Details of Disease

General Information of Disease (ID: DISWPO8U)

Disease Name	Eclampsia
Synonyms	postpartum eclampsia; eclampsia, postpartum; eclampsia in puerperium
Disease Class	JA25: Eclampsia
Definition	A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures.
Disease Hierarchy	DISVCIJW: Morning sickness DISWPO8U: Eclampsia
ICD Code	ICD-11 ICD-11: JA25 ICD-10 ICD-10: O15 Expand ICD-11 'JA25 Expand ICD-10 'O15
Disease Identifiers	MONDO ID MONDO_0001754 MESH ID D004461 UMLS CUI C0013537 MedGen ID 4443 HPO ID HP:0100601 SNOMED CT ID 15938005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Digoxin immune Fab	DMW3HUL	Phase 2/3	NA	[1]
Digibind	DMRJTYV	Phase 2b	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 19 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACVR2A	TTX2DRI	moderate	Genetic Variation	[3]
DUSP9	TT1GV6C	moderate	Altered Expression	[4]
FABP4	TTHWMFZ	moderate	Altered Expression	[5]
GLRX	TTRJCNG	moderate	Biomarker	[6]
ADORA2B	TTNE7KG	Strong	Posttranslational Modification	[7]
AVPR1A	TT4TFGN	Strong	Altered Expression	[8]
CUL3	TTPCU0Q	Strong	Altered Expression	[9]
CYP11B2	TT9MNE2	Strong	Genetic Variation	[10]
EDN2	TTMR0OP	Strong	Genetic Variation	[11]
FSHR	TTZFDBT	Strong	Altered Expression	[12]
FSTL3	TTWRPM8	Strong	Altered Expression	[13]
ICA1	TTMX06B	Strong	Biomarker	[14]
INHBA	TTVB30D	Strong	Genetic Variation	[15]
KIR2DL1	TT4UXPE	Strong	Genetic Variation	[16]
MTF1	TTTQDEO	Strong	Altered Expression	[17]
NECTIN4	TTPO9EG	Strong	Biomarker	[18]
PGF	TT48I1Y	Strong	Biomarker	[19]
PLAC1	TTM18HX	Strong	Biomarker	[20]
RHD	TTLCKI8	Strong	Biomarker	[21]
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⏷ Show the Full List of 19 DTT(s)

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH5	DEIOH6A	Strong	Biomarker	[22]
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This Disease Is Related to 28 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CFAP97	OT0RSQO4	Limited	Biomarker	[23]
CORIN	OT4SK7DK	Limited	Genetic Variation	[24]
TAC3	OTOJGM38	Limited	Altered Expression	[25]
AQP4	OTA9MYD5	moderate	Altered Expression	[26]
CLIC3	OT5KUZ3A	moderate	Biomarker	[27]
ERVW-1	OTWV8DXJ	moderate	Altered Expression	[28]
GCM1	OT5CPAUT	moderate	Altered Expression	[29]
PAPPA	OTTTG9PG	moderate	Genetic Variation	[30]
PSG5	OTHTU98X	moderate	Genetic Variation	[31]
C19orf33	OTOYH74A	Strong	Biomarker	[32]
CTNNA3	OT9Z0P1E	Strong	Genetic Variation	[33]
DGKI	OTDZ602D	Strong	Biomarker	[14]
EBAG9	OTTQLQCP	Strong	Altered Expression	[34]
EIF3E	OTI0WG98	Strong	Biomarker	[35]
ELF5	OTLRU8YF	Strong	Biomarker	[36]
GZMA	OT43R33L	Strong	Biomarker	[37]
HIF3A	OTPWAAMC	Strong	Posttranslational Modification	[38]
HTRA4	OT58M21J	Strong	Biomarker	[39]
IFNGR1	OTCTQBWW	Strong	Genetic Variation	[40]
IGF2BP2	OT4ZSEEE	Strong	Altered Expression	[41]
INO80B	OTSHV8JF	Strong	Genetic Variation	[42]
INTS6	OT6GDV46	Strong	Biomarker	[35]
KLRB1	OTQ2959Y	Strong	Biomarker	[43]
KLRC2	OTT4N86S	Strong	Genetic Variation	[44]
NPHS2	OTLCNUII	Strong	Altered Expression	[45]
PAPPA2	OTXYGTUZ	Strong	Altered Expression	[46]
PROK1	OT8S7RUG	Strong	Biomarker	[47]
SUMO4	OT9B447E	Strong	Biomarker	[48]
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⏷ Show the Full List of 28 DOT(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010198)
3	Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker.Cytokine. 2015 Feb;71(2):360-5. doi: 10.1016/j.cyto.2014.11.017. Epub 2014 Dec 13.
