General Information of Drug Off-Target (DOT) (ID: OTELM5C2)

DOT Name Secernin-1 (SCRN1)
Gene Name SCRN1
Related Disease
ABeta amyloidosis, dutch type ( )
Advanced cancer ( )
Colon cancer ( )
Colon carcinoma ( )
Corticobasal degeneration ( )
Lung neoplasm ( )
Oculocerebrorenal syndrome ( )
Pick disease ( )
Progressive supranuclear palsy ( )
Stomach cancer ( )
Tauopathy ( )
Alzheimer disease ( )
Colorectal carcinoma ( )
Gastric cancer ( )
Gastric neoplasm ( )
Hereditary diffuse gastric adenocarcinoma ( )
Keratoconjunctivitis sicca ( )
Neoplasm ( )
Osteoarthritis ( )
Psoriasis ( )
UniProt ID
SCRN1_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF03577
Sequence
MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISID
QVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERG
ETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKV
TEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKD
SLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDP
SRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIES
DQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK
Function Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium.

Molecular Interaction Atlas (MIA) of This DOT

20 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
ABeta amyloidosis, dutch type DIS6LNS5 Strong Biomarker [1]
Advanced cancer DISAT1Z9 Strong Biomarker [2]
Colon cancer DISVC52G Strong Altered Expression [2]
Colon carcinoma DISJYKUO Strong Altered Expression [2]
Corticobasal degeneration DISSMOTT Strong Biomarker [1]
Lung neoplasm DISVARNB Strong Altered Expression [3]
Oculocerebrorenal syndrome DIS8TEDY Strong Biomarker [4]
Pick disease DISP6X50 Strong Biomarker [1]
Progressive supranuclear palsy DISO5KRQ Strong Biomarker [1]
Stomach cancer DISKIJSX Strong Genetic Variation [5]
Tauopathy DISY2IPA Strong Biomarker [1]
Alzheimer disease DISF8S70 moderate Biomarker [1]
Colorectal carcinoma DIS5PYL0 Limited Altered Expression [6]
Gastric cancer DISXGOUK Limited Genetic Variation [5]
Gastric neoplasm DISOKN4Y Limited Biomarker [7]
Hereditary diffuse gastric adenocarcinoma DISUIBYS Limited Biomarker [7]
Keratoconjunctivitis sicca DISNOENH Limited Biomarker [8]
Neoplasm DISZKGEW Limited Altered Expression [2]
Osteoarthritis DIS05URM Limited Biomarker [9]
Psoriasis DIS59VMN Limited Genetic Variation [10]
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⏷ Show the Full List of 20 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Topotecan DMP6G8T Approved Secernin-1 (SCRN1) affects the response to substance of Topotecan. [26]
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14 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of Secernin-1 (SCRN1). [11]
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Secernin-1 (SCRN1). [12]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Secernin-1 (SCRN1). [13]
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Secernin-1 (SCRN1). [14]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Secernin-1 (SCRN1). [15]
Cisplatin DMRHGI9 Approved Cisplatin affects the expression of Secernin-1 (SCRN1). [16]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Secernin-1 (SCRN1). [17]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of Secernin-1 (SCRN1). [18]
Vorinostat DMWMPD4 Approved Vorinostat decreases the expression of Secernin-1 (SCRN1). [19]
Decitabine DMQL8XJ Approved Decitabine increases the expression of Secernin-1 (SCRN1). [7]
Phenobarbital DMXZOCG Approved Phenobarbital affects the expression of Secernin-1 (SCRN1). [21]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Secernin-1 (SCRN1). [22]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Secernin-1 (SCRN1). [24]
Deguelin DMXT7WG Investigative Deguelin decreases the expression of Secernin-1 (SCRN1). [25]
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⏷ Show the Full List of 14 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Secernin-1 (SCRN1). [23]
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References

1 Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies.Acta Neuropathol Commun. 2019 Dec 3;7(1):195. doi: 10.1186/s40478-019-0848-6.
2 Secernin-1 contributes to colon cancer progression through enhancing matrix metalloproteinase-2/9 exocytosis.Dis Markers. 2015;2015:230703. doi: 10.1155/2015/230703. Epub 2015 Feb 26.
3 Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.Oncotarget. 2016 Mar 22;7(12):13797-809. doi: 10.18632/oncotarget.7318.
4 Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3511-6. doi: 10.1073/pnas.0914658107. Epub 2010 Feb 2.
5 A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.Sci Rep. 2014 Nov 17;4:7080. doi: 10.1038/srep07080.
6 SCRN1 is a novel marker for prognosis in colorectal cancer.J Surg Oncol. 2010 Feb 1;101(2):156-9. doi: 10.1002/jso.21459.
7 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
8 Incidence and Risk Factors of Dry Eye in a Spanish Adult Population: 11-Year Follow-Up From the Salns Eye Study.Cornea. 2018 Dec;37(12):1527-1534. doi: 10.1097/ICO.0000000000001713.
9 Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.Mol Cell Proteomics. 2009 Jan;8(1):172-89. doi: 10.1074/mcp.M800292-MCP200. Epub 2008 Sep 9.
10 Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.Nat Commun. 2015 Apr 9;6:6793. doi: 10.1038/ncomms7793.
11 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
12 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
13 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
14 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
15 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
16 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
17 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
18 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
19 Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24. doi: 10.4161/auto.6.6.12397. Epub 2010 Aug 17.
20 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
21 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
22 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
23 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
24 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
25 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
26 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.