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Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Transl Psychiatry. 2017 Feb 14;7(2):e1028. doi: 10.1038/tp.2016.291.
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| 2 |
Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci. 2007 Mar;96(1):21-9.
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| 3 |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
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A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.Nat Genet. 2007 May;39(5):605-13. doi: 10.1038/ng2030. Epub 2007 Apr 22.
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Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
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Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.Nat Genet. 2014 Jun;46(6):583-7. doi: 10.1038/ng.2984. Epub 2014 May 11.
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Germline mutations in MAP3K6 are associated with familial gastric cancer. PLoS Genet. 2014 Oct 23;10(10):e1004669. doi: 10.1371/journal.pgen.1004669. eCollection 2014 Oct.
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Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer.Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12492-7. doi: 10.1073/pnas.1507491112. Epub 2015 Sep 23.
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A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.PLoS One. 2011 Feb 18;6(2):e16694. doi: 10.1371/journal.pone.0016694.
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Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China.Int J Cancer. 2006 Dec 1;119(11):2592-6. doi: 10.1002/ijc.22206.
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MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.Oncotarget. 2016 Jul 12;7(28):43492-43503. doi: 10.18632/oncotarget.9523.
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Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PLoS One. 2013;8(1):e54774. doi: 10.1371/journal.pone.0054774. Epub 2013 Jan 30.
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Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread.Cancer Biol Ther. 2007 Aug;6(8):1218-26. doi: 10.4161/cbt.6.8.4412. Epub 2007 Aug 10.
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A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9990-5. doi: 10.1073/pnas.152706299. Epub 2002 Jul 9.
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Two-dimensional differential in-gel electrophoresis for identification of gastric cancer-specific protein markers.Oncol Rep. 2009 Jun;21(6):1429-37. doi: 10.3892/or_00000371.
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Loss-of-function variants in ATM confer risk of gastric cancer.Nat Genet. 2015 Aug;47(8):906-10. doi: 10.1038/ng.3342. Epub 2015 Jun 22.
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Rebamipide inhibits gastric cancer growth by targeting survivin and Aurora-B. Biochem Biophys Res Commun. 2005 Aug 19;334(1):207-12. doi: 10.1016/j.bbrc.2005.05.204.
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Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.Cancer Res. 2016 Jan 15;76(2):206-15. doi: 10.1158/0008-5472.CAN-15-0295. Epub 2015 Dec 30.
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Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene. 2004 Jan 15;23(2):503-13. doi: 10.1038/sj.onc.1207173.
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| 20 |
Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.Oncogene. 2006 Apr 27;25(18):2666-73. doi: 10.1038/sj.onc.1209297.
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Diverse proteomic alterations in gastric adenocarcinoma.Proteomics. 2004 Oct;4(10):3276-87. doi: 10.1002/pmic.200300916.
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Cyclin D1/cdk4, estrogen receptors and , in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study.J Toxicol Sci. 2011 Jun;36(3):373-8. doi: 10.2131/jts.36.373.
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CD44-SLC1A2 gene fusions in gastric cancer. Sci Transl Med. 2011 Apr 6;3(77):77ra30. doi: 10.1126/scitranslmed.3001423.
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P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori.Gut. 2004 Jun;53(6):797-804. doi: 10.1136/gut.2003.032144.
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CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.Br J Cancer. 2011 Mar 29;104(7):1126-34. doi: 10.1038/bjc.2011.24. Epub 2011 Mar 1.
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Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.BMC Cancer. 2008 Jul 25;8:210. doi: 10.1186/1471-2407-8-210.
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| 27 |
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.J Clin Oncol. 2011 Dec 20;29(36):4803-10. doi: 10.1200/JCO.2011.35.4928. Epub 2011 Oct 31.
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Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.Pharmacogenomics J. 2012 Apr;12(2):119-27. doi: 10.1038/tpj.2010.87. Epub 2010 Dec 21.
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Regression of upper gastric cancer in mice by FHIT gene delivery.FASEB J. 2003 Sep;17(12):1768-70. doi: 10.1096/fj.03-0241fje. Epub 2003 Jul 3.