4	Dual specificity phosphatase 9 (DUSP9) expression is down-regulated in the severe pre-eclamptic placenta.Placenta. 2013 Feb;34(2):174-81. doi: 10.1016/j.placenta.2012.11.029. Epub 2012 Dec 29.
5	Study on the correlation between adipocyte fatty-acid binding protein, glucolipid metabolism, and pre-eclampsia.J Obstet Gynaecol Res. 2018 Apr;44(4):655-662. doi: 10.1111/jog.13557. Epub 2018 Jan 5.
6	Decreased expression of thioredoxin and glutaredoxin in placentae from pregnancies with pre-eclampsia and intrauterine growth restriction.Placenta. 2000 Sep;21(7):603-9. doi: 10.1053/plac.2000.0554.
7	Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation.Environ Int. 2018 Sep;118:334-347. doi: 10.1016/j.envint.2018.05.007. Epub 2018 Jun 21.
8	Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein.Clin Epigenetics. 2019 May 28;11(1):84. doi: 10.1186/s13148-019-0685-2.
9	New insights into the function of Cullin 3 in trophoblast invasion and migration.Reproduction. 2015 Aug;150(2):139-49. doi: 10.1530/REP-15-0126. Epub 2015 May 28.
10	High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.Nephrol Dial Transplant. 2009 Jun;24(6):1870-5. doi: 10.1093/ndt/gfn763. Epub 2009 Jan 16.
11	Analysis on the correlations of ENOS and ET-2 gene polymorphisms with eclampsia.Eur Rev Med Pharmacol Sci. 2019 Aug;23(16):6800-6805. doi: 10.26355/eurrev_201908_18718.
12	Reduced expression of follicle stimulating hormone receptor mRNA and protein in pregnancies complicated by preeclampsia.Mol Med Rep. 2017 Jul;16(1):367-372. doi: 10.3892/mmr.2017.6599. Epub 2017 May 18.
13	Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia.BJOG. 2007 Sep;114(9):1128-37. doi: 10.1111/j.1471-0528.2007.01425.x. Epub 2007 Jul 6.
14	Analysis of the Epigenome in Multiplex Pre-eclampsia Families Identifies SORD, DGKI, and ICA1 as Novel Candidate Risk Genes.Front Genet. 2019 Mar 19;10:227. doi: 10.3389/fgene.2019.00227. eCollection 2019.
15	Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.Mol Hum Reprod. 2013 Oct;19(10):697-708. doi: 10.1093/molehr/gat044. Epub 2013 Jun 13.
16	High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.J Immunol. 2018 Nov 1;201(9):2593-2601. doi: 10.4049/jimmunol.1800860. Epub 2018 Sep 24.
17	Expression of placenta growth factor, soluble fms-like tyrosine kinase-1, metal-responsive transcription factor-1, heme oxygenase 1 and hypoxia inducible factor-1 mRNAs in pre-eclampsia placenta and the effect of pre-eclampsia sera on their expression of choriocarcinoma cells.J Obstet Gynaecol Res. 2014 Oct;40(10):2095-103. doi: 10.1111/jog.12462. Epub 2014 Aug 11.
18	Potential role for nectin-4 in the pathogenesis of pre-eclampsia: a molecular genetic study.BMC Med Genet. 2018 Sep 14;19(1):166. doi: 10.1186/s12881-018-0681-y.
19	Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion.Clin Exp Pharmacol Physiol. 2020 Jan;47(1):49-59. doi: 10.1111/1440-1681.13169. Epub 2019 Oct 7.
20	Plasma mRNA concentrations of placenta-specific 1 (PLAC1) and pregnancy associated plasma protein A (PAPP-A) are higher in early-onset than late-onset pre-eclampsia.J Obstet Gynaecol Res. 2011 Apr;37(4):313-8. doi: 10.1111/j.1447-0756.2010.01349.x. Epub 2011 Mar 9.
21	Increased fetal RhD gene in the maternal circulation in early pregnancy is associated with an increased risk of pre-eclampsia.BJOG. 2005 May;112(5):584-7. doi: 10.1111/j.1471-0528.2004.00499.x.
22	Pre-eclampsia: the Potential of GSNO Reductase Inhibitors.Curr Hypertens Rep. 2017 Mar;19(3):20. doi: 10.1007/s11906-017-0717-2.
23	Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes.Diabetologia. 2017 Dec;60(12):2514-2524. doi: 10.1007/s00125-017-4415-z. Epub 2017 Sep 5.
24	PCSK6-mediated corin activation is essential for normal blood pressure.Nat Med. 2015 Sep;21(9):1048-53. doi: 10.1038/nm.3920. Epub 2015 Aug 10.
25	Neurokinin B and pre-eclampsia: a decade of discovery.Reprod Biol Endocrinol. 2010 Jan 14;8:4. doi: 10.1186/1477-7827-8-4.
