarker	[55]
TRIM69	OTTEGTRD	Strong	Biomarker	[21]

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