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Implication of peroxisome proliferator-activated receptor gamma and proinflammatory cytokines in gastric carcinogenesis: link to Helicobacter pylori-infection. J Pharmacol Sci. 2004 Oct;96(2):134-43. doi: 10.1254/jphs.fpj04016x. Epub 2004 Oct 9.
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Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. Cancer Chemother Pharmacol. 2005 Apr;55(4):393-403. doi: 10.1007/s00280-004-0904-0. Epub 2004 Oct 5.
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Expression and function of heme oxygenase-1 in human gastric cancer.Exp Biol Med (Maywood). 2012 Apr;237(4):362-71. doi: 10.1258/ebm.2011.011193. Epub 2012 Apr 4.
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Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression. PLoS One. 2012;7(2):e31207. doi: 10.1371/journal.pone.0031207. Epub 2012 Feb 20.
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HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer.Histopathology. 2011 Apr;58(5):669-78. doi: 10.1111/j.1365-2559.2011.03818.x. Epub 2011 Mar 30.
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Expression of acidosis-dependent genes in human cancer nests.Mol Clin Oncol. 2014 Nov;2(6):1160-1166. doi: 10.3892/mco.2014.344. Epub 2014 Jul 11.
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Quantitative expression of the homeobox and integrin genes in human gastric carcinoma.Int J Mol Med. 2007 Oct;20(4):621-9.
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Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer. Cancer Sci. 2007 May;98(5):707-15. doi: 10.1111/j.1349-7006.2007.00435.x. Epub 2007 Mar 9.
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Catenin family genes are not commonly mutated in hereditary diffuse gastric cancer.Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2272-4. doi: 10.1158/1055-9965.EPI-12-1110. Epub 2012 Oct 15.
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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.Nat Genet. 2012 May;44(5):570-4. doi: 10.1038/ng.2246.
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Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.Chem Biol Interact. 2001 Jun 1;135-136:373-86. doi: 10.1016/s0009-2797(01)00179-x.
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Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of -catenin in gastric cancer. Clin Exp Metastasis. 2011 Dec;28(8):743-50. doi: 10.1007/s10585-011-9406-8. Epub 2011 Jul 13.
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c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.Cancer Res. 2008 Jul 1;68(13):5031-9. doi: 10.1158/0008-5472.CAN-07-6332.
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Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
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Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. J Nutr Biochem. 2012 Nov;23(11):1434-9. doi: 10.1016/j.jnutbio.2011.09.004. Epub 2012 Jan 27.
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Association of MMP7 -181AG Promoter Polymorphism with Gastric Cancer Risk: INFLUENCE OF NICOTINE IN DIFFERENTIAL ALLELE-SPECIFIC TRANSCRIPTION VIA INCREASED PHOSPHORYLATION OF cAMP-RESPONSE ELEMENT-BINDING PROTEIN (CREB).J Biol Chem. 2015 Jun 5;290(23):14391-406. doi: 10.1074/jbc.M114.630129. Epub 2015 Apr 6.
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Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer.Br J Cancer. 2012 Jun 26;107(1):137-42. doi: 10.1038/bjc.2012.235. Epub 2012 May 29.
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DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy.Ann Surg Oncol. 2011 Sep;18(9):2688-98. doi: 10.1245/s10434-011-1601-y. Epub 2011 Feb 24.
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Expression of hsa-miR-9 and MYC Copy Number Variation in Hereditary Diffuse Gastric Cancer.Anticancer Res. 2017 May;37(5):2401-2406. doi: 10.21873/anticanres.11579.
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Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.Med Sci Monit. 2019 Jan 23;25:656-665. doi: 10.12659/MSM.912813.
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Decrease in nucleophosmin/B23 mRNA and telomerase activity during indomethacin-induced apoptosis of gastric KATO-III cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):683-90. doi: 10.1007/s002109900145.
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Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines.Cancer Biol Ther. 2007 May;6(5):769-74. doi: 10.4161/cbt.6.5.4001. Epub 2007 Feb 12.
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DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.Cancer. 2005 Oct 15;104(8):1609-19. doi: 10.1002/cncr.21392.
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Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007 Jun 28;26(30):4383-93. doi: 10.1038/sj.onc.1210215. Epub 2007 Jan 22.
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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.Nat Genet. 2014 Jun;46(6):573-82. doi: 10.1038/ng.2983. Epub 2014 May 11.