26	Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia.Behav Brain Res. 2019 May 17;364:403-412. doi: 10.1016/j.bbr.2017.12.031. Epub 2017 Dec 27.
27	Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies.Placenta. 2012 Sep;33(9):741-4. doi: 10.1016/j.placenta.2012.06.011. Epub 2012 Jul 11.
28	Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia.Biochim Biophys Acta. 2003 May 20;1638(1):63-71. doi: 10.1016/s0925-4439(03)00043-7.
29	Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia.Placenta. 2004 May;25(5):413-21. doi: 10.1016/j.placenta.2003.10.014.
30	Pregnancy-associated plasma protein A gene polymorphism in pregnant women with preeclampsia and intrauterine growth restriction.Kaohsiung J Med Sci. 2015 Oct;31(10):518-22. doi: 10.1016/j.kjms.2015.08.005. Epub 2015 Sep 28.
31	Characterization of Human Pregnancy Specific Glycoprotein (PSG) Gene Copy Number Variations in Pre-eclampsia Patients.Adv Exp Med Biol. 2016;924:63-65. doi: 10.1007/978-3-319-42044-8_12.
32	Hypoxia-induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP-2: implications for placental development during pre-eclampsia.J Cell Biochem. 2013 Jan;114(1):89-98. doi: 10.1002/jcb.24304.
33	The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.Hum Mol Genet. 2010 Jul 1;19(13):2658-67. doi: 10.1093/hmg/ddq152. Epub 2010 Apr 16.
34	The human tumor-associated antigen RCAS1 in pregnancies complicated by pre-eclampsia.J Reprod Immunol. 2008 Jan;77(1):100-8. doi: 10.1016/j.jri.2007.05.001. Epub 2007 Jul 2.
35	Int6/eIF3e Silencing Promotes Placenta Angiogenesis in a Rat Model of Pre-eclampsia.Sci Rep. 2018 Jun 12;8(1):8944. doi: 10.1038/s41598-018-27296-2.
36	ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.Hum Mol Genet. 2010 Jun 15;19(12):2456-67. doi: 10.1093/hmg/ddq128. Epub 2010 Mar 30.
37	Identification of potential crucial genes associated with early-onset pre-eclampsia via a microarray analysis.J Obstet Gynaecol Res. 2017 May;43(5):812-819. doi: 10.1111/jog.13275.
38	Early-life determinants of hypoxia-inducible factor 3A gene(HIF3A) methylation: a birth cohort study.Clin Epigenetics. 2019 Jul 1;11(1):96. doi: 10.1186/s13148-019-0687-0.
39	Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.Placenta. 2012 Nov;33(11):919-26. doi: 10.1016/j.placenta.2012.08.003. Epub 2012 Sep 8.
40	Contribution of interferon-gamma receptor 1 gene polymorphisms to pre-eclampsia in China.Am J Reprod Immunol. 2010 Apr 1;63(4):331-8. doi: 10.1111/j.1600-0897.2009.00801.x. Epub 2010 Jan 12.
41	miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2.Cell Death Dis. 2018 Jan 16;9(2):16. doi: 10.1038/s41419-017-0045-0.
42	Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.Hum Mol Genet. 2015 Jan 1;24(1):118-27. doi: 10.1093/hmg/ddu423. Epub 2014 Aug 20.
43	The possible role of CD8+/V7.2+/CD161++ T (MAIT) and CD8+/V7.2+/CD161(lo) T (MAIT-like) cells in the pathogenesis of early-onset pre-eclampsia.Am J Reprod Immunol. 2018 Feb;79(2). doi: 10.1111/aji.12805. Epub 2017 Dec 19.
44	Influence of NKG2C gene deletion and CCR532 in Pre-eclampsia-Approaching the effect of innate immune gene variants in pregnancy.Int J Immunogenet. 2019 Apr;46(2):82-87. doi: 10.1111/iji.12416. Epub 2019 Feb 20.
45	The effects of sildenafil citrate on urinary podocin and nephrin mRNA expression in an L-NAME model of pre-eclampsia.Mol Cell Biochem. 2017 Mar;427(1-2):59-67. doi: 10.1007/s11010-016-2897-5. Epub 2016 Dec 19.
46	PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia.Reprod Fertil Dev. 2014 Jan;26(2):351-7. doi: 10.1071/RD12384.
47	Prokineticin 1 is up-regulated by insulin in decidualizing human endometrial stromal cells.J Cell Mol Med. 2018 Jan;22(1):163-172. doi: 10.1111/jcmm.13305. Epub 2017 Aug 7.
48	SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.PLoS One. 2017 May 17;12(5):e0178056. doi: 10.1371/journal.pone.0178056. eCollection 2017.