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Metastasis-induction and apoptosis-protection by TWIST in gastric cancer cells. Clin Exp Metastasis. 2009;26(8):1013-23. doi: 10.1007/s10585-009-9291-6. Epub 2009 Oct 6.
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Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker.BMC Cancer. 2008 May 27;8:148. doi: 10.1186/1471-2407-8-148.
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Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer Lett. 2010 Jun 28;292(2):237-45.
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Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
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DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.Eur J Cancer. 2011 Aug;47(12):1817-25. doi: 10.1016/j.ejca.2011.02.024. Epub 2011 Mar 31.
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Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients. Mol Cells. 2003 Aug 31;16(1):13-8.
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Alternative pre-mRNA splicing in digestive tract malignancy.Cancer Sci. 2011 Feb;102(2):309-16. doi: 10.1111/j.1349-7006.2010.01797.x. Epub 2010 Dec 7.
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Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer.Clin Chim Acta. 2009 Aug;406(1-2):45-51. doi: 10.1016/j.cca.2009.05.008. Epub 2009 May 19.
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Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.Mol Cancer Res. 2008 Feb;6(2):222-30. doi: 10.1158/1541-7786.MCR-07-0142.
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Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer.J Pathol. 2005 Oct;207(2):199-206. doi: 10.1002/path.1821.
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MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region.Food Chem Toxicol. 2019 Nov;133:110779. doi: 10.1016/j.fct.2019.110779. Epub 2019 Aug 28.
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Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer.Clin Cancer Res. 2012 May 15;18(10):2987-96. doi: 10.1158/1078-0432.CCR-11-2863. Epub 2012 Mar 27.
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Inactivating mutation of the pro-apoptotic gene BID in gastric cancer. J Pathol. 2004 Apr;202(4):439-45. doi: 10.1002/path.1532.
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DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.Hum Mol Genet. 2014 Apr 15;23(8):2094-105. doi: 10.1093/hmg/ddt602. Epub 2013 Nov 29.
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The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18.Hum Genet. 1992 May;89(3):347-50. doi: 10.1007/BF00220557.
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Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy.Biomarkers. 2011 Feb;16(1):74-82. doi: 10.3109/1354750X.2010.533284. Epub 2010 Dec 6.
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Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy.World J Gastroenterol. 2006 Oct 7;12(37):6032-6. doi: 10.3748/wjg.v12.i37.6032.
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Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer. PLoS One. 2011;6(10):e25564. doi: 10.1371/journal.pone.0025564. Epub 2011 Oct 19.
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Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer.J Clin Pathol. 2008 Jan;61(1):25-30. doi: 10.1136/jcp.2006.043679. Epub 2007 May 18.
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Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients.Clin Cancer Res. 2005 Apr 15;11(8):3025-31. doi: 10.1158/1078-0432.CCR-04-1605.
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Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer.Cancer Lett. 2007 Jun 18;251(1):78-85. doi: 10.1016/j.canlet.2006.11.006. Epub 2006 Dec 19.
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LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.Cancer Res. 2008 Sep 1;68(17):7147-55. doi: 10.1158/0008-5472.CAN-08-0667.
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Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study.Lancet Gastroenterol Hepatol. 2018 Jul;3(7):489-498. doi: 10.1016/S2468-1253(18)30079-7. Epub 2018 Apr 27.
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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.Nat Genet. 2010 Sep;42(9):764-7. doi: 10.1038/ng.649. Epub 2010 Aug 22.
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Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer. World J Gastroenterol. 2007 Nov 21;13(43):5692-8. doi: 10.3748/wjg.v13.i43.5692.
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Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.Gastroenterology. 2005 Jun;128(7):1965-83. doi: 10.1053/j.gastro.2005.03.027.
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Genetic variations in the SMAD4 gene and gastric cancer susceptibility.World J Gastroenterol. 2010 Nov 28;16(44):5635-41. doi: 10.3748/wjg.v16.i44.5635.
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Spasmolytic polypeptide-expressing metaplasia associated with higher expressions of miR-21, 155, and 223 can be regressed by Helicobacter pylori eradication in the gastric cancer familial relatives.Helicobacter. 2019 Jun;24(3):e12578. doi: 10.1111/hel.12578. Epub 2019 Apr 16.